Paul Turek
speaker
358 appearances
1 recordings
1 series
first heard Jun 2025
last heard Jun 2025
Paul Turek’s voice in public audio — every appearance, attributed to the second.
Trend
recordings per month · last 12 monthsNo recordings in the last 12 months.Older appearances are listed below; set an alert to hear about the next one.
Appearances
So if there's too much estradiol, the brain senses it's a negative feedback, senses, hey, there's too much of this, so let's make less testosterone. So it will lower your testosterone to have high estradiol. When estradiol is made, it gets metabolized differently than testosterone. It goes to the liver or to fat.
And aromatases convert it to something else, or testosterone gets converted to female hormone aromatases. So you can get high levels being obese or having liver dysfunction, so alcohol, alcoholic cirrhosis, hepatitis. It'll rev it up and it'll make a lot more estradiol level. And there's some medications that do it too.
And that will act and lower your testosterone, which will lower sperm production because you're not watering the plant.
If you see that there's a low count and the testosterone's low, and you could say you need to lose 100 pounds. which is the key secret for everything, right? But you can also give aromatase inhibitors like weightlifters use to keep their levels down. Okay.
So I usually do two semen analyses three weeks apart or more to get a sense of things because it varies quite a bit. So a very important point is that the semen analysis, any feature of that semen analysis vary by 50 to 100%.
So I do a lot of consulting for the FDA and they do medications in reproductive age men and they're trying to show the semen analysis. They're going to the FDA and they're saying, can you help us interpret this data for the FDA? I said, garbage in, garbage out. I mean, there's so much variability, you really can't say anything. So you have to do at least two samples.
And it still varies quite a bit. There's inter-observer variability, who does the semen analysis. There's biological variability on what your system's like. So that's the big problem with studies.
If they do, they'll do animal models. They won't do human studies, they'll do animal models. They'll do beagles, mice and beagles. And if there's no fertility effects, they don't really look at semen analysis in those. They'll look at fertility effects in the animals. If there's nothing there, then they'll probably not require human studies.
If there's any suggestion of a problem in the animal models, which is a million dollars of work. So if you ask me why I patented the Somatic Colonial Stem Cell, I want an in vitro test for human infertility that we could use instead of animal models, save the animals, save a million dollars, do an in vitro spermatogenesis model and see if there's an effect at all.
Absolutely.
And you know, there are 80,000 chemicals out there that are not been studied reproductively that are commonly in use in industry. European commissions are a little better off. They've screened them and they've warned about them, but America, mm-mm. Why is that? I don't know. It's attention to detail. It's one of those things that just doesn't, I don't know. Is it under the purview of the FDA?
Or the EPA? Probably a combination or maybe everyone's thinking it's the other person's job. I'm not sure, but they're untested and they're out there.
So, although sperm are made constantly and are susceptible to that, we know the testicle is a pretty good place, excuse me, and insulated from exposures. I also think there's a lot of smoke there and it needs to be sorted out, but especially with the 80, 60 to 80,000 chemicals that are being used that aren't really tested at all.
I think the only way to know is to do stem cell in vitro testing as much as you can before you put it on at the ID investigational drug stage, not at the final stages for clinical trials, but early on do it. So you're screening way in advance of getting into clinical trials and where the money gets big.
But I think that there are windows of susceptibility in men, unlike maybe with women whose eggs are constantly exposed to toxins. men have windows. And one of those windows is birth and early development, the first 12 weeks of life. That early? When all organ systems are developing, including testicles. I mean, Shauna Swan did this one with maternal beef consumption, estrogenized beef consumption.
Their sons had lower sperm counts when they were 20 years later or something. So I think that's a window of susceptibility. I also think puberty is a window of susceptibility when things turn on So I think if exposures in those moments are probably going to matter the most to men, I don't know about other times.
And I think the stress- Counterbalances any amount of microplastics you save. Double the stress in a man and testosterone level will fall. And then the sperm production falls for a whole different reason.
33.
So what does stress do? Stress is the sympathetic nervous system. It's fight or flight. You're running from a woolly mammoth. It doesn't know what you're running from. It doesn't know whether it's sleep or travel or financial or emotional. It's just the body. We are cats and dogs. We have the same binary nervous system. Either you're on or you're off. And when you're on, do you want testosterone?
No, you want cortisol. You're running for your life. And do you want fertility when you're running for your life in any species? No, you're trying to save your life. So cortisol goes on, testosterone is nowhere to be found, fertility is nowhere. You turn off all that stuff.
Showing 141–160 of 358 · page 8 of 18
← Previous
Next →