Peter Attia

I want to come back and talk about a lot of these things, but I feel like we should now get people up to speed on what ketones are.

Again, we can sit here and talk about this and take this stuff for granted all day.

You obviously threw around the term nutritional ketosis.

You've also talked about supplemental ketosis, sometimes referred to as exogenous ketones.

Let's start with nutritional ketosis and just give people some definitions of how you achieve it, how much variability there can be in a diet to get there, what the thresholds are, and a little bit about what's happening physiologically.

Let's talk a little bit about that.

You've mentioned it a few times now.

So let's help folks understand what's going on here.

So this was first identified in kids.

So what gave them the idea?

We defaulted.

Hey, we've got these people that are experiencing this awful thing.

Now they had EEGs back then, but they really didn't know much.

And when were these first identified?

So you've got Banting and Best identify insulin or at least isolate insulin in the 1920s.

Yes.

So that's really, in my mind, I think of that as kind of the golden era of metabolism.

When were ketones first isolated, BHB specifically?

They didn't understand why.

Mechanistically, I mean.