Saranya Wyles, M.D., Ph.D.

So we could actually take, Jason, your skin cells and

do an omics profile and create like an architectural blueprint of where your skin is, where are your senescent cells, where are your melanocytes, your fibroblasts, and then superimpose that into a CAD drawing.

So this is basically how you can, you know, build the blueprint of the skin and then have our 3D printers with melanocytes, fibroblasts, keratinocytes, all specific bio-inks and print these skin layers to match your specific skin profile.

Exactly.

Exactly.

Exactly.

That's our ultimate goal is to see how we can biohack from the level of the skin, right, in a very tangible, scientifically validated way.

By having all this data, this is going to inform the science of how skin and systemic aging are connected.

We're actually working closely with the NIH National Institute on Aging on a project on the largest study on aging called the Baltimore Longitudinal Study on Aging.

It was started in the 1950s and they've collected skin samples.

So we've partnered with them to look at these skin samples and then profile it with their systemic factors, like their neurocognitive aging and their heart health, and then see how the skin and systemic health are interconnected and see what we can learn from that.

So we're at the tip of the iceberg.

It's really, really exciting.

What we're finding is that there is a correlation with senescence in the skin and senescence burden in the skin affects neurocognitive function.

And we actually published this work in a mice model in aging cell in last year.

And what we found was when we artificially introduced senescent cells in these young mice at the level of their skin, and then we looked at different cognitive function,

they started to decline in their cognitive function.

And they also had increases in senescence-associated markers in their hippocampus.

So just by localizing senescence in the skin, you're actually creating end-organ damage at the level of the brain.

Yeah, we can turn down the noise from zombie cells, right?