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716 total appearances

Appearances Over Time

Podcast Appearances

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

And he had like 2,000 all mammalian viruses on his chip. Everything. And we ran fertile guys and we ran infertile guys and looked at semen, not sperm. And 99% of the infertiles were positive for something and 98% of the normals were positive for something. So ubiquitous was the word. And so it left us high and dry because you can't really do much with that. So it's out there.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

And he had like 2,000 all mammalian viruses on his chip. Everything. And we ran fertile guys and we ran infertile guys and looked at semen, not sperm. And 99% of the infertiles were positive for something and 98% of the normals were positive for something. So ubiquitous was the word. And so it left us high and dry because you can't really do much with that. So it's out there.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

But I do agree with your assessment that the pathologic phenotypes, the worst ones, are probably doing something. The question is, how do we measure it? What do we look for? And with semen analysis, as I said earlier, it's a blunt instrument. It varies a lot. It's tough to do it, but I'd love whether we do genotyping on recent sperm, probably not. I don't know.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

But I do agree with your assessment that the pathologic phenotypes, the worst ones, are probably doing something. The question is, how do we measure it? What do we look for? And with semen analysis, as I said earlier, it's a blunt instrument. It varies a lot. It's tough to do it, but I'd love whether we do genotyping on recent sperm, probably not. I don't know.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

And when you look at HPV, it's probably one of those things that might be in the ejaculate after ejaculation. might be coming from another fluid source and not in the sperm itself. So its effect would be post-ejaculation, which could still have a fertility effect, but it won't be probably as deep.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

And when you look at HPV, it's probably one of those things that might be in the ejaculate after ejaculation. might be coming from another fluid source and not in the sperm itself. So its effect would be post-ejaculation, which could still have a fertility effect, but it won't be probably as deep.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

I mean, the problem with the male system is it's all through the same tube. So urine comes through that tube and semen comes through that tube. So you have to look for infections in the urinary tract and anything like that when you're doing fertility because pus cells kill whatever they see. So if your urine's infected, that's a big deal.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

I mean, the problem with the male system is it's all through the same tube. So urine comes through that tube and semen comes through that tube. So you have to look for infections in the urinary tract and anything like that when you're doing fertility because pus cells kill whatever they see. So if your urine's infected, that's a big deal.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

Not a big fan. As a trained stem cell biologist and someone trying to make sperm from skin and working with some of the best stem cell scientists in the world, I have a lot of respect for them, but it's not that simple. There's 560 offshore stem cell companies in the world that will take your money and do things like stick PRP in there. They'll stick bone marrow aspirates fat in your testicle.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

Not a big fan. As a trained stem cell biologist and someone trying to make sperm from skin and working with some of the best stem cell scientists in the world, I have a lot of respect for them, but it's not that simple. There's 560 offshore stem cell companies in the world that will take your money and do things like stick PRP in there. They'll stick bone marrow aspirates fat in your testicle.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

And I'd say my experience has not been favorable. Some of the toughest cases in the world and they come to me after that and I do my techniques and I don't find anything and the trials aren't really real. come here, we're going to do this, and then we're going to do a microdissection on your testicle, but they didn't have one beforehand.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

And I'd say my experience has not been favorable. Some of the toughest cases in the world and they come to me after that and I do my techniques and I don't find anything and the trials aren't really real. come here, we're going to do this, and then we're going to do a microdissection on your testicle, but they didn't have one beforehand.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

So the chance of finding it even without that is X and they're finding X. So it's just not well done. And I have my patients investigate all that. And I say, you do the work. You tell me who you found. Let me call them. I'll let them be the workers. And then I'll call them and I'll say, hi, I was just wondering about, do you have any papers or what's the science behind it?

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

So the chance of finding it even without that is X and they're finding X. So it's just not well done. And I have my patients investigate all that. And I say, you do the work. You tell me who you found. Let me call them. I'll let them be the workers. And then I'll call them and I'll say, hi, I was just wondering about, do you have any papers or what's the science behind it?

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

And they usually hang up or it's really interesting. But so far I'd say it's unfounded.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

And they usually hang up or it's really interesting. But so far I'd say it's unfounded.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

And I would say the answer is most. Wow. But the caveat is you got to tell me about the woman because I will defer. This is the only data I can give you. So I did a paper where I saw men for their infertility evaluation, got it done. And I thought they were fine. They had varicoceles and stuff, but their semen analysis was normal. And my investigation of their risk lifestyle, everything was good.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

And I would say the answer is most. Wow. But the caveat is you got to tell me about the woman because I will defer. This is the only data I can give you. So I did a paper where I saw men for their infertility evaluation, got it done. And I thought they were fine. They had varicoceles and stuff, but their semen analysis was normal. And my investigation of their risk lifestyle, everything was good.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

And I said, you're fine. You're cleared. No one's ever said that before. And they went home and they said, Turk couldn't figure out what's wrong with us. I said, that's not what I said. I don't do women. My expertise, I'm saying something positive here. Most people would say, I'm not sure why you're not conceiving. I said, I'm pretty sure you're not the problem. Didn't get interpreted like that.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

And I said, you're fine. You're cleared. No one's ever said that before. And they went home and they said, Turk couldn't figure out what's wrong with us. I said, that's not what I said. I don't do women. My expertise, I'm saying something positive here. Most people would say, I'm not sure why you're not conceiving. I said, I'm pretty sure you're not the problem. Didn't get interpreted like that.