Tim Friede
๐ค SpeakerAppearances Over Time
Podcast Appearances
So he found his way to Tim and called him up. Tim remembers Jacob saying to him, You're the guy I'm looking for.
So he found his way to Tim and called him up. Tim remembers Jacob saying to him, You're the guy I'm looking for.
So he found his way to Tim and called him up. Tim remembers Jacob saying to him, You're the guy I'm looking for.
We need your blood. We need your antibodies. I'm like... Wow. Cool. Great.
We need your blood. We need your antibodies. I'm like... Wow. Cool. Great.
We need your blood. We need your antibodies. I'm like... Wow. Cool. Great.
Well, once Tim agreed to participate, Jacob got a blood sample from him and he scanned it for its immune memory. He searched the troves of antibodies for those that neutralize the neurotoxins of multiple snakes.
Well, once Tim agreed to participate, Jacob got a blood sample from him and he scanned it for its immune memory. He searched the troves of antibodies for those that neutralize the neurotoxins of multiple snakes.
Well, once Tim agreed to participate, Jacob got a blood sample from him and he scanned it for its immune memory. He searched the troves of antibodies for those that neutralize the neurotoxins of multiple snakes.
The antibody, which has a name that's just a string of letters and numbers like a license plate, gave mice full protection against five snakes, the black mamba, and a mix of cobras. So Jacob and his colleagues wrote the journal Cell to gauge their interest in publishing the research. One of those colleagues was Peter Kwong, a structural biologist at Columbia University.
The antibody, which has a name that's just a string of letters and numbers like a license plate, gave mice full protection against five snakes, the black mamba, and a mix of cobras. So Jacob and his colleagues wrote the journal Cell to gauge their interest in publishing the research. One of those colleagues was Peter Kwong, a structural biologist at Columbia University.
The antibody, which has a name that's just a string of letters and numbers like a license plate, gave mice full protection against five snakes, the black mamba, and a mix of cobras. So Jacob and his colleagues wrote the journal Cell to gauge their interest in publishing the research. One of those colleagues was Peter Kwong, a structural biologist at Columbia University.
Yes, one that would take on even more snakes. This is so cool. The team agreed it was worth a try. First, they added a small synthetic molecule, one that had already been shown to work against some venoms. Here's Jacob again.
Yes, one that would take on even more snakes. This is so cool. The team agreed it was worth a try. First, they added a small synthetic molecule, one that had already been shown to work against some venoms. Here's Jacob again.
Yes, one that would take on even more snakes. This is so cool. The team agreed it was worth a try. First, they added a small synthetic molecule, one that had already been shown to work against some venoms. Here's Jacob again.
The team also went back to Tim's blood and found a second broad-acting antibody.
The team also went back to Tim's blood and found a second broad-acting antibody.
The team also went back to Tim's blood and found a second broad-acting antibody.
This cocktail of three components offered mice complete protection against 13 species and partial protection against six more, representing a set of genetically diverse venomous snakes from Asia, Africa, Australia, North America, and more.
This cocktail of three components offered mice complete protection against 13 species and partial protection against six more, representing a set of genetically diverse venomous snakes from Asia, Africa, Australia, North America, and more.