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716 total appearances

Appearances Over Time

Podcast Appearances

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

So it's a hormonal effect and a direct effect.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

So it's a hormonal effect and a direct effect.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

That's the worst player for me. So THC, same thing, count motility, morphology, and it probably has an effect. We know it has an effect on fragmentation, which is a quality measure of sperm, not only the way it looks descriptively, but quality, and also probably an epigenetic effect. Some of the early studies on sperm epigenetics showed alterations with nicotine and with pot.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

That's the worst player for me. So THC, same thing, count motility, morphology, and it probably has an effect. We know it has an effect on fragmentation, which is a quality measure of sperm, not only the way it looks descriptively, but quality, and also probably an epigenetic effect. Some of the early studies on sperm epigenetics showed alterations with nicotine and with pot.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

What I don't like about pot is you ingest it and however you ingest it, you get a peak, you feel it, it goes away, you feel it's out of your system like nicotine, but it sits in your fat for a month or three weeks and it's a depot effect and it keeps coming back. So you get a low level toxicity, which I don't like at all. So I am not a fan of pot.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

What I don't like about pot is you ingest it and however you ingest it, you get a peak, you feel it, it goes away, you feel it's out of your system like nicotine, but it sits in your fat for a month or three weeks and it's a depot effect and it keeps coming back. So you get a low level toxicity, which I don't like at all. So I am not a fan of pot.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

The other thing that really concerns me about pot and reproductive age men is I wrote a couple of blogs on this called The Weed Worries. And there's some compelling evidence from epidemiology and two studies 10 years apart validating each other that chronic pot use is associated with testis cancer.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

The other thing that really concerns me about pot and reproductive age men is I wrote a couple of blogs on this called The Weed Worries. And there's some compelling evidence from epidemiology and two studies 10 years apart validating each other that chronic pot use is associated with testis cancer.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

I mean, it's an interesting phenomenon. It's medical marijuana, right? So medical means safe. But I asked someone, I have a lot of pot growers in the Emerald City up in Northern California, and they have the artisanal stuff that wins awards and stuff. And it's like, which is worse for driving, being stoned or being drunk? undoubtedly being drunk. Yeah.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

I mean, it's an interesting phenomenon. It's medical marijuana, right? So medical means safe. But I asked someone, I have a lot of pot growers in the Emerald City up in Northern California, and they have the artisanal stuff that wins awards and stuff. And it's like, which is worse for driving, being stoned or being drunk? undoubtedly being drunk. Yeah.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

So it looks like reflexes, but you know, like he said to me, well, we tend to stop at stoplights and wait for them to turn when we're stoned.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

So it looks like reflexes, but you know, like he said to me, well, we tend to stop at stoplights and wait for them to turn when we're stoned.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

And I think the signs, the LA story signs, and they have the lit up signs about open season traffic and the movie LA story. They do say now drunk or stoned, watch out. We're going to get you.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

And I think the signs, the LA story signs, and they have the lit up signs about open season traffic and the movie LA story. They do say now drunk or stoned, watch out. We're going to get you.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

I don't think it's the root. So I don't think it's toking or edibles, but it might just be the chronic exposure. And I don't see, there's some evidence that THC acts like LH and binds the receptor and blocks it. But blocks it from LH.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

I don't think it's the root. So I don't think it's toking or edibles, but it might just be the chronic exposure. And I don't see, there's some evidence that THC acts like LH and binds the receptor and blocks it. But blocks it from LH.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

It's nicotine. Nicotine per se. Is the issue. And it doesn't last as long as THC. It does have count motility effects and fertility effects. We think probably both of these are oxidants.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

It's nicotine. Nicotine per se. Is the issue. And it doesn't last as long as THC. It does have count motility effects and fertility effects. We think probably both of these are oxidants.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

Probably all of them. I don't think we know exactly, but I'd say that I diagnosed diabetes in a lot of infertile men. I make the diagnosis.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

Probably all of them. I don't think we know exactly, but I'd say that I diagnosed diabetes in a lot of infertile men. I make the diagnosis.