Saranya Wyles, M.D., Ph.D.

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The mindbodygreen Podcast · 632: The science of skin aging & how to slow it down | Saranya Wyles, M.D., Ph.D. · 11 Jan 2026 podcast

Lasers induce a controlled thermal injury.

So they're like little micro columns of thermal heat injury that can then activate fibroblasts.

They can then produce collagen.

and elastin and healthy blood vessel formulation called androgenesis.

So lasers are a dose-controlled way to stimulate these exact pathways that decline with age.

And we recently did a study looking at patients before and after

an ablative laser and looking to see how they influence the senescent cells pathways.

And what we show is that when you have a fractional CO2 or erbium laser, this can actually reduce your P16 senescent cells and restore a healthier fibroblast function.

So they're actually helping to reset the skin function and kind of clear out the weeds of the senescent cells, if you will.

So really, I think lasers are underestimated in this way to reset the skin and kind of create like healthier skin turnover.

So there's a lot of different types of lasers.

You could do a laser that has low downtime.

So for some patients, downtime is really important to consider.

They are not able to afford a week or two of taking time off and having a long recovery period.

So yeah.

If patients just have a shorter recovery period time, you can have them come in for a monthly laser, kind of a low energy type of laser that you could be doing once every three months or once a month where picogenesis is a laser that I commonly use in my practice.

And we call it the lunchtime laser because it's super low downtime and people can come in and kind of get a

get a quick re-energy or reset of their skin and then kind of follow up over time.

Or you can do more non-ablative lasers twice a year.

They do have about a three to five day downtime depending on the laser type.

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