Peter Attia, M.D.

Yeah.

And by the way, at any point, is any of this testosterone being converted to DHEA in any meaningful amount?

Sorry, I meant DHT.

I've never thought about this until now.

Is that why DHT has such a high affinity for the androgen receptor, you think?

Yes.

Is so that you could permit it to only have a local effect during embryologic development?

Because otherwise, I don't know that it would matter as much in me at this old age that DHT is that much more potent than testosterone.

I'm okay to be exposed to circulating androgens in a way that the fetus presumably you wouldn't want.

Oh, I thought it was even more than that.

Unfortunately, these are really, really rare conditions.

It's funny, in medical school, you come away thinking these things occur all the time because of how much time you spend studying these very, very rare disorders.

But again, fortunately, they're not common.

Going back to that specific case, you have an individual that is born that I assume at birth looks female.

Right, because they look male everywhere else, right?

But do they have ovaries?

But they haven't descended?

Yeah, they're producing totally normal testosterone levels.

Yes.

Just not DHT.