AI + a16z
Episodes
OpenClaw: Why the Internet Isn't Built for AI Agents
19 Mar 2026
Contributed by Lukas
Yoko Li, Guido Appenzeller, and Joel de la Garza discuss OpenClaw, the open source personal AI assistant that's forcing a rethink of how identity, per...
What's Missing Between LLMs and AGI - Vishal Misra & Martin Casado
17 Mar 2026
Contributed by Lukas
Vishal Misra returns to explain his latest research on how LLMs actually work under the hood. He walks through experiments showing that transformers u...
Replit's CEO on Vibe Coding, Wealth Building, and What Most People Get Wrong About AI
10 Mar 2026
Contributed by Lukas
Jack Neel speaks with Amjad Masad, CEO at Replit, about how AI is making it easier than ever to build and ship software without a technical background...
Jack Altman & Martin Casado on the Future of VC
03 Mar 2026
Contributed by Lukas
Jack Altman sits down with Martin Casado, General Partner at a16z, to unpack the shifting dynamics of venture capital and why media matters more than ...
AI’s Capital Flywheel: Models, Money, and the Future of Power
24 Feb 2026
Contributed by Lukas
a16z's Martin Casado and Sarah Wang join Latent Space hosts Alessio Fanelli and Swyx to discuss what makes this AI investment cycle unlike anything in...
Durable Execution and the Infrastructure Powering AI Agents
19 Feb 2026
Contributed by Lukas
Sarah Wang, general partner at a16z, and Raghu Raghuram, managing partner at a16z, speak with Samar Abbas, CEO of Temporal, about how durable executio...
Evals, Feedback Loops, and the Engineering That Makes AI Work
17 Feb 2026
Contributed by Lukas
Martin Casado speaks with Ankur Goyal, founder and CEO of Braintrust, about where engineering actually matters in AI and where it doesn't. They cover ...
Sam Altman on Sora, Energy, and Building an AI Empire
10 Feb 2026
Contributed by Lukas
Sam Altman has led OpenAI from its founding as a research nonprofit in 2015 to becoming the most valuable startup in the world ten years later.In this...
Why This Isn't the Dot-Com Bubble | Martin Casado on WSJ's BOLD NAMES
03 Feb 2026
Contributed by Lukas
Christopher Mims and Tim Higgins of the Wall Street Journal sit down with a16z General Partner Martin Casado on WSJ’s Bold Names to ask whether the ...
Martin Casado on the Demand Forces Behind AI
27 Jan 2026
Contributed by Lukas
In this feed drop from The Six Five Pod, a16z General Partner Martin Casado discusses how AI is changing infrastructure, software, and enterprise purc...
How Mintlify Is Rebuilding Documentation for Coding Agents
23 Jan 2026
Contributed by Lukas
Mintlify is a documentation platform built by cofounders Han Wang and Hahnbee Lee to help teams create and maintain developer docs. In this episode, A...
Inferact: Building the Infrastructure That Runs Modern AI
22 Jan 2026
Contributed by Lukas
Inferact is a new AI infrastructure company founded by the creators and core maintainers of vLLM. Its mission is to build a universal, open-source inf...
How Should AI Be Regulated? Use vs. Development
20 Jan 2026
Contributed by Lukas
To Regulate AI Effectively, Focus on How It’s UsedA conversation with Martin Casado on learning from past computing platform shifts, understanding m...
Michael Truell: How Cursor Builds at the Speed of AI
13 Jan 2026
Contributed by Lukas
When four MIT grads decided to build a code editor while everyone else was building AI agents, they created the fastest-growing developer tool ever bu...
Dylan Patel on the AI Chip Race - NVIDIA, Intel & the US Government
06 Jan 2026
Contributed by Lukas
Nvidia’s $5 billion investment in Intel is one of the biggest surprises in semiconductors in years. Two longtime rivals are now teaming up, and the ...
Feed Drop from The Generalist: Why a16z's Martin Casado believes the AI boom still has years to run
30 Dec 2025
Contributed by Lukas
This episode is a special replay from The Generalist Podcast, featuring a conversation with a16z General Partner Martin Casado. Martin has lived throu...
Fei-Fei Li: World Models and the Multiverse
23 Dec 2025
Contributed by Lukas
What if the next leap in artificial intelligence isn’t about better language—but better understanding of space?In this episode, a16z General Partn...
Building the “See Something, Say Something” AI for Every Camera
16 Dec 2025
Contributed by Lukas
a16z's Martin Casado sits down with Shikhar Shrestha, CEO and cofounder of Ambient, the company bringing agentic AI to physical security.Shikhar share...
The AI That Found A Bug In The World’s Most Audited Code
10 Dec 2025
Contributed by Lukas
Matt Knight spent five years as OpenAI’s CISO. Now he runs what colleagues call “the most interesting job at the company”: leading Aardvark, an ...
The Death of Data Gatekeeping: AI Makes Everyone An Analyst | Hex Cofounder
05 Dec 2025
Contributed by Lukas
Most companies still rely on dashboards to understand their data, even though AI now offers new ways to ask questions and explore information. Barry M...
Why Social Engineering Now Works on Machines
02 Dec 2025
Contributed by Lukas
Ian Webster built PromptFoo after watching 200 million Discord users systematically dismantle his AI agent—now Fortune 10 companies pay him to break...
“Anyone Can Code Now” - Netlify CEO Talks AI Agents
28 Nov 2025
Contributed by Lukas
Netlify's CEO, Matt Biilmann, reveals a seismic shift nobody saw coming: 16,000 daily signups—five times last year's rate—and 96% aren't coming fr...
From Code Search to AI Agents: Inside Sourcegraph's Transformation with CTO Beyang Liu
25 Nov 2025
Contributed by Lukas
Sourcegraph's CTO just revealed why 90% of his code now comes from agents—and why the Chinese models powering America's AI future should terrify Was...
Ryo Lu (Cursor): AI Turns Designers to Developers
21 Nov 2025
Contributed by Lukas
Ryo Lu spent years watching his designs die in meetings. Then he discovered the tool that lets designers ship code at the speed of thought: Cursor, th...
How Foundation Models Evolved: A PhD Journey Through AI's Breakthrough Era
18 Nov 2025
Contributed by Lukas
The Stanford PhD who built DSPy thought he was just creating better prompts—until he realized he'd accidentally invented a new paradigm that makes L...
TruffleHog Creator: You Can’t Have AI Agents Without Secrets
11 Nov 2025
Contributed by Lukas
If you can’t robustly protect your secrets, you can’t have reliable AI agents.In this episode, Truffle Security cofounder and CEO Dylan Ayrey join...
Tigris Data CEO on Building Your Own Datacenters
07 Nov 2025
Contributed by Lukas
In this episode, a16z General Partner Martin Casado sits down with Ovais Tariq, Cofounder and CEO of Tigris Data, to discuss why independent storage i...
Pylon: Reimagining B2B Customer Support
31 Oct 2025
Contributed by Lukas
Customer support platforms lacked adequate solutions for B2B companies - until Pylon entered the scene.We sat down with Pylon cofounders Marty Kausas,...
Keycard: 2026 is the Year of Agents
22 Oct 2025
Contributed by Lukas
In 2025, we saw the first glimpses of true AI agents. In 2026, every company will be rushing to get them into production, and they’ll need companies...
The Trillion Dollar AI Software Development Stack
10 Oct 2025
Contributed by Lukas
AI coding has emerged as a major market for AI: one that’s already rewriting how software gets built.a16z Infra Partners Yoko Li and Guido Appenzell...
Material Security CEO: How To Find Your Ideal Customer
06 Oct 2025
Contributed by Lukas
What if the hardest part of building a company isn’t the product, but knowing exactly who it’s for?In this episode, a16z General Partner Martin Ca...
When Deepfakes Steal $30M: The New Edge of Cybercrime
26 Sep 2025
Contributed by Lukas
AI is transforming both sides of the cybersecurity cat-and-mouse game. Attackers are using LLMs to scale impersonation, phishing, and even deepfake fr...
How AI Will Change Photography Forever
17 Sep 2025
Contributed by Lukas
What if you could retake your favorite memories years after they happened, fixing the lighting, catching the smile, or even opening your eyes?In this ...
How OpenAI Built Its Coding Agent
29 Aug 2025
Contributed by Lukas
OpenAI’s Codex has already shipped hundreds of thousands of pull requests in its first month. But what is it really, and how will coding agents chan...
Models, Modalities, and Memes: Creating Compelling AI Characters
14 Aug 2025
Contributed by Lukas
Models, Modalities, and Memes: Creating Compelling AI CharactersIn this episode of AI + a16z, Hedra founder and CEO Michael Lingelbach joins a16z part...
Performance and Passion: Fal's Approach to AI Inference
01 Aug 2025
Contributed by Lukas
If you've been experimenting with image, video, and audio models, the chances are you've been both blown away by how good they're becoming, and also a...
How to Vibe Code Securely
25 Jul 2025
Contributed by Lukas
In this episode, a16z partner Joel de la Garza sits down with Socket founder and CEO Feross Aboukhadijeh to dive into the intersection of vibe coding ...
AI Is Upending SaaS Pricing
18 Jul 2025
Contributed by Lukas
In this episode, a16z GP Martin Casado sits down with Metronome CEO Scott Woody to unpack how AI is fundamentally changing the value proposition of so...
The AI Infrastructure Stack with Jennifer Li
11 Jul 2025
Contributed by Lukas
In this episode, which originally aired on the Complex Systems Podcast, a16z General Partner Jennifer Li discusses how AI is reshaping every layer of ...
AI's Unsung Hero: Data Labeling and Expert Evals
27 Jun 2025
Contributed by Lukas
Labelbox CEO Manu Sharma joins a16z Infra partner Matt Bornstein to explore the evolution of data labeling and evaluation in AI — from early supervi...
AI, Data Engineering, and the Modern Data Stack
20 Jun 2025
Contributed by Lukas
In this episode of AI + a16z, dbt Labs founder and CEO Tristan Handy sits down with a16z's Jennifer Li and Matt Bornstein to explore the next chapter ...
Enabling Agents and Battling Bots on an AI-Centric Web
13 Jun 2025
Contributed by Lukas
Arcjet CEO David Mytton sits down with a16z partner Joel de la Garza to discuss the increasing complexity of managing who can access websites, and oth...
Giving New Life to Unstructured Data with LLMs and Agents
06 Jun 2025
Contributed by Lukas
Instabase founder and CEO Anant Bhardwaj joins a16z Infra partner Guido Appenzeller to discuss the revolutionary impact of LLMs on analyzing unstructu...
Beyond Leaderboards: LMArena’s Mission to Make AI Reliable
30 May 2025
Contributed by Lukas
LMArena cofounders Anastasios N. Angelopoulos, Wei-Lin Chiang, and Ion Stoica sit down with a16z general partner Anjney Midha to talk about the future...
Building AI Systems You Can Trust
23 May 2025
Contributed by Lukas
In this episode of AI + a16z, Distributional cofounder and CEO Scott Clark, and a16z partner Matt Bornstein, explore why building trust in AI systems ...
Who's Coding Now? AI and the Future of Software Development
16 May 2025
Contributed by Lukas
In this episode of the a16z AI podcast, a16z Infra partners Guido Appenzeller, Matt Bornstein, and Yoko Li explore how generative AI is reshaping soft...
MCP Co-Creator on the Next Wave of LLM Innovation
02 May 2025
Contributed by Lukas
In this episode of AI + a16z, Anthropic's David Soria Parra — who created MCP (Model Context Protocol) along with Justin Spahr-Summers — sits dow...
What Is an AI Agent?
28 Apr 2025
Contributed by Lukas
In this episode of AI + a16z, a16z Infra partners Guido Appenzeller, Matt Bornstein, and Yoko Li discuss and debate one of the tech industry's buzzies...
Benchmarking AI Agents on Full-Stack Coding
28 Mar 2025
Contributed by Lukas
In this episode, a16z General Partner Martin Casado sits down with Sujay Jayakar, co-founder and Chief Scientist at Convex, to talk about his team’s...
Automating Developer Email with MCP and Al Agents
21 Mar 2025
Contributed by Lukas
In this episode of AI + a16z, Resend founder and CEO Zeno Rocha sits down with a16z partner Yoko Li to discuss:How generative AI — powered by agen...
The Future of Digital Workers
20 Mar 2025
Contributed by Lukas
In this episode of AI + a16z, a16z Partner Joe Schmidt sits down with 11x CTO Prabhav Jain for an inside look at how AI-powered digital workers are re...
Building the Next Generation of Conversational AI
14 Mar 2025
Contributed by Lukas
In this episode of AI + a16z, Sesame Cofounder and CTO Ankit Kumar joins a16z general partner Anjney Midha for a deep dive into the research and engin...
Agent Experience: Building an Open Web for the AI Era
07 Mar 2025
Contributed by Lukas
In this episode of AI + a16z, Netlify CEO and Cofounder Matt Biilmann joins a16z General Partner Martin Casado to explore how AI is reshaping web deve...
What DeepSeek Means for Cybersecurity
28 Feb 2025
Contributed by Lukas
In this episode of AI + a16z, a trio of security experts join a16z partner Joel de la Garza to discuss the security implications of the DeepSeek reaso...
Agents, Lawyers, and LLMs
21 Feb 2025
Contributed by Lukas
In this episode of AI + a16z, Aatish Nayak, head of product at Harvey, sits down with a16z partner Kimberly Tan to share his experience building AI pr...
Reasoning Models Are Remaking Professional Services
14 Feb 2025
Contributed by Lukas
In this episode of AI + a16z, a16z partner Alex Immerman sits down with Hebbia founder and CEO George Sivulka to discuss the potential for reasoning m...
Data Management for Enterprise LLMs
07 Feb 2025
Contributed by Lukas
In this episode of AI + a16z, Fivetran cofounder and CEO George Fraser and a16z partner Guido Appenzeller discuss how LLMs fit into the data managemen...
From NLP to LLMs: The Quest for a Reliable Chatbot
10 Jan 2025
Contributed by Lukas
In this episode of AI + a16z, a16z General Partner Martin Casado and Rasa cofounder and CEO Alan Nichol discuss the past, present, and future of AI ag...
Best of the Year: Building AI Companies
27 Dec 2024
Contributed by Lukas
A 2024 highlight reel, featuring founders sharing their insights, advice, and experiences building AI companies — from foundation-model labs to vert...
Can AI Agents Finally Fix Customer Support?
18 Dec 2024
Contributed by Lukas
In this episode of the AI + a16z podcast, Decagon cofounder/CEO Jesse Zhang and a16z partner Kimberly Tan discuss how LLMs are reshaping customer supp...
REPLAY: Scoping the Enterprise LLM Market
30 Nov 2024
Contributed by Lukas
This is a replay of our first episode from April 12, featuring Databricks VP of AI Naveen Rao and a16z partner Matt Bornstein discussing enterprise LL...
Building Developers Tools, From Docker to Diffusion Models
15 Nov 2024
Contributed by Lukas
In this episode of AI + a16z, Replicate cofounder and CEO Ben Firshman, and a16z partner Matt Bornstein, discuss the art of building products and comp...
The Best Way to Achieve AGI Is to Invent It
04 Nov 2024
Contributed by Lukas
Longtime machine-learning researcher, and University of Washington Professor Emeritus, Pedro Domingos joins a16z General Partner Martin Casado to disc...
Neural Nets and Nobel Prizes: AI's 40-Year Journey from the Lab to Ubiquity
25 Oct 2024
Contributed by Lukas
In this episode of AI + a16z, General Partner Anjney Midha shares his perspective on the recent collection of Nobel Prizes awarded to AI researchers i...
How GPU Access Helps AI Startups Be Agile
23 Oct 2024
Contributed by Lukas
In this episode of AI + a16z, General Partner Anjney Midha explains the forces that lead to GPU shortages and price spikes, and how the firm mitigates...
DisTrO and the Quest for Community-Trained AI Models
27 Sep 2024
Contributed by Lukas
In this episode of AI + a16z, Bowen Peng and Jeffrey Quesnelle of Nous Research join a16z General Partner Anjney Midha to discuss their mission to kee...
Balancing AI Expertise and Industry Acumen in Vertical Applications
13 Sep 2024
Contributed by Lukas
In this episode of AI + a16z, Ambience cofounder and chief scientist Nikhil Buduma joins Derrick Harris to discuss the nuances of using AI models to b...
AI, SQL, and the End of Big Data
30 Aug 2024
Contributed by Lukas
In this episode of AI + a16z, a16z General Partner Jennifer Li joins MotherDuck Cofounder and CEO Jordan Tigani to discuss DuckDB's spiking popularity...
The Researcher to Founder Journey, and the Power of Open Models
16 Aug 2024
Contributed by Lukas
In this episode of the AI + a16z podcast, Black Forest Labs founders Robin Rombach, Andreas Blattmann, and Patrick Esser sit down with a16z general pa...
Why Computer Science Subsumed Biotech
09 Aug 2024
Contributed by Lukas
In this episode, a16z General Partner Vijay Pande walks us through the past two decades of applying software engineering to the life sciences — from...
Democratizing Generative AI Red Teams
02 Aug 2024
Contributed by Lukas
In this episode of the AI + a16z podcast, a16z General Partner Anjney Midha speaks with PromptFoo founder and CEO Ian Webster about the importance of ...
Augmenting Incident Response with LLMs
26 Jul 2024
Contributed by Lukas
In this episode of the AI + a16z podcast, Command Zero cofounder and CTO Dean de Beer joins a16z's Joel de la Garza and Derrick Harris to discuss the ...
Scaling AI for the Coming Data Deluge
19 Jul 2024
Contributed by Lukas
In this episode of the AI + a16z podcast, Anyscale cofounder and CEO Robert Nishihara joins a16z's Jennifer Li and Derrick Harris to discuss the chall...
ARCHIVE: The Dream of AI Is Alive in AlphaGo
05 Jul 2024
Contributed by Lukas
In this archive episode from 2015, a16z's Sonal Chokshi, Frank Chen, and Steven Sinofsky discuss DeepMind's breakthrough AlphaGo system, which mastere...
Beyond Language: Inside a Hundred-Trillion-Token Video Model
03 Jul 2024
Contributed by Lukas
In this episode of the AI + a16z podcast, Luma Chief Scientist Jiaming Song joins a16z General Partner Anjney MIdha to discuss Jiaming's esteemed care...
Developer Tool UX in the Age of Generative AI
21 Jun 2024
Contributed by Lukas
In this episode, design engineer Alasdair Monk joins a16z's Yoko Li and Derrick Harris to discuss how generative AI is changing how developers — and...
Building Production Workflows for AI Applications
14 Jun 2024
Contributed by Lukas
In this episode, Inngest cofounder and CEO Tony Holdstock-Brown joins a16z partner Yoko Li, as well as Derrick Harris, to discuss the reality and comp...
The Future of Image Models Is Multimodal
07 Jun 2024
Contributed by Lukas
In this episode, Ideogram CEO Mohammad Norouzi joins a16z General Partner Jennifer Li, as well as Derrick Harris, to share his story of growing up in ...
ARCHIVE: Open Models (with Arthur Mensch) and Video Models (with Stefano Ermon)
24 May 2024
Contributed by Lukas
For this holiday weekend (in the United States) episode, we've stitched together two archived episodes from the a16z Podcast, both featuring General P...
Open Models and Maturation: Assessing the Generative AI Market
17 May 2024
Contributed by Lukas
a16z partners Guido Appenzeller and Matt Bornstein join Derrick Harris to discuss the state of the generative AI market, about 18 months after it real...
Security Founders Talk Shop About Generative AI
15 May 2024
Contributed by Lukas
In this bonus episode, recorded live at our San Francisco office, security-startup founders Dean De Beer (Command Zero), Kevin Tian (Doppel), and Trav...
How to Think About Foundation Models for Cybersecurity
10 May 2024
Contributed by Lukas
In this episode of the AI + a16z podcast, a16z General Partner Zane Lackey and a16z Partner Joel de la Garza sit down with Derrick Harris to discuss h...
Securing the Software Supply Chain with LLMs
03 May 2024
Contributed by Lukas
Socket Founder and CEO Feross Aboukhadijeh joins a16z's Joel de la Garza and Derrick Harris to discuss the open-source software supply chain. Feross a...
ARCHIVE: GPT-3 Hype
01 May 2024
Contributed by Lukas
In this episode, though, we’re traveling back in time to distant — in AI years, at least — past of 2020. Because amid all the news over the past...
Vector Databases and the Power of RAG
26 Apr 2024
Contributed by Lukas
Pinecone Founder and CEO Edo Liberty joins a16z's Satish Talluri and Derrick Harris to discuss the promises, challenges, and opportunities for vector ...
Remaking the UI for AI
19 Apr 2024
Contributed by Lukas
a16z General Partner Anjney Midha joins the podcast to discuss what's happening with hardware for artificial intelligence. Nvidia might have cornered ...
Making the Most of Open Source in AI
12 Apr 2024
Contributed by Lukas
There are few terms in the world of AI — if any — that invoke more of a reaction than a simple four-letter word: Open. Whether it’s industry deb...
Scoping the Enterprise LLM Market
12 Apr 2024
Contributed by Lukas
Naveen Rao, vice president of generative AI at Databricks, joins a16z's Matt Bornstein and Derrick Harris to discuss enterprise usage of LLMs and gene...
Welcome to the AI + a16z podcast
08 Apr 2024
Contributed by Lukas
The AI + a16z podcast captures our thinking on AI across a broad swath of areas, from the infrastructure that powers today’s foundation models to ho...