Rhonda Patrick, Ph.D.

But yeah, there is a genetic component and there's other environmental factors that play a role as well.

Really good points, Brady.

I 100% agree.

I mean, I think that's probably really tied into the reduction in all-cause mortality.

And it's also one of the big reasons why I engage in CrossFit.

I do a lot of CrossFit types of training because I'm getting the...

functional, I'm getting the explosive power, I'm getting the strength, you know, I'm doing all that type of resistance training, but it's mixed in with aerobic and these high intensity vigorous, you know, types of workouts.

And so you're really just getting it all.

And for me, it's a very time efficient, great way to get

the whole shebang, right?

It's not just the cardiorespiratory improvements, but also the effects on the muscle improvements and muscle health and strength as well.

So the other thing that I wanted to mention with respect to the adaptations was inflammation, right?

I mean, so the more

intense the the exercise stimulus you're in you're actually generating inflammatory compounds il-6 being like the big one and and that il-6 is is actually a signals to you know have this anti-inflammatory response so it's funny if you look at the curves you'll see like a timing effect where it's like il-6 peaks and then like it shifts like i don't remember how much later it is maybe an hour or so you start to see il-10 which is an anti-inflammatory cytokine

I'm not talking about in this study.

I'm talking about other studies that have looked at inflammatory biomarkers.

But you'll see this strong anti-inflammatory response.

And this is part of that, you know, something I've talked about before in the podcast for several years is this hormetic response where you're engaging in this type of response.

stressful activity which in this case we're talking about physical activity and the more vigorous it is the more stressful it is and that is a stress on the body and that does cause inflammation it does cause oxidative stress it's causing it's a stress on the body but your body is able to adapt to that and the adaptations is really what we're going for right and so the stronger you're getting this inflammatory response the

You're getting that anti-inflammatory response that then lasts, right?