Paul Turek
speaker
358 appearances
1 recordings
1 series
first heard Jun 2025
last heard Jun 2025
Paul Turek’s voice in public audio — every appearance, attributed to the second.
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That got me a little angry. So I did a study with USC and I took these men that I cleared and I called them up a year later. And I said, what happened last year after Turek cleared you? How did a resident do this? And the answer was 65% had conceived naturally. Another 15 to 20% conceived with IUI or IVF. These women were 35 years old, year and a half infertility.
They weren't going to wait around. Most conceptions occurred within six months. I didn't do anything for them. I didn't fix their varicoceles. I didn't touch them any medication. I just said, you're fine. So I published it as a lifestyle study. Not that I was right. And the idea was they probably made changes. They probably took a nutritional supplement. They probably timed their sex better.
They probably got out of hot tubs and all that stuff. And they were taking pills. I have a list of what they did. I had a table in that paper that said that 65% natural pregnancy rate, that is higher than anything I can offer as a treatment that we have published on. So if you fix their varicose seal, you rarely get a 65% natural conception rate.
So I had a table of all the published conception rates for the technologies that work, and I'm saying this is even better. So if that addresses your question, that's the only data I have.
paternal age and fertility, paternal age. So we can go there, but I don't place value judgments. I say, good idea. A disclosure, I'm on a board of legacy. I love their mission driven. I like the fact they're going for military and exposed patients and this and that and VA. I'm for that. I think it's the lowest hanging fruit in the field, obviously for cancer survivors and things.
I don't care what you think might happen with your cancer. I would still bank it. I started a nonprofit called Banking on the Future. 16 year olds to 21 year olds with cancer. We'll do it for you. We'll pay for it for five years. Just give us a sample because it's so much harder afterwards or not.
Now, should anyone do it for any reason? Probably not. But again, I don't pass the judgment. If they're worried about something, then they should. What paternal age do you worry about? And you look at national guidelines for sperm donation, 40 is considered older paternal age, 50 for sure.
If you look at risks to offspring, miscarriages, stillborns, autism, birth defects, things immediately related to conception, prematurity, Those go up with paternal age. Then you look at birth defects. When they're born, those go up one to twofold. And then the worrisome ones are the single gene defects and the epigenetics like psychiatric morbidity.
So the autism, schizophrenia, dyslexia, bipolar disorder, potentially Alzheimer's in offspring. And they're not detectable young. So big issues. I've written a lot about that, published on it. I was actually having my second child at 50 when I was writing this thing. Should I be doing this? Writing a paper on all these risks and with Alan Dechenko from University of Pittsburgh.
But I think it's a hockey stick curve for risk to offspring. And you think the inflection is 40 or 50? I think it's more like 60. I think there's a slow linear increase in risk to offspring from 25 to 50 or 60. And then there's an inflection and then there's the blade of the stick. And I think that's logarithmic. Same curve as women with chromosomal.
Yeah, so it's a shorter curve, but the same thing, 40, 38 to 40 is kind of a point where things really ramp up with chromosomes. The men's stuff is not chromosomal. If you take the curves together, they're different spans, same shape, but I think the female curve is on top of the male curve. This is not the same relative risk.
So women, you go from 25 to 40, your chance of a miscarriage, though it's chromosomal, it goes up quite significantly after that. Very significantly. And the consequence of women's issues with offspring related health is basically miscarriage.
And now prevented with pre-imputation genetic testing. Men are different. You can't detect these things. They're single gene mutations. The machinery is constantly working. It's getting old. The quality control of the process goes down and little gene mutations get in there that are always being spun off in the heat of the engine. They're not getting vetted.
So the machinery is not doing a good job. So they're getting through and they're not going to be lethal. They're going to be deleterious. So that's where you get things. And autism is a classic one, paternal age related. Looks like that's the biggest risk factor for it. And that worries me a lot.
So the facts are that human evolution is entirely driven by sperm because eggs are just sitting there correcting the problem. It's entirely driven by sperm. And so 50 mutations a year, a generation usually gets spit out based on a nature paper. probably between generations. And there's always mutations occurring in 14-year-old fathers, but it goes way up with 60-year-old fathers.
So the rate of mutations goes way up with age, but it averages 50 over a reproductive life. And most of them, half of the mutations that we are throwing off as a species are are not ears or hands or feet or height. It's all neurodevelopmental. It's like half neurodevelopmental.
So when you think about what we're seeing, you know, the Martians from the fifties and the movies with big heads, that's kind of where we're headed. It's autism, dyslexia, bipolar disorder. These are neurodevelopmental neurodegenerative issues. And why is that? Well, that's what's going on. I mean, that's where we're being stimulated. That's where we're being asked to evolve.
Look at the last 30 years. Funny. One of the biggest investors in Salesforce said to me, I realized I was dyslexic when my son was born. And I said, really? He said, yeah, but you know what? It helped me be the man I am to realize that Salesforce is going to fly. Gave him the first 500,000, gave him the first million, never took any more money. And he said, it let me focus.
So autism is one of those diseases where you put out, you ignore a lot of input and And you find the gift and it's amazing. If you go down the rabbit hole of what they're good at, it's like their whole brain trust is there. So is that a disease or is that where we're headed?
Maybe it's where we're headed. Maybe it's the future. Maybe the non-sequiturs that come out of those brains. Look at who's changing the world right now, at least in Silicon Valley.
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