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Peter Attia, M.D.

๐Ÿ‘ค Speaker
589 total appearances

Appearances Over Time

Podcast Appearances

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

Yeah, sure, absolutely.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

But you can't always fix those things to the nth degree without wanting to at least experiment, especially when it comes to body composition stuff or energy levels.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

So by making the one variable change at a time, you can say, look, let's do the experiment.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

If your T is now 900...

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

And we haven't made a change during that period of time other than that T. And you're telling me, I don't really feel that much different.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

My hypothesis is you have a pretty low density of androgen receptors, and they're largely saturated at 400.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

And therefore, this isn't really the fix.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

There's something else we need to be looking at.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

Sorry, just to be clear, you were on hormone replacement therapy prior to?

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

No.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

Okay.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

Even though you were already in menopause.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

So why did you decide to only go on hormone replacement therapy at the age of 57 when presumably you believed you were in menopause prior and didn't go on HRT?

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

You look like you've been at it for years.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

And it sounds like you feel better as a result of it.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

Yeah, that's an interesting point because, as you know, but maybe some of the listeners don't, testosterone is a regulated, scheduled drug hormone, whereas estrogen is not.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

Estrogen can be prescribed without any DEA scheduling.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

Testosterone is a schedule.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

I believe it's a schedule for testosterone.

The Peter Attia Drive
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

But that's an interesting point that you raise, right?