PJ Vogt

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So can you tell me literally just like what are GLP-1s doing inside of your body?

Like what are the mechanics of how these drugs work?

Yes.

Like, not just the feeling of being full, but literally, like, if I eat a salad, it stays there.

Yeah.

And what's the relationship between, like glucose enters my body when I eat like sugar or bread or something like that.

What's the relationship between glucose and insulin?

There's no reason to think that if I'm 225 pounds or 180 pounds, I should want to drink more or less.

And is it like these sort of unexpected positive effects, the ones that are sort of surplus effects that go beyond what you would have modeled as likely benefits of just like losing weight?

Does it suggest that maybe being like a certain amount of overweight can be more dangerous to our health than we understood?

Or is it more like these things are just doing things in places that we don't understand?

Yeah.

You've described...

the known benefits, you described that there's some like sort of, I don't wanna say unknown possible benefits, but like question-marky things that look good.

And what are the current unknown or questionable possible harms that you're tracking?

Right.

Because there's people that can't tolerate the side effects.