157: Synthetic gametes and the non-identity problem: the babies of tomorrow

️ Episode 157: Synthetic gametes and the non-identity problem: the babies of tomorrow In this episode of PaperCast Base by Base, we explore how synthetic DNA technologies may enable the creation of synthetic gametes and why this possibility forces a rethinking of identity, harm, and responsibility in human reproduction. Study Highlights:The authors argue that while building a full human genome remains infeasible today, engineering haploid genomes for gametes is a nearer-term and more tractable objective, drawing on advances such as synthetic chromosomes in yeast. They analyze how synthetic gametes differ ethically from embryo editing and PGD: instead of altering an existing embryo, they may bring into existence a different individual altogether, shifting the moral lens from person‑affecting harms to impersonal benefits and reproductive autonomy. The paper situates the debate within the “non‑identity problem,” explaining that reducing heritable disease risk via designed gametes can be justified as improving overall outcomes even if no particular future person is directly benefited. The authors further distinguish this approach from coercive eugenics, emphasizing voluntary use to minimize preventable suffering rather than to pursue perfection. Conclusion:Synthetic gametes reframe reproductive genetics from selection and modification to creation, raising urgent but navigable ethical questions about wellbeing, autonomy, and how societies should evaluate bringing a better‑off child into existence. Reference:Villalba A, Räsänen J. 2025. Synthetic gametes and the non-identity problem: the babies of tomorrow. Trends in Genetics. https://doi.org/10.1016/j.tig.2025.08.004 License:This episode is based on an open-access article published under the Creative Commons Attribution 4.0 International License (CC BY 4.0) – https://creativecommons.org/licenses/by/4.0/ Support:If you'd like to support Base by Base, you can make a one-time or monthly donation here: https://basebybase.castos.com/ On PaperCast Base by Base you’ll discover the latest in genomics, functional genomics, structural genomics, and proteomics.

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