Sam Fazeli

Looking also at Destiny Bristol 9, Destiny Bristol 3, it begins to cover a whole population almost of the patients.

So do you want to tell us what we learned from DB11, just to shorten it, and what it means first for the DB11 and what it means for patients?

Now, these are patients, as you rightly say, that are being treated with curative intent.

Given that, how long do you think we'd have to wait to see if there's an impact on overall survival?

You did say that pathologic complete response, which just to be clear, is when you take tumors out and have a look at them and you find no viable cells.

There might be tumor there, but...

or at least a mass there, but no viable cells or very few.

How long would it take before we see whether there is a major or meaningful impact on survival here, which of course has to be the end game, right?

Okay, now just back to, we'll come to Destiny Breast05 in a minute, but in DB11, you did say, and I think you explained very clearly at the analyst meeting that I think is freely available on your website for folks to listen to if they needed to, that although the comparator arm was a standard of care,

It's not the only standard of care.

And I think the explanation was also given that, don't forget, this trial was started even before COVID, right?

And then you ended up in a situation where you, you know, so over time, of course, when you do these long trials, there is a potential for change in standard of care.

How would we read that in terms of how sure are you if physicians wanted to use this with another standard

combo, that they would get similar results?

Or do you think there would have to be done, further trials have to be done?

Okay, and then one last question on DB11 before we move on to DB05, and that is the ILD pneumonitis rates.

ILD is one of the side effects of N HER2 and other HER2-targeting ADCs and even some other ADCs, I think.

So, but you represented them as a combination.

Now, ILD is a, if I'm not wrong, and you can correct me if I am wrong, is a relatively, has a risk of long-term consequences, whereas pneumonitis is maybe viewed as a more short-term issue.

Was there much of a difference between the two?