Professor John Amory
speaker
76 appearances
1 recordings
1 series
first heard May 2026
last heard 1 May
Professor John Amory’s voice in public audio — every appearance, attributed to the second.
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Appearances
Good morning.
A great question.
There's a bunch of us, endocrinologists and urologists and medical doctors all around the world that have been working on developing novel methods of male contraception for almost 50 years.
It's proven to be very challenging for a variety of reasons.
In contrast to women, there's no period where men are not fertile after they go through puberty.
Women don't produce eggs while they're pregnant.
And what female contraceptives largely do is mimic that state of pregnancy to turn off ovulation.
Men don't have an analogous period where they're not making sperm.
So turning off sperm production, a thousand sperm made every second, has proven to be somewhat difficult.
Well, the fun part of the story is it actually started even before we had female contraceptives.
So as early as the 1950s, there were efforts on parts of several investigators to develop male contraceptives, and they succeeded to a degree.
But the medications had significant side effects.
And so when the female pill was introduced in 1961, they were largely abandoned.
efforts restarted in the 80s, largely led by the World Health Organization, after it was acknowledged that administration of testosterone would largely suppress sperm production in a majority of men around the world.
This led to two large multi-center trials funded by the World Health Organization that were published in the 80s and 90s.
That didn't make it to the market for a couple reasons.
First of all, testosterone largely has to be administered by injection.
weekly injection in this case in the muscles, which was not super popular with the study subjects.
And we don't know why there's a subset of men who don't respond and we don't know how to identify them a priori.
The field has moved away from the injections, which need to be administered in a doctor's office, to self-administration of a daily gel.
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