Rhonda Patrick

We don't have a repair system for, like, we don't have a DNA repair system.

We have DNA in our mitochondria, but we don't have the same types of repair systems as we do in our nuclear genome.

So mitochondria repair themselves through a variety of mechanisms.

One of them is mitophagy, where a

portion of the mitochondria will be recycled or perhaps even the entire mitochondria if the entire mitochondria is damaged.

It seems as though the more vigorous the exercise, the more intense the exercise, the increased prevalence that you have of mitophagy happening.

So again, it doesn't mean that zone two type of training isn't having that happen as well, but you probably just have a larger volume of that before you get there.

So then there's this whole area of fat burning.

And you discussed this a little bit earlier and Dr. Kabbalah discussed this.

where what type of exercise is better for fat burning, right?

Well, mitochondria are at the center of burning fat, right?

So fatty acids are oxidized in the mitochondria.

So you hear a lot about zone two training and how zone two training is really ideal for optimizing fat burning.

Maybe you can talk a little bit about, maybe recap a little bit about what Dr. Gbala was saying with respect to how high intensity interval training affects fat utilization and how that compares to perhaps a low to moderate intensity type of training like zone two training.

Right.

It comes down to that adaptation, right?

When you're pushing beyond the capacity of your body's ability to bring nutrients and oxygen to the mitochondria to be oxidized for energy, and you start going into that zone three, zone four, where you're using glucose and producing lactate as a byproduct, your body's going, oh, I need to...

I need to increase my mitochondrial density so that I can start using my mitochondria, right?

It's an adaptation.

It's a response to that stressor.