Robert Fried

Researchers were investigating fermentation in yeast, and they realized that there was this coenzyme that was involved in the energy metabolism process.

Then in like the 1930s, there was this outbreak of a condition called progeria.

And they found out that they could cure this disease with the vitamin B3.

And that vitamin B3 elevated NAD.

And by elevating NAD, they were able to cure progeria.

And B3 is niacin, right?

Yeah.

So niacin increases NAD.

There are several molecules that increase NAD.

Nicotinamide riboside or Niagen is not the only one.

It just happens to be the best one.

But it's not the only one.

There are other ways to elevate NAD.

Then in the 1950s, it was discovered that NAD was central to this Krebs cycle, the citric acid cycle, the process of actually making energy.

within the cell.

And actually, the Nobel Prize winner who discovered that is the father of one of our current scientific advisors, Roger Kornberg.

It was Arthur Kornberg.

Roger also was a Nobel Prize winner in chemistry at Stanford.

And then in 2003, Charles Brenner, who you've had on twice, had this incredible discovery that nicotinamide riboside, which is found in trace amounts in milk,

not only more efficiently elevates NAD levels in the cell than anything else we've seen, more than niacin, more than anything else, and not only extremely safely, but it does something else fairly remarkable, which is when a cell is under specific metabolic stress, it opens up a pathway that he named the NR kinase pathway, calling out for whatever trace amounts of NR are floating through the bloodstream.