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Professor Luke O'Neill

๐Ÿ‘ค Speaker
827 total appearances

Appearances Over Time

Podcast Appearances

Show Me the Science with Luke O'Neill
The Science of Gut Health

And maybe we'll go from a 20% response to a 40% response.

Show Me the Science with Luke O'Neill
The Science of Gut Health

Very exciting part of research.

Show Me the Science with Luke O'Neill
The Science of Gut Health

Now, the last thing to mention on this, which I'll spend a little bit of time on because it's interesting, and it gets a bit nasty.

Show Me the Science with Luke O'Neill
The Science of Gut Health

You're going to go, oh, that sounds terrible.

Show Me the Science with Luke O'Neill
The Science of Gut Health

Now, what this is, is can you take the stool, we'll call it that, from someone and then make a drink out of it and give it to someone else?

Show Me the Science with Luke O'Neill
The Science of Gut Health

Now, the Chinese have been doing this for hundreds of years, it turns out.

Show Me the Science with Luke O'Neill
The Science of Gut Health

It's called a fecal microbiota transplant or FMT.

Show Me the Science with Luke O'Neill
The Science of Gut Health

And that fecal microbiota will have the right composition to help you respond to certain things.

Show Me the Science with Luke O'Neill
The Science of Gut Health

Now, what are they doing here?

Show Me the Science with Luke O'Neill
The Science of Gut Health

This sounds most unusual.

Show Me the Science with Luke O'Neill
The Science of Gut Health

They're finding people with cancer who do respond to these immunotherapy approaches, right?

Show Me the Science with Luke O'Neill
The Science of Gut Health

And then they figure out the certain bacteria in that person's gut that's increasing their responsiveness.

Show Me the Science with Luke O'Neill
The Science of Gut Health

And they're making a tablet out of that fecal material from that person who's responsive, giving it to someone else, and then testing the immunotherapy.

Show Me the Science with Luke O'Neill
The Science of Gut Health

In other words, you're identifying responders and they're responding partly because of the right bugs in their gut and you're transferring those bugs to someone else to increase their responsiveness.

Show Me the Science with Luke O'Neill
The Science of Gut Health

Doesn't that sound rather peculiar?

Show Me the Science with Luke O'Neill
The Science of Gut Health

But as I say, this big thing in nature medicine that just came out, three papers back to back.

Show Me the Science with Luke O'Neill
The Science of Gut Health

There were two papers on kidney cancer and one on lung.