Dr. Alessio Fasano: Exploring Coeliac Disease, Zonulin & the Microbiome

A Gluten Free Podcast Episode 67 I’m incredibly honoured to welcome Dr. Alessio Fasano, MD, world-renowned paediatric gastroenterologist and the visionary founder of the Center for Celiac Research, to today’s episode of A Gluten Free Podcast. Dr. Fasano is one of the most influential figures in the field of coeliac disease research, having pioneered groundbreaking work that has transformed our understanding of this complex autoimmune condition.In this in-depth conversation, we dive into what initially inspired Dr. Fasano to dedicate his career to studying coeliac disease and the gluten free diet. We discuss his discovery of zonulin, a key protein that regulates intestinal permeability — often referred to as the “leaky gut” — and its profound implications not only for coeliac disease but also for a wide range of autoimmune and inflammatory disorders.We also explore the exciting and rapidly evolving field of the microbiome and how the trillions of microbes living in our gut interact with genetic and environmental factors to influence the development and management of coeliac disease.Whether you’re newly diagnosed, a seasoned gluten free advocate, or simply interested in the science behind gut health, this episode offers invaluable insights straight from a leading expert pushing the boundaries of research.In this episode, we’ll cover:Dr. Fasano’s journey: What inspired him to begin researching coeliac disease, including the personal and scientific motivations that have driven his workThe mission, vision, and key research initiatives at the Center for Celiac Research, including ongoing projects and clinical trialsAn introduction to zonulin — what it is, how it functions, and why it’s a critical factor in intestinal barrier regulation and the development of coeliac diseaseUnderstanding the concept of the “leaky gut” and its broader role in autoimmune diseases and gut healthThe role of the gut microbiome — how the balance of bacteria in our digestive system influences coeliac disease symptoms, immune response, and overall wellbeingHow advancements in this research are shaping future diagnostic tools, treatment approaches, and potential therapies for coeliac disease and related conditionsWhy this episode matters:Dr. Alessio Fasano’s pioneering work has changed how the medical community understands coeliac disease — moving from a condition defined solely by gluten avoidance to a complex interplay of genetics, intestinal biology, and environmental factors. His research into zonulin and the microbiome opens new pathways for improving diagnosis, patient care, and quality of life.For anyone living with coeliac disease, caregivers, or healthcare professionals, this episode provides a unique opportunity to hear directly from a leader whose discoveries continue to shape the future of gluten related disorders.Links & Resources:Head to happytummies.com.au & use our code GFCHRISTMAS to save 20% off Free From Family Co everyday range! Valid from 8th Nov - 25th December, 2025.  Up to 25% discounts on Bask & Co products site-wide and with NO discount codes required! FREE shipping on orders over $99. Only while stocks last! Shop here🥣 Celiac Cruise - a 100% gluten free vacation cruise is setting sail on two Australian cruises in 2026: one to the South Pacific and the other to New Zealand. There'll of course be awesome 100% gluten free food onboard, heaps of fun stuff to do, educational talks and a community of people who understand each other. Buy your tickets here & see ya onboard gluten free fam! 

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