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716 total appearances

Appearances Over Time

Podcast Appearances

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

Two-thirds will improve, one-third or more will conceive naturally. So you could take guys with low sperm counts and you can fix them or not, but the driver's genetics. And the phenotype in offspring is simply inherited as a Y chromosome deletion. It'll either be, I just had a couple from Texas, actually. He had a Y chromosome deletion. He conceived with help of technology with a low sperm count.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

Two-thirds will improve, one-third or more will conceive naturally. So you could take guys with low sperm counts and you can fix them or not, but the driver's genetics. And the phenotype in offspring is simply inherited as a Y chromosome deletion. It'll either be, I just had a couple from Texas, actually. He had a Y chromosome deletion. He conceived with help of technology with a low sperm count.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

Sons have it. They have no sperm. So you can inherit the deletion, but it might increase. So you're going to get what your dad had, or it might be worse because mutations tend to get larger.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

Sons have it. They have no sperm. So you can inherit the deletion, but it might increase. So you're going to get what your dad had, or it might be worse because mutations tend to get larger.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

Yeah, that's a big one. in terms of the percent of sperm with the lifestyle issues. And then lousy diet is probably something that, so obesity and diet, lifestyle, recreational drugs. What else do I review with them? Toxic exposures at work. So any smelly solvents, I'm really worried. Some airport fuels, airline stuff, machine shop oils, anything benzene derivatives.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

Yeah, that's a big one. in terms of the percent of sperm with the lifestyle issues. And then lousy diet is probably something that, so obesity and diet, lifestyle, recreational drugs. What else do I review with them? Toxic exposures at work. So any smelly solvents, I'm really worried. Some airport fuels, airline stuff, machine shop oils, anything benzene derivatives.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

Used to be pesticides and stuff like that, but they're pretty well controlled. So environmental exposures are kind of an unknown. I think viruses have a role. That's how you recently wrote about HPV. And I've been thinking about that for years because there are men, it used to be half the men who came in when I entered the field 30 years ago, we didn't know what was going on with them.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

Used to be pesticides and stuff like that, but they're pretty well controlled. So environmental exposures are kind of an unknown. I think viruses have a role. That's how you recently wrote about HPV. And I've been thinking about that for years because there are men, it used to be half the men who came in when I entered the field 30 years ago, we didn't know what was going on with them.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

But now it's probably 10 or 20% with lifestyle issues and stuff like that. You can pretty much sort it out. It's not that unknown. But there are men who are like, what is going on here? He's a perfectly healthy guy. Practicing in California is incredible because everyone's so healthy, you have to look elsewhere. You have to ask other questions.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

But now it's probably 10 or 20% with lifestyle issues and stuff like that. You can pretty much sort it out. It's not that unknown. But there are men who are like, what is going on here? He's a perfectly healthy guy. Practicing in California is incredible because everyone's so healthy, you have to look elsewhere. You have to ask other questions.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

And when there's obesity, it's always the elephant in the room, but everyone is so healthy in eating. So I get to poke around places where no one else goes because I have to explain it and there's nowhere to go. But I did a study. So HPV is the most common. You wrote about that. Is that What's the link? It's hard to know. There's herpes, very common.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

And when there's obesity, it's always the elephant in the room, but everyone is so healthy in eating. So I get to poke around places where no one else goes because I have to explain it and there's nowhere to go. But I did a study. So HPV is the most common. You wrote about that. Is that What's the link? It's hard to know. There's herpes, very common.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

The STDs that we know about, like the 11 common beasts, chlamydia and gonorrhea and syphilis, those we know a little more about, and they're pretty obvious. But some of these trichomonas and stuff are pretty subtle. really concerned about this because one guy 20 years ago, and now it's a professor at UCSF, he sent me a picture of electron photograph of a sperm with a hexagonal herpes virus in it.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

The STDs that we know about, like the 11 common beasts, chlamydia and gonorrhea and syphilis, those we know a little more about, and they're pretty obvious. But some of these trichomonas and stuff are pretty subtle. really concerned about this because one guy 20 years ago, and now it's a professor at UCSF, he sent me a picture of electron photograph of a sperm with a hexagonal herpes virus in it.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

And I don't even know if it was Photoshop, but there's this virus in a sperm. I'm like, yeah, it looks like there's a virus in that sperm. You think that's what's causing it? I said, I don't know. I don't know. But normally when you see infections as a cause, viral or bacterial, as a cause of semen analysis, you'll see pus cells.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

And I don't even know if it was Photoshop, but there's this virus in a sperm. I'm like, yeah, it looks like there's a virus in that sperm. You think that's what's causing it? I said, I don't know. I don't know. But normally when you see infections as a cause, viral or bacterial, as a cause of semen analysis, you'll see pus cells.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

So you'll see what's called pyospermia, leukocytospermia, the round cells we talked about. And the semen analysis will show up in higher numbers. They tend to be destructive and they tend to lower motility. So you tend to see a certain look to the semen analysis, volume, normal count. Motility is really low.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

So you'll see what's called pyospermia, leukocytospermia, the round cells we talked about. And the semen analysis will show up in higher numbers. They tend to be destructive and they tend to lower motility. So you tend to see a certain look to the semen analysis, volume, normal count. Motility is really low.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

A lot of the sperm are dead because they've been wiped out by these cytokines and all the white cells. And then maybe you'll find the pathogen somewhere. But culturing, mycoplasma, CMV, all these viruses. So Joe DeRisi, really bright guy, UCSF, went to MacArthur Ward. He took my patient's semen. This was back when microwaves were popular in the 2000s.

The Peter Attia Drive
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.

A lot of the sperm are dead because they've been wiped out by these cytokines and all the white cells. And then maybe you'll find the pathogen somewhere. But culturing, mycoplasma, CMV, all these viruses. So Joe DeRisi, really bright guy, UCSF, went to MacArthur Ward. He took my patient's semen. This was back when microwaves were popular in the 2000s.