Peter Attia

Taking a high-quality EPA and DHA supplement is a great way to supplement the amount of fish we eat.

Maybe another one I would throw in there is for jet lag.

I think melatonin can be very helpful.

I'm not a fan of it at all for daily use because it does seem to downregulate endogenous production of melatonin.

But when you're hopping, in my experience, more than six or seven hours of a time zone, melatonin can be a wonderful tool to help reset circadian rhythm, along with another supplement that I only use during those periods, which is called phosphatidylserine.

Phosphatidylserine suppresses cortisol output from the adrenal glands and also is just a fantastic tool when you're trying to go to bed.

Oh, it's not even close, Stephen.

The advantage that we would have when assessing the benefits of a GLP-1 agonist are so much more because the studies are so much larger, they're so much more robust.

It's interesting that you brought up GLP-1s because everybody understands the efficacy that these drugs have when it comes to weight loss and type 2 diabetes.

But there are all sorts of sub-analyses that are looking at other questions, right?

How does this drug stack up in patients with heart failure?

How does this drug stack up in patients with MCI or mild cognitive impairment?

It is that indication of MCI that I think is the most interesting right now.

Because the jugular question is not, does a person who is obese, overweight, or have type 2 diabetes who takes this drug and therefore ameliorates those conditions, does that improve MCI?

The answer is obviously yes, it does.

Because anything that takes weight off and improves insulin sensitivity improves cognitive function.

The more important question, and the multi-billion dollar question is,

independent of the weight loss and the improving insulin sensitivity, do these things improve cognition?

And if the answer to that is yes, we would elevate this drug from its current status into the pantheon of what we call geroprotective agents, right?

Something that is actually targeting some of the fundamental metrics of aging and not doing it circuitously through weight loss or insulin sensitivity, all of which are important, but they're very distinct questions.