The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.
In terms of being a productive non-assholic member of society and not being overly aggressive or engaging in harmful behavior, risky behavior, what's the pro and con case for that in your mind?
The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.
Yeah, the most complicating thing, if I could wave a magic wand, wave one magic wand in medicine right now, what would I have?
The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.
I would have a PSA equivalent for breast cancer.
The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.
Come back to why that would be a game-changing solution down the line.
The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.
The second thing, which would not be nearly as important, would be I would love to have an assay to measure androgen receptor density.
The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.
Because what we can't, we tell all our patients this, they look at us like, just measure it.
The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.
And I'm like, no, no, you don't understand.
The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.
We don't have a test for it.
The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.
And they're like, how do you not have a test for this?
The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.
I mean, I guess you could.
The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.
Is there a commercial test for that?
The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.
I mean, you can do that in the lab.
The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.
Someone should develop a CLIA-approved assay for this.
The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.
But the point I really want to make is, why is it that one guy can have a testosterone of 400 and feel totally fine, and another guy can have a testosterone of 400 and feel totally depleted?
The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.
And if you took both of those guys up to 1,000, the first guy would be like, I don't feel any better.
The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.
And the second guy would be like, you've changed my life.
The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.
No, you can't, but you can just change one variable at a time.
The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.
Typically, tea won't fix a lot of those things.
The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.
The most obvious things you try to fix are sleep, nutrition, and exercise.
The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.
Regardless of what his testosterone level is, if it's 400, which is very low, especially if his free testosterone is equivalently low, and he's got these vague symptoms, it's like, well, look, if you're not sleeping well, eating well, and exercising well, let's fix those first.