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Paul Turek

👤 Person
716 total appearances

Appearances Over Time

Podcast Appearances

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

They're in the normal range more. What gives you side effects from testosterone, including sterility,

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

They're in the normal range more. What gives you side effects from testosterone, including sterility,

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

Testosterone, I can wait. And it was not available in America for 50 years. It was available in Europe. And a couple of researchers at UCLA, a husband-wife team, beautiful. What happened was we were worried when we took oral testosterone.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

Testosterone, I can wait. And it was not available in America for 50 years. It was available in Europe. And a couple of researchers at UCLA, a husband-wife team, beautiful. What happened was we were worried when we took oral testosterone.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

Yeah, we'd go to the liver.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

Yeah, we'd go to the liver.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

Right, to the biliary system and go to the liver, cause liver cancer. So it was always verboten. Even though there was no evidence this was happening in Europe for 50 years. Yeah, not much. It's FDA approved. The EEA approved it. So this group came up with a way to get it metabolized through the lymphatics. So it could absorb through the lymphatic and never hits the liver. And it's really good.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

Right, to the biliary system and go to the liver, cause liver cancer. So it was always verboten. Even though there was no evidence this was happening in Europe for 50 years. Yeah, not much. It's FDA approved. The EEA approved it. So this group came up with a way to get it metabolized through the lymphatics. So it could absorb through the lymphatic and never hits the liver. And it's really good.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

I mean, there is a non-response rate of around 10%. So 10% of men, some like gels too, 15% won't respond. There's groups that won't respond that well, but it is really good.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

I mean, there is a non-response rate of around 10%. So 10% of men, some like gels too, 15% won't respond. There's groups that won't respond that well, but it is really good.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

Usually you don't want to do it right away too. So you want to give him a couple of weeks to stabilize hemostatically, right? But usually you can get pretty good levels because the half-life isn't that short. They say it peaks in five hours. So I don't know what the half-life is. Probably like 12, more like 12. You wouldn't dose it at 100% decay. You would dose it at 50%.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

Usually you don't want to do it right away too. So you want to give him a couple of weeks to stabilize hemostatically, right? But usually you can get pretty good levels because the half-life isn't that short. They say it peaks in five hours. So I don't know what the half-life is. Probably like 12, more like 12. You wouldn't dose it at 100% decay. You would dose it at 50%.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

So he's probably not responding. We can check it at different times, but it's probably not much of a response.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

So he's probably not responding. We can check it at different times, but it's probably not much of a response.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

It depends. I usually go to the mid-dose 298 twice a day. And then you can double it or whatever. I usually start out at not the lowest dose. And it depends what you're trying to solve too in the problem, right? If you want them, you're not going to get them to 800 or a thousand very easily. You can get them 400 to 600, 600, 700 pretty well, but no side effects.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

It depends. I usually go to the mid-dose 298 twice a day. And then you can double it or whatever. I usually start out at not the lowest dose. And it depends what you're trying to solve too in the problem, right? If you want them, you're not going to get them to 800 or a thousand very easily. You can get them 400 to 600, 600, 700 pretty well, but no side effects.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

I haven't seen anything that maybe a couple dozen men really well tolerated.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

I haven't seen anything that maybe a couple dozen men really well tolerated.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

I've never, no one tolerates that.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

I've never, no one tolerates that.