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Avelino Kuran - Pimp your brain

Clindamycin

29 Oct 2024

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Antibiotika Repetitorium #14, ClindamycinPD: Hemmung der bakteriellen Proteinsynthese (50S) - bakteriostatischWirkspektrum: Gram-positive Kokken + Anaerober--Staphylococcus aureus--Streptokokken--Peptstreptococcus, Peptococcus, Actinomyces Parasiten: Babesia, Plasmodium falciparum, Toxoplasma gondiiPilze: Pneumocystis jirovecii Wirklücken: -im gram-positiven Enterokokken & Clostridioides difficile,-gram-negativ im AllgemeinenPK: i.v., p.o.-BioV 90%, Proteinbindung 90%-HWZ 2-4h (bei Leberschäden höher)-ZNS-gängig: wenig (3% - für Toxo ausreichend)-Elimination: hepatisch renalNW: GI, Allergie, urogenital- pimp your brain: Cdiff Risiko bei 4xC: Clindamycin, Chinolone, Cephalosporine ab 3.gen, Carbapeneme) Anwendung: -Haut/Weichteil/Knochen bei Penicillin-Allergie-Toxinsynthese-Hemmung (toxic shock durch Strep/Staph)

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