Robin Carhart-Harris

They could have gone off to Oregon to have legal adult supervised psilocybin experiences.

We've looked at that too.

But, you know, across those different contexts, when we pull the data, very positive results there as well.

So yeah, so most people is the short answer, seem to benefit, but not everyone.

So then the critical question is, where is this bottom margin?

You know, who falls into that?

Who's at special risk?

Who's at risk of being, you know,

in that outlier bracket where they don't improve and if if anything they get worse where could this be iatrogenic you know as as they say meaning it actually worsens your health

And there we have found empirically that people with a history of a diagnosis, I'm being very concrete here, but history of a diagnosis of a personality disorder.

And what is that?

Well, it's an emotional volatility can come in different forms, but it can be a sort of

histrionic character presentation, very volatile, very splitty, as we would say in psychology, meaning jumping from positive projection, everything is good, or this person is all good, entirely flawless, to this one is all bad and entirely malevolent, quite irrational.

But people do that.

They make the world black and white.

And that kind of psychological volatility is a risk factor.

We actually found that people with that history were four times more likely to fall into a bottom margin in our grouped data.

So they were the worst cases.

Another bit of detail, that group actually did okay numerically, a very slight improvement in well-being in the short period after the experience.

But then they fell off a cliff, so to speak.