Saranya Wyles, M.D., Ph.D.

how they're procuring their practices.

But the products itself, they have really good science behind them of retaining skin structure over time.

I think we have entered a very exciting time in science and medicine where we're meeting artificial intelligence and advancements in innovation that's really opening doors in a big way.

At Mayo Clinic, we've launched a registry called SALUD, S-A-L-U-D, it stands for Skin Aging and Longevity Understanding Database.

We are looking to profile 500 patients

across three to five years, the same patient over time through a lot of different biomarkers.

So looking at systemic health, your heart ECG, your heart function and cognitive function, and looking at specific biomarkers like your buccal swabs we take, your skin tape stripping, your microbiome.

We're looking at skin biopsies, blood, urine samples, peripheral vascular imaging.

all this really rich data set over time, over five years.

This is the first time we're going to be able to understand how one person ages over time and then look at it across different populations and couple that with our ability to automate this data

and utilize artificial intelligence to understand and make these different connections.

I think this is really going to change the level of what we know for what is aging at the level of the skin.

We're doing some very advanced spatial sequencing.

It's called spatial transcriptomics, spatial proteomics, and these sound really fancy, but what it actually is is mapping out tens and thousands of cells

at the same time and how they correlate and what signals are coming from them.

So think about it as before we used to know, I'm in Minnesota, so I'm going to talk about Rochester, Minnesota.

Before we used to know just what's happening in Rochester, Minnesota, and now with these spatial omics data, we can look at what's happening in the entire world.

and to look at and map at all these different pathways.

So I think we're just entering this really data-rich era right now, and we can couple that to technologies like 3D bioprinting.

So one of the things that we're doing in our lab is bioprinting to your skin blueprint.