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Avelino Kuran - Pimp your brain

Linezolid

18 Oct 2024

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Antibiotika Repetitorium # 9 LinezolidOrale Bioverfügbarkeit 100%Wirkspektrum: gram positiv, inklusive MRSA, VRE, Streptokokken, Listerien, Nocardien,.. PK: -BioV 100%!-HWZ: 6-8h-30% proteinbindung-30-50% elimination durch dialyse-ZNS-Penetration gut (70%)NW: vor allem bei Langzeittherapie (ab 14d, je länger, desto häufiger/stärker):-Myelosuppression-MAO-Hemmung (Interaktionen mit SSRI,..)-Lactad Azidose-Opticus neuropathie und periphere Neuropathie-selten: hypoglykämien bei diabetikern, schwarzhaarzunge

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