100NO 649: Is Ozempic the Ultimate Biohack?

Today we dive into the “wonder drug” Ozempic and its prominence in the conversation around weight loss, longevity, and biohacking. With Ozempic making headlines as a modern-day solution for weight management, we discuss what it is, how it works, its risks and side effects, and where it fits into the wider discussion of sustainable health and lifestyle change. **Key Topics:** – **How Ozempic Works:**     Damo explains Ozempic’s primary functions: – **Philosophy & Practicality of Pharmaceutical Interventions:**     The conversation addresses when pharmaceutical options become appropriate, such as when lifestyle modifications haven’t worked or when someone is in an urgent health situation. – **Biohacking & Longevity Claims:**     – We look at recent claims about Ozempic’s potential to “reverse biological aging by 3.1 years,” discussing scientific skepticism and comparisons to drugs like Metformin and therapies like stem cells.   – We discuss our concerns over the methodology and implications of “biological age” metrics. – **Risks & Side Effects:**     Common and serious side effects mentioned:   – Nausea, vomiting, constipation, abdominal pain   – Appetite suppression due to delayed gastric emptying   – Gallbladder problems, fatigue, muscle loss, potential thyroid tumors     *Muscle loss is highlighted as the most significant concern for healthy aging.* – **Lifestyle Change vs. Medical Intervention:**     Damo discusses the “second-last resort” of real, sustained lifestyle and dietary change before resorting to pharmaceutical interventions. The reality, challenges, and sustainability of lifestyle changes are explored. **Memorable Quotes:** – “Ideally, people would make a decision about their health and wellbeing long before pharmaceutical intervention is required.” – Dr. Damian Kristof – “It’s taking all the fun out of this thing called food.” – Marcus Pearce For more on Damo go to www.damiankristof.com For more on Marcus go to www.marcuspearce.com.au For more on 100 Not Out go to www.100notout.com

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