Wendy Zuckerman
speaker
3,034 appearances
14 recordings
3 series
first heard May 2020
last heard 2 Jul
Wendy Zuckerman’s voice in public audio — every appearance, attributed to the second.
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recordings per month · last 12 monthsRecordings per month over the last 12 months — 10 in all, peaking in Jun 2026 with 3.
Appearances
So, when Hassi's team first discovered this little peptide, just 16 amino acids all strung together,
And one of the things that they did is put some mice on a high-fat diet, which would usually make them put on weight.
Then they injected some MOTC into them.
Whoa!
Fat in the liver can be dangerous.
It can muck up the liver itself, but it can also lead to things like stroke.
So the idea that this peptide could prevent that from happening, even when the mice were eating all these calories...
That was potentially big.
The team kept testing it.
They gave older mice MOTC and they lived longer than mice on a placebo.
Hassi's team worked out that MOTC might protect muscle by blocking the activity of a molecule that can break down muscle.
One study found that in men, having a mutated form of MOTC increased their risk of type 2 diabetes and having more visceral fat.
Another study found that type 2 diabetics with low MOTC had a higher risk of having a life-threatening cardiac event.
Hassi thought, this MOTC, there really could be something here.
So he started a company with a friend and they raised $80 million and ran a small clinical trial of MOTC.
They got people with a high BMI and quite a bit of fat around their liver, had them come into a lab.
The people were injected with either MOTC or a placebo.
And Hussey basically wanted to know, would those getting MOTC lose more weight?
Would they lose some of the fat around their liver?
And here's what happened.
Showing 1081–1100 of 3,034 · page 55 of 152
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