Paul Turek

It's a chromosome 7. There's 1,700, 1,800 mutations, maybe 2,000. So they cloned the genes and got the variants in the late 80s. And then they found that there's another group of men who are perfectly healthy, do not have cystic fibrosis, which is a major metabolic disease with a short life expectancy, better now. Those men had absent vas deferens in the absence of disease.

It's a chromosome 7. There's 1,700, 1,800 mutations, maybe 2,000. So they cloned the genes and got the variants in the late 80s. And then they found that there's another group of men who are perfectly healthy, do not have cystic fibrosis, which is a major metabolic disease with a short life expectancy, better now. Those men had absent vas deferens in the absence of disease.

They took the gene sets and looked at them, and they were the same, just not as many. So you have homozygous or heterozygous. So you have a carrier for cystic fibrosis will have an absent vas, but a full-blown CF patient, cystic fibrosis patient, will have no vas deferens too. So it's a form fruit of cystic fibrosis, but it doesn't have all the chemical and metabolic side effects.

They took the gene sets and looked at them, and they were the same, just not as many. So you have homozygous or heterozygous. So you have a carrier for cystic fibrosis will have an absent vas, but a full-blown CF patient, cystic fibrosis patient, will have no vas deferens too. So it's a form fruit of cystic fibrosis, but it doesn't have all the chemical and metabolic side effects.

Yeah. And then you have to worry if there's a 4% chance in America anyway that a partner might carry it. There are two carriers. You have a one in four chance of having a very affected child. So that's the big concern in my practice. And I'm proud to say in 30 years, we have no CF children. It's all about good engineering and doing it right. So that's the vast difference part.

Yeah. And then you have to worry if there's a 4% chance in America anyway that a partner might carry it. There are two carriers. You have a one in four chance of having a very affected child. So that's the big concern in my practice. And I'm proud to say in 30 years, we have no CF children. It's all about good engineering and doing it right. So that's the vast difference part.

What else on physical exam are you looking for?

What else on physical exam are you looking for?

Yeah. So among viruses in the world, There aren't many that get into the testicle like other things. Very little gets into the testicle, similar to the brain. But the mumps virus does it about a third of the time when you're a child with mumps, the parotid gland infection. It's a glandular disease. So it really only matters when you're pubertal and you get mumps. Then it goes to lots of glands.

Yeah. So among viruses in the world, There aren't many that get into the testicle like other things. Very little gets into the testicle, similar to the brain. But the mumps virus does it about a third of the time when you're a child with mumps, the parotid gland infection. It's a glandular disease. So it really only matters when you're pubertal and you get mumps. Then it goes to lots of glands.

It goes to your pancreas, cause diabetes. It can go to the salivary glands. It can go to the testicles.

It goes to your pancreas, cause diabetes. It can go to the salivary glands. It can go to the testicles.

And it will cause viral necrosis and edema of the testis. And similar to a brain, it's in a calvarium, right? The brain is in a fixed space. So when it swells, you got to do something because it can die if it swells too much. Testicle is a fixed cavity with the tunica albiginea. And so if it swells too much, it necrosis, and then you get fibrosis, and then you get sterility.

And it will cause viral necrosis and edema of the testis. And similar to a brain, it's in a calvarium, right? The brain is in a fixed space. So when it swells, you got to do something because it can die if it swells too much. Testicle is a fixed cavity with the tunica albiginea. And so if it swells too much, it necrosis, and then you get fibrosis, and then you get sterility.

I've got techniques where I can find sperm in lots of these men, little pockets, but most of it, you're ablating the testis. It's going to scar and die from ischemic necrosis. Zika, Ebola. I mean, the CDC called me when these were coming around. Zika has been transmitted through semen. It causes the anencephaly issues. When these pandemics were occurring, Ebola too.

I've got techniques where I can find sperm in lots of these men, little pockets, but most of it, you're ablating the testis. It's going to scar and die from ischemic necrosis. Zika, Ebola. I mean, the CDC called me when these were coming around. Zika has been transmitted through semen. It causes the anencephaly issues. When these pandemics were occurring, Ebola too.

I got a call that there was an Ebola patient who survived, went to the institute, survived hemorrhagic fever. And then a year later, transmitted Ebola to a partner who transmitted to six other men. And it was another outbreak in South Africa.

I got a call that there was an Ebola patient who survived, went to the institute, survived hemorrhagic fever. And then a year later, transmitted Ebola to a partner who transmitted to six other men. And it was another outbreak in South Africa.

Right. We don't know about testes, but we know that mumps will do that to the testes, but Zika is also persistent in the semen.

Right. We don't know about testes, but we know that mumps will do that to the testes, but Zika is also persistent in the semen.