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716 total appearances

Appearances Over Time

Podcast Appearances

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

So for me, it's usually their weight and their count maturity are low. I'm looking for a chronic exposure. And then they have polyuria or polydipsia or something like that, where they're drinking a lot and they're peeing a lot because the sugar is dragging it out and you check their UA and it's full of sugar. And then some of them have an A1C that's a little pre-diabetic.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

So for me, it's usually their weight and their count maturity are low. I'm looking for a chronic exposure. And then they have polyuria or polydipsia or something like that, where they're drinking a lot and they're peeing a lot because the sugar is dragging it out and you check their UA and it's full of sugar. And then some of them have an A1C that's a little pre-diabetic.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

But I think a lot of it is neurogenic too. They can develop an ED. A third of type 2 diabetics have low testosterone. So that's a clue. And that's secondary. So you can clone it. You can bend them right back. But that's probably the common one is the look, the sugars, and then the low T and the low sperm count.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

But I think a lot of it is neurogenic too. They can develop an ED. A third of type 2 diabetics have low testosterone. So that's a clue. And that's secondary. So you can clone it. You can bend them right back. But that's probably the common one is the look, the sugars, and then the low T and the low sperm count.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

You can develop varicose veins in your leg and need treatment. And this is the same thing in the scrotum, but it's not related. And it happens typically at puberty. You'll develop this. You won't know it sometimes unless it hurts. It's a reflux of blood in the wrong direction. So the testicle drains to the kidney, which is uphill, and it wants to drain back down.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

You can develop varicose veins in your leg and need treatment. And this is the same thing in the scrotum, but it's not related. And it happens typically at puberty. You'll develop this. You won't know it sometimes unless it hurts. It's a reflux of blood in the wrong direction. So the testicle drains to the kidney, which is uphill, and it wants to drain back down.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

The reason why it drains back down is because as a species, we stood up a half a million years ago, maybe three quarters of a million years ago. And when you're an animal, your kidney and your testicle drains this way. There's no gravity. But when you stand up, you're now draining uphill. The system was never made for valves. And if you said to me, what's the reason our sperm counts are falling?

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

The reason why it drains back down is because as a species, we stood up a half a million years ago, maybe three quarters of a million years ago. And when you're an animal, your kidney and your testicle drains this way. There's no gravity. But when you stand up, you're now draining uphill. The system was never made for valves. And if you said to me, what's the reason our sperm counts are falling?

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

I would say, we stood up as a species. Probably not a good idea for male fertility because that would... that's supposed to be staying up there, comes back down to the testicle, pulls around it like a hot bath, is warmer. And usually the first sign is a testicle on that side, which is the left, usually is smaller than the right. So the physical exam will reveal a testicular discrepancy in size.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

I would say, we stood up as a species. Probably not a good idea for male fertility because that would... that's supposed to be staying up there, comes back down to the testicle, pulls around it like a hot bath, is warmer. And usually the first sign is a testicle on that side, which is the left, usually is smaller than the right. So the physical exam will reveal a testicular discrepancy in size.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

That's the first thing you see. And then you feel above it and you feel a bag of worms.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

That's the first thing you see. And then you feel above it and you feel a bag of worms.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

But there might be a few during puberty, but the growth spurt, those blow the angle of the renal vein and there's a right angle. The right side has a natural valve off the vena cava. So it's kind of has to go around 270 degrees. So you don't reflux on the right. Left-sided lesion in most men. You can be perfectly fertile with it.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

But there might be a few during puberty, but the growth spurt, those blow the angle of the renal vein and there's a right angle. The right side has a natural valve off the vena cava. So it's kind of has to go around 270 degrees. So you don't reflux on the right. Left-sided lesion in most men. You can be perfectly fertile with it.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

If you look at statistically, 85% of men conceive naturally without varicoceles, 80% will conceive naturally about a year. So the curves are very similar. Clinically, maybe insignificant, but there is a difference and it's statistical. But if you multiply that by millions of people, it becomes important. And you'll figure that out easily on a physical exam? The best way is easy.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

If you look at statistically, 85% of men conceive naturally without varicoceles, 80% will conceive naturally about a year. So the curves are very similar. Clinically, maybe insignificant, but there is a difference and it's statistical. But if you multiply that by millions of people, it becomes important. And you'll figure that out easily on a physical exam? The best way is easy.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

I don't order ultrasound. If I can palpate it, then it's clinical. That's an office repair? It's an outpatient surgery. It takes an hour. We do microsurgery.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

I don't order ultrasound. If I can palpate it, then it's clinical. That's an office repair? It's an outpatient surgery. It takes an hour. We do microsurgery.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

So it's more involved than a vasectomy. Yes, it is. And you're doing it at microsurgery at the level where you don't cut muscle. You want him to recover quicker. It's an involved area with lots of veins. But he's not under general. I use twilight sedation. Yep. So that's the most common.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

So it's more involved than a vasectomy. Yes, it is. And you're doing it at microsurgery at the level where you don't cut muscle. You want him to recover quicker. It's an involved area with lots of veins. But he's not under general. I use twilight sedation. Yep. So that's the most common.