Saranya Wyles, M.D., Ph.D.

If you get a wound, if you get an injury, that scaffold is what brings everything back together.

So certain signaling peptides that can promote pro-collagen and pro-elastin.

So those are the ones that we could be looking for, like pomatil pentapeptide 4.

That one was recently described to have good penetration into the skin barrier.

So it's

So yeah, so I think overall, there's a lot of excitement within the peptide space and even a lot of companies talking about combination of peptides.

And I think that's where we're headed.

So we really need to be looking at there's not one peptide that's going to sing the song of victory.

Like you need to have a combination.

Yeah, so I think my top three would be the pomatil pentapeptide 4.

So this was just described and trademarked as Matrixyl.

So this can increase collagen 1, which we really want.

And they'd shown up to...

200% increase in collagen, one in in vitro studies.

So when it comes down to in vivo and topical application, it's going to be a lot less than that, but that's a really encouraging number for translating in vitro to human skin.

So I would put that in the top.

Copper peptide is great.

It's kind of helped and shown support for collagen elastin, glycosaminoglycans.

We've been talking about copper tripeptide for a long time.

So it also has a lot of antioxidant