Paul Saladino

In the human body, LDL is valuable. LDL serves an immune role. We've often been told LDL cholesterol is just there to kill us, which makes no sense evolutionarily. Sometimes you hear this explanation that like, we don't need LDL anymore because now we have antibiotics. But I think that's a little bit, that doesn't really jive with me. Historically,

In the human body, LDL is valuable. LDL serves an immune role. We've often been told LDL cholesterol is just there to kill us, which makes no sense evolutionarily. Sometimes you hear this explanation that like, we don't need LDL anymore because now we have antibiotics. But I think that's a little bit, that doesn't really jive with me. Historically,

All throughout our time as humans, LDL is an immune particle. It interrupts infections in our body, whether viral or bacterial. Bacteria and viruses communicate with each other using something called quorum sensing, and LDL particles and other lipoproteins can interrupt that. So LDL has value in the human body.

All throughout our time as humans, LDL is an immune particle. It interrupts infections in our body, whether viral or bacterial. Bacteria and viruses communicate with each other using something called quorum sensing, and LDL particles and other lipoproteins can interrupt that. So LDL has value in the human body.

All throughout our time as humans, LDL is an immune particle. It interrupts infections in our body, whether viral or bacterial. Bacteria and viruses communicate with each other using something called quorum sensing, and LDL particles and other lipoproteins can interrupt that. So LDL has value in the human body.

And it's probably not surprising then that if we look at some of the longest-lived people, they often have elevated levels of LDL. because they're not insulin resistant. So my assertion, and this is very controversial and I'm happy to defend at any time in the right forum, is that if you are insulin sensitive, if you are metabolically healthy, LDL is good for you.

And it's probably not surprising then that if we look at some of the longest-lived people, they often have elevated levels of LDL. because they're not insulin resistant. So my assertion, and this is very controversial and I'm happy to defend at any time in the right forum, is that if you are insulin sensitive, if you are metabolically healthy, LDL is good for you.

And it's probably not surprising then that if we look at some of the longest-lived people, they often have elevated levels of LDL. because they're not insulin resistant. So my assertion, and this is very controversial and I'm happy to defend at any time in the right forum, is that if you are insulin sensitive, if you are metabolically healthy, LDL is good for you.

It's an immune particle, it's valuable. It's when you become insulin resistant that it becomes a liability because it's part of the causal cascade. What is a problem if you live in a place with a lot of lightning storms and you have a bunch of dry wood around? If you don't have lightning storms, wood is great, right? You want to build things. I can build a canoe. I can build a fishing rod.

It's an immune particle, it's valuable. It's when you become insulin resistant that it becomes a liability because it's part of the causal cascade. What is a problem if you live in a place with a lot of lightning storms and you have a bunch of dry wood around? If you don't have lightning storms, wood is great, right? You want to build things. I can build a canoe. I can build a fishing rod.

It's an immune particle, it's valuable. It's when you become insulin resistant that it becomes a liability because it's part of the causal cascade. What is a problem if you live in a place with a lot of lightning storms and you have a bunch of dry wood around? If you don't have lightning storms, wood is great, right? You want to build things. I can build a canoe. I can build a fishing rod.

I can build a house. You don't want to get rid of all your wood. And we know that when you lower LDL, there are potential problems in humans. Now, The data around lowering LDL becomes muddy because drugs that lower LDL can have side effects.

I can build a house. You don't want to get rid of all your wood. And we know that when you lower LDL, there are potential problems in humans. Now, The data around lowering LDL becomes muddy because drugs that lower LDL can have side effects.

I can build a house. You don't want to get rid of all your wood. And we know that when you lower LDL, there are potential problems in humans. Now, The data around lowering LDL becomes muddy because drugs that lower LDL can have side effects.

But for instance, statin drugs, which lower LDL by interrupting their synthesis in this cascade of cholesterol synthesis, they're HMG-CoA reductase inhibitors. They inhibit an enzyme in this cholesterol synthesis pathway. They're associated with slightly increased rates of diabetes, dementia, myalgias, lower libido.

But for instance, statin drugs, which lower LDL by interrupting their synthesis in this cascade of cholesterol synthesis, they're HMG-CoA reductase inhibitors. They inhibit an enzyme in this cholesterol synthesis pathway. They're associated with slightly increased rates of diabetes, dementia, myalgias, lower libido.

But for instance, statin drugs, which lower LDL by interrupting their synthesis in this cascade of cholesterol synthesis, they're HMG-CoA reductase inhibitors. They inhibit an enzyme in this cholesterol synthesis pathway. They're associated with slightly increased rates of diabetes, dementia, myalgias, lower libido.

lowering LDL, lowering cholesterol production is not always, it's not without problems. And to think that historically or by design or evolutionarily, that LDL is just there to kill us, that doesn't make any sense. And that eating a food that is at the center of the human diet for all of human history, like red meat that has saturated fat,

lowering LDL, lowering cholesterol production is not always, it's not without problems. And to think that historically or by design or evolutionarily, that LDL is just there to kill us, that doesn't make any sense. And that eating a food that is at the center of the human diet for all of human history, like red meat that has saturated fat,

lowering LDL, lowering cholesterol production is not always, it's not without problems. And to think that historically or by design or evolutionarily, that LDL is just there to kill us, that doesn't make any sense. And that eating a food that is at the center of the human diet for all of human history, like red meat that has saturated fat,