Paul Turek

And that's based on the New England Journal paper where they looked at, I think, 700 couples and they had them keep diaries. It was a Boston-based paper. Keep diaries of how they had sex, when they ovulated, and when they got pregnant. And then they said, do what you normally do and then give us the diaries.

And that's based on the New England Journal paper where they looked at, I think, 700 couples and they had them keep diaries. It was a Boston-based paper. Keep diaries of how they had sex, when they ovulated, and when they got pregnant. And then they said, do what you normally do and then give us the diaries.

And then they evaluated them and they found that having sex, say ovulation is day 15 of the cycle. When they started having sex on 9, 11, 13, there were significant pregnancy rates. And every other day was the optimal interval. But even five days before and three days before, there were substantial pregnancy rates. before ovulation.

And then they evaluated them and they found that having sex, say ovulation is day 15 of the cycle. When they started having sex on 9, 11, 13, there were significant pregnancy rates. And every other day was the optimal interval. But even five days before and three days before, there were substantial pregnancy rates. before ovulation.

But if you waited to ovulation and then had sex, that's about 20% of conception. So when you get the kit, don't react to it. Predict in front of it. So front load the sex. Very important. And why is that? Is that because... There's a reservoir effect in this uterus. It's managed. Sperm will survive for a day or two.

But if you waited to ovulation and then had sex, that's about 20% of conception. So when you get the kit, don't react to it. Predict in front of it. So front load the sex. Very important. And why is that? Is that because... There's a reservoir effect in this uterus. It's managed. Sperm will survive for a day or two.

Remind me where the oviduct is. So there's the uterus and the fallopian tubes.

Remind me where the oviduct is. So there's the uterus and the fallopian tubes.

And that's the oviduct. The oviduct is right below where the ovaries sit.

And that's the oviduct. The oviduct is right below where the ovaries sit.

They bind to the endothelium and just park.

They bind to the endothelium and just park.

80% of conceptions naturally or at home occur when sex is front-loaded as opposed to reacting to ovulation. And most of the apps that are available nowadays will tell you that. Peter, you're drawing a graph. I am. I have to draw.

80% of conceptions naturally or at home occur when sex is front-loaded as opposed to reacting to ovulation. And most of the apps that are available nowadays will tell you that. Peter, you're drawing a graph. I am. I have to draw.

There was a study that showed how long it took to make a sperm. And it was published in Science, I think, in the 60s. And they gave men tritiated water. They gave men radioactive hydrogen. And then they biopsied their testicles, which could never be done nowadays. But I did it all different. I gave deuterated water with a group at Berkeley, and we gave healthy men deuterated water for a week.

There was a study that showed how long it took to make a sperm. And it was published in Science, I think, in the 60s. And they gave men tritiated water. They gave men radioactive hydrogen. And then they biopsied their testicles, which could never be done nowadays. But I did it all different. I gave deuterated water with a group at Berkeley, and we gave healthy men deuterated water for a week.

That's wild. But that was the best data. And we did deuterated water, which is not radioactive, and we could measure that. So we gave them a dose and then we watched their ejaculates weekly. And we looked for when deuterated, the hydrogen showed up in the DNA. And it was an average of 74 days. So normally say three months to make a sperm.

That's wild. But that was the best data. And we did deuterated water, which is not radioactive, and we could measure that. So we gave them a dose and then we watched their ejaculates weekly. And we looked for when deuterated, the hydrogen showed up in the DNA. And it was an average of 74 days. So normally say three months to make a sperm.

So some went for 42 days, and that's going through the epididymis and getting ejaculated. We talked about maybe two months in the testis and two weeks, a week or two in the epididymis, and then maybe a couple of weeks to ejaculate. And this was all the average 74 days. So it actually changed the timeline enormously to a much faster one. So 74 days.

So some went for 42 days, and that's going through the epididymis and getting ejaculated. We talked about maybe two months in the testis and two weeks, a week or two in the epididymis, and then maybe a couple of weeks to ejaculate. And this was all the average 74 days. So it actually changed the timeline enormously to a much faster one. So 74 days.