Base by Base
Episodes
233: Mechanistic basis of NuA3 recognition and H3K14 acetylation
19 Dec 2025
Contributed by Lukas
️ Episode 233: Mechanistic basis of NuA3 recognition and H3K14 acetylation In this episode of PaperCast Base by Base, we explore Cryo-EM structures...
232: Lamin A/C steers fork restart via H3K9me3 and PARylation
18 Dec 2025
Contributed by Lukas
️Episode 232: Lamin A/C steers fork restart via H3K9me3 and PARylation In this episode of PaperCast Base by Base, we explore Nucleoplasmic Lamin A/C...
231: Transcription start sites as a germline mutational hotspot
17 Dec 2025
Contributed by Lukas
️Episode 231: Transcription start sites as a germline mutational hotspot In this episode of PaperCast Base by Base, we explore This study identifies...
230: MIDEAS Y654S hyperactivates MiDAC in a dominant neurodevelopmental syndrome
17 Dec 2025
Contributed by Lukas
️ Episode 230: MIDEAS Y654S hyperactivates MiDAC in a dominant neurodevelopmental syndrome In this episode of PaperCast Base by Base, we explore A ...
229: Inhibiting PCBP2 condensates in Alzheimer’s
15 Dec 2025
Contributed by Lukas
️ Episode 229: Inhibiting PCBP2 condensates in Alzheimer’s In this episode of PaperCast Base by Base, we explore Elevated PCBP2 forms liquid-like...
228: Two non-competing H3N2 stem antibodies reveal evolving antigenicity
14 Dec 2025
Contributed by Lukas
️ Episode 228: Two non-competing H3N2 stem antibodies reveal evolving antigenicity In this episode of PaperCast Base by Base, we explore Structural ...
227: 1q gain enables rescue of aneuploid hESCs during RPE differentiation
13 Dec 2025
Contributed by Lukas
️ Episode 227: 1q gain enables rescue of aneuploid hESCs during RPE differentiation In this episode of PaperCast Base by Base, we explore This stud...
226: FGF4 protects podocytes in diabetic kidney disease
12 Dec 2025
Contributed by Lukas
️ Episode 226: FGF4 protects podocytes in diabetic kidney disease In this episode of PaperCast Base by Base, we explore This study shows that podoc...
225: VRK-1 and BAF-1 release meiotic chromosomes
10 Dec 2025
Contributed by Lukas
️ Episode 225: VRK-1 and BAF-1 release meiotic chromosomes In this episode of PaperCast Base by Base, we explore VRK-1 phosphorylates BAF-1 to remov...
224: AntennAlive — wireless in-body sensing with engineered bacteria
10 Dec 2025
Contributed by Lukas
️ Episode 224: AntennAlive — wireless in-body sensing with engineered bacteria In this episode of PaperCast Base by Base, we explore A bio-hybrid,...
223: Torsion Regulates DNA Replication Stalling and Restart
09 Dec 2025
Contributed by Lukas
️ Episode 223: Torsion Regulates DNA Replication Stalling and Restart In this episode of PaperCast Base by Base, we explore New single-molecule angu...
222: snaR-A hijacks splicing to drive proliferation
08 Dec 2025
Contributed by Lukas
️ Episode 222: snaR-A hijacks splicing to drive proliferation In this episode of PaperCast Base by Base, we explore This episode examines how the ca...
221: Allele-resolved nanopore tour of the human placental methylome
07 Dec 2025
Contributed by Lukas
️ Episode 221: Allele-resolved nanopore tour of the human placental methylome In this episode of PaperCast Base by Base, we explore Using phased lon...
220: The AML cellular state space reveals NPM1 immune evasion subtypes
06 Dec 2025
Contributed by Lukas
️Episode 220: The AML cellular state space reveals NPM1 immune evasion subtypes In this episode of PaperCast Base by Base, we explore Single-cell an...
219: Multi-omic mapping of lipid dysregulation in Parkinson’s brain
05 Dec 2025
Contributed by Lukas
️Episode 219: Multi-omic mapping of lipid dysregulation in Parkinson’s brain In this episode of PaperCast Base by Base, we explore Targeted multi-...
218: SIM1 and the multi-ancestry genomics of erectile dysfunction
04 Dec 2025
Contributed by Lukas
️Episode 218: SIM1 and the multi-ancestry genomics of erectile dysfunction In this episode of PaperCast Base by Base, we explore A large multi-ance...
217: Multiscale triads of meiotic crossover patterning
03 Dec 2025
Contributed by Lukas
️Episode 217: Multiscale triads of meiotic crossover patterning In this episode of PaperCast Base by Base, we explore FFT and inverse-FFT analysis o...
216: 53BP1-RIF1 and DNA-PKcs: distinct interactions in chromosomal break repair
02 Dec 2025
Contributed by Lukas
️ Episode 216: 53BP1-RIF1 and DNA-PKcs: distinct interactions in chromosomal break repair In this episode of PaperCast Base by Base, we explore Thi...
215: Protein Set Transformer for high-diversity viromics
01 Dec 2025
Contributed by Lukas
️ Episode 215: Protein Set Transformer for high-diversity viromics In this episode of PaperCast Base by Base, we explore Protein Set Transformer (P...
214: PI(4,5)P2 Asymmetry Enables Rapid FGF2 Secretion
30 Nov 2025
Contributed by Lukas
️ Episode 214: PI(4,5)P2 Asymmetry Enables Rapid FGF2 Secretion In this episode of PaperCast Base by Base, we explore This study shows that an asymm...
213: BRAIN-MAGNET: a functional atlas for non-coding variants
29 Nov 2025
Contributed by Lukas
️ Episode 213: BRAIN-MAGNET: a functional atlas for non-coding variants In this episode of PaperCast Base by Base, we explore BRAIN-MAGNET couples ...
212: Zonal control of mutant β-catenin tumorigenesis
28 Nov 2025
Contributed by Lukas
️ Episode 212: Zonal control of mutant β-catenin tumorigenesis This study shows that hepatic zonation determines whether mutant β-catenin drives ...
211: Retention Elements in Cancer Cells
27 Nov 2025
Contributed by Lukas
️ Episode 211: Retention Elements in Cancer Cells In this episode of PaperCast Base by Base, we explore the discovery of genetic elements that prom...
210: Tumour-Reactive CD8 T Cell Clusters in Human Melanoma
26 Nov 2025
Contributed by Lukas
️ Episode 210: Tumour-Reactive CD8 T Cell Clusters in Human Melanoma In this episode of PaperCast Base by Base, we explore how tumour-reactive CD8 T...
209: PERT: Prime Editing tRNAs for Nonsense Mutations
25 Nov 2025
Contributed by Lukas
️ Episode 209: PERT: Prime Editing tRNAs for Nonsense Mutations In this episode of PaperCast Base by Base, we explore how prime editing can reprogr...
208: ZAK, Collided Ribosomes, and the Stress Switch
24 Nov 2025
Contributed by Lukas
️ Episode 208: ZAK, Collided Ribosomes, and the Stress Switch In this episode of PaperCast Base by Base, we explore how collided ribosomes activate...
207: Semantic Design of de novo Genes with Evo
24 Nov 2025
Contributed by Lukas
️ Episode 207: Semantic Design of de novo Genes with Evo In this episode of PaperCast Base by Base, we explore how a genomic language model called ...
206: Wild Birds and the North American H5N1 Epizootic
22 Nov 2025
Contributed by Lukas
️ Episode 206: Wild Birds and the North American H5N1 Epizootic In this episode of PaperCast Base by Base, we explore how wild migratory birds have ...
205: Ancient RNA Expression Profiles from the Woolly Mammoth
21 Nov 2025
Contributed by Lukas
️ Episode 205: Ancient RNA Expression Profiles from the Woolly Mammoth In this episode of PaperCast Base by Base, we explore how ancient RNA preser...
204: StealTHY CRISPR: Revealing Hidden Metastasis Regulators
20 Nov 2025
Contributed by Lukas
️ Episode 204: StealTHY CRISPR: Revealing Hidden Metastasis Regulators In this episode of PaperCast Base by Base, we explore how the StealTHY CRISP...
203: Divergent Evolutionary Dynamics of Benign and Malignant Tumors
19 Nov 2025
Contributed by Lukas
️ Episode 203: Divergent Evolutionary Dynamics of Benign and Malignant Tumors In this episode of PaperCast Base by Base, we explore how benign and m...
202: Stereo-seq V2: Spatial Total RNA Mapping in FFPE Tissues
19 Nov 2025
Contributed by Lukas
️ Episode 202: Stereo-seq V2: Spatial Total RNA Mapping in FFPE Tissues In this episode of PaperCast Base by Base, we explore how Stereo-seq V2 del...
201: Sex, Smoking, and Somatic Selection in the Bladder
17 Nov 2025
Contributed by Lukas
️ Episode 201: Sex, Smoking, and Somatic Selection in the Bladder In this episode of PaperCast Base by Base, we explore how ultradeep duplex DNA seq...
200: Sperm Sequencing Reveals Extensive Positive Selection in the Male Germline
16 Nov 2025
Contributed by Lukas
️ Episode 200: Sperm Sequencing Reveals Extensive Positive Selection in the Male Germline In this episode of PaperCast Base by Base, we explore how ...
199: PLD4 Deficiency and Lupus: When Nuclease Failure Ignites Autoimmunity
15 Nov 2025
Contributed by Lukas
️ Episode 199: PLD4 Deficiency and Lupus: When Nuclease Failure Ignites Autoimmunity In this episode of PaperCast Base by Base, we explore how loss...
198: Mechanical Confinement and the Shape-Shifting Life of Melanoma Cells
14 Nov 2025
Contributed by Lukas
️ Episode 198: Mechanical Confinement and the Shape-Shifting Life of Melanoma Cells In this episode of PaperCast Base by Base, we explore how physi...
197: Somatic Mutation and Selection at Population Scale
13 Nov 2025
Contributed by Lukas
️ Episode 197: Somatic Mutation and Selection at Population Scale In this episode of PaperCast Base by Base, we explore how ultra-accurate NanoSeq d...
196: Impact of Chromatin Accessibility QTLs Across Immune Contexts
12 Nov 2025
Contributed by Lukas
️ Episode 196: Impact of Chromatin Accessibility QTLs Across Immune Contexts In this episode of PaperCast Base by Base, we explore how single-cell ...
195: Tiny Shields: Lymphoid Microglia in Alzheimer’s Disease
11 Nov 2025
Contributed by Lukas
️ Episode 195: Tiny Shields: Lymphoid Microglia in Alzheimer’s Disease In this episode of PaperCast Base by Base, we explore how a subset of bra...
194: Bayesian History of Science: Watson and Crick and the Structure of DNA
10 Nov 2025
Contributed by Lukas
️ Episode 194: Bayesian History of Science: Watson and Crick and the Structure of DNA In this episode of PaperCast Base by Base, we explore how Baye...
193: SARM1, DNA, and the Death Signal
09 Nov 2025
Contributed by Lukas
️Episode 193: SARM1, DNA, and the Death Signal In this episode of PaperCast Base by Base, we explore how the axon-degenerating enzyme SARM1 acts as ...
192: At Base-Pair Resolution: Chromatin’s Cis-Regulatory Conversations
08 Nov 2025
Contributed by Lukas
️Episode 192: At Base-Pair Resolution: Chromatin’s Cis-Regulatory Conversations In this episode of PaperCast Base by Base, we explore how base-pai...
191: CATphishing: Synthetic Learning as an Alternative to Federated Learning in MRI
07 Nov 2025
Contributed by Lukas
️ Episode 191: CATphishing: Synthetic Learning as an Alternative to Federated Learning in MRI In this episode of PaperCast Base by Base, we explore...
190: Single-Cell Networks Reveal Cell Type–Specific Mechanisms in Type 2 Diabetes
06 Nov 2025
Contributed by Lukas
️ Episode 190: Single-Cell Networks Reveal Cell Type–Specific Mechanisms in Type 2 Diabetes In this episode of PaperCast Base by Base, we explore...
189: DNA methylation patterns facilitate tracing the origin of neuroendocrine neoplasms
05 Nov 2025
Contributed by Lukas
️ Episode 189: DNA methylation patterns facilitate tracing the origin of neuroendocrine neoplasms In this episode of PaperCast Base by Base, we exp...
188: Proteomics + Machine Learning for Lyme Neuroborreliosis Diagnosis
04 Nov 2025
Contributed by Lukas
️ Episode 188: Proteomics + Machine Learning for Lyme Neuroborreliosis Diagnosis In this episode of PaperCast Base by Base, we explore how large‑...
187: Gapped PARP + Tumor‑Targeted TOP1 in Advanced Tumors
03 Nov 2025
Contributed by Lukas
️ Episode 187: Gapped PARP + Tumor‑Targeted TOP1 in Advanced Tumors In this episode of PaperCast Base by Base, we explore a phase I dose‑escala...
186: TNFα–TGFβ Axis Disrupts Nasal Epithelium in Post‑COVID Syndrome
02 Nov 2025
Contributed by Lukas
️ Episode 186: TNFα–TGFβ Axis Disrupts Nasal Epithelium in Post‑COVID Syndrome In this episode of PaperCast Base by Base, we explore a single...
185: Altered Milk Tryptophan in Women Living with HIV
01 Nov 2025
Contributed by Lukas
️ Episode 185: Altered Milk Tryptophan in Women Living with HIV In this episode of PaperCast Base by Base, we explore a longitudinal metabolomics s...
184: High-Accuracy Multiethnic XGBoost for Skin Cancer Identification
31 Oct 2025
Contributed by Lukas
️ Episode 184: High-Accuracy Multiethnic XGBoost for Skin Cancer Identification In this episode of PaperCast Base by Base, we explore a large-scale...
183: The Genetic Lottery Goes to School: Better Schools Compensate for Genetic Differences
30 Oct 2025
Contributed by Lukas
️ Episode 183: The Genetic Lottery Goes to School: Better Schools Compensate for Genetic Differences In this episode of PaperCast Base by Base, we ...
182: Genotypic, Functional, and Phenotypic Characterization in CTNNB1 Neurodevelopmental Syndrome
29 Oct 2025
Contributed by Lukas
️ Episode 182: Genotypic, Functional, and Phenotypic Characterization in CTNNB1 Neurodevelopmental Syndrome In this episode of PaperCast Base by Ba...
181: Creatine Transporter SLC6A8: Conservation and Variant Impact
28 Oct 2025
Contributed by Lukas
️ Episode 181: Creatine Transporter SLC6A8: Conservation and Variant Impact In this episode of PaperCast Base by Base, we explore how the creatine ...
180: Leveraging Global Genetics Resources for Equitable Polygenic Prediction
27 Oct 2025
Contributed by Lukas
️ Episode 180: Leveraging Global Genetics Resources for Equitable Polygenic Prediction In this episode of PaperCast Base by Base, we explore how mu...
179: Mosaicism for Autosomal Trisomies: Maternal Age, UPD, and Reproductive History in 1,266 Cases
26 Oct 2025
Contributed by Lukas
️ Episode 179: Mosaicism for Autosomal Trisomies: Maternal Age, UPD, and Reproductive History in 1,266 Cases In this episode of PaperCast Base by Ba...
178: TP53 Reduced Penetrance: Predictive Features and Clinical Implications
25 Oct 2025
Contributed by Lukas
️ Episode 178: TP53 Reduced Penetrance: Predictive Features and Clinical Implications In this episode of PaperCast Base by Base, we explore how a l...
177: Biallelic MCM8/MCM9 Variants: From Hypogonadism to Cancer Predisposition
24 Oct 2025
Contributed by Lukas
️ Episode 177: Biallelic MCM8/MCM9 Variants: From Hypogonadism to Cancer Predisposition In this episode of PaperCast Base by Base, we explore a mul...
176: FAHD1 and the Pyruvate-Driven Evolution of Hepatocellular Carcinoma
23 Oct 2025
Contributed by Lukas
️ Episode 176: FAHD1 and the Pyruvate-Driven Evolution of Hepatocellular Carcinoma In this episode of PaperCast Base by Base, we explore how multi-...
175: Predictive Prioritization of Pancreatic Enhancers Linked to Disease Risk
22 Oct 2025
Contributed by Lukas
️ Episode 175: Predictive Prioritization of Pancreatic Enhancers Linked to Disease Risk In this episode of PaperCast Base by Base, we explore how en...
174: TMEM217–SLC9C1: Wiring the cAMP Switch for Sperm Motility and Male Fertility
21 Oct 2025
Contributed by Lukas
️ Episode 174: TMEM217–SLC9C1: Wiring the cAMP Switch for Sperm Motility and Male Fertility In this episode of PaperCast Base by Base, we explore...
173: Bottlebrush Block Copolymer Shields Muscles and Prevents DMD Onset
20 Oct 2025
Contributed by Lukas
️ Episode 173: Bottlebrush Block Copolymer Shields Muscles and Prevents DMD Onset In this episode of PaperCast Base by Base, we explore a PNAS stud...
172: When Random DNA Fights Back: De Novo Gene Birth as Antiphage Defense
19 Oct 2025
Contributed by Lukas
️ Episode 172: When Random DNA Fights Back: De Novo Gene Birth as Antiphage Defense In this episode of PaperCast Base by Base, we explore a PNAS st...
171: Virulence Hierarchies in the Tuberculosis Complex—What Makes Some Lineages Deadlier?
18 Oct 2025
Contributed by Lukas
️ Episode 171: Virulence Hierarchies in the Tuberculosis Complex—What Makes Some Lineages Deadlier? In this episode of PaperCast Base by Base, we...
170: Maternal Age, Meiotic Recombination Failure, and Triploidy in Humans
17 Oct 2025
Contributed by Lukas
️ Episode 170: Maternal Age, Meiotic Recombination Failure, and Triploidy in Humans In this episode of PaperCast Base by Base, we explore how mater...
169: Deep mutational scanning of the insulin receptor guides precision therapy for insulin resistance
16 Oct 2025
Contributed by Lukas
️ Episode 169: Deep mutational scanning of the insulin receptor guides precision therapy for insulin resistance In this episode of PaperCast Base b...
168: Low circulating miR-190a-5p predicts progression of chronic kidney disease
15 Oct 2025
Contributed by Lukas
️ Episode 168: Low circulating miR-190a-5p predicts progression of chronic kidney disease In this episode of PaperCast Base by Base, we explore how...
167: DeepScence: Detecting Senescent Cells at Single-Cell and Spatial Resolution
14 Oct 2025
Contributed by Lukas
️ Episode 167: DeepScence: Detecting Senescent Cells at Single-Cell and Spatial Resolution In this episode of PaperCast Base by Base, we explore a ...
166: Molecular Squeezing: How Coronin, Cofilin, and AIP1 Rapidly Disassemble Actin Filaments
13 Oct 2025
Contributed by Lukas
️ Episode 166: Molecular Squeezing: How Coronin, Cofilin, and AIP1 Rapidly Disassemble Actin Filaments In this episode of PaperCast Base by Base, w...
165: Protist Genomics: Key to Understanding Eukaryotic Evolution
12 Oct 2025
Contributed by Lukas
️ Episode 165: Protist Genomics: Key to Understanding Eukaryotic Evolution In this episode of PaperCast Base by Base, we explore how accelerating p...
164: m6A in the coding sequence: linking deposition, translation, and decay
11 Oct 2025
Contributed by Lukas
️ Episode 164: m6A in the coding sequence: linking deposition, translation, and decay In this episode of PaperCast Base by Base, we explore how N6-...
163: Animal origins: looping back in time
10 Oct 2025
Contributed by Lukas
️ Episode 163: Animal origins: looping back in time In this episode of PaperCast Base by Base, we explore how chromatin folding mechanisms emerged ...
162: Spatially Resolved microRNA Expression in Tissues: Technologies, Challenges, and Opportunities
09 Oct 2025
Contributed by Lukas
️ Episode 162: Spatially Resolved microRNA Expression in Tissues: Technologies, Challenges, and Opportunities In this episode of PaperCast Base by ...
161: Decoding Genomic Landscapes of Introgression
08 Oct 2025
Contributed by Lukas
️ Episode 161: Decoding Genomic Landscapes of Introgression In this episode of PaperCast Base by Base, we explore how modern population genetics di...
160: The Long‑Read Leap in Single‑Cell Omics
07 Oct 2025
Contributed by Lukas
️ Episode 160: The Long‑Read Leap in Single‑Cell Omics In this episode of PaperCast Base by Base, we explore how long‑read, single‑molecule...
159: The Untapped Potential of Short‑Read Sequencing in Biodiversity Research
06 Oct 2025
Contributed by Lukas
️ Episode 159: The Untapped Potential of Short‑Read Sequencing in Biodiversity Research In this episode of PaperCast Base by Base, we explore how...
158: Interruptions in Repeat Expansion Diseases: How Are They Gained and Lost?
05 Oct 2025
Contributed by Lukas
️ Episode 158: Interruptions in Repeat Expansion Diseases: How Are They Gained and Lost? In this episode of PaperCast Base by Base, we explore how s...
157: Synthetic gametes and the non-identity problem: the babies of tomorrow
04 Oct 2025
Contributed by Lukas
️ Episode 157: Synthetic gametes and the non-identity problem: the babies of tomorrow In this episode of PaperCast Base by Base, we explore how syn...
156: RAEFISH: Sequencing-free whole-genome spatial transcriptomics at single-molecule resolution
03 Oct 2025
Contributed by Lukas
️ Episode 156: RAEFISH: Sequencing-free whole-genome spatial transcriptomics at single-molecule resolution In this episode of PaperCast Base by Base...
155: EIF3A/EIF3B Loss-of-Function: A Cardiocraniofacial Neurodevelopmental Syndrome
02 Oct 2025
Contributed by Lukas
️ Episode 155: EIF3A/EIF3B Loss-of-Function: A Cardiocraniofacial Neurodevelopmental Syndrome In this episode of PaperCast Base by Base, we explore...
154: Multiple-testing corrections in selection scans using identity-by-descent segments
01 Oct 2025
Contributed by Lukas
️ Episode 154: Multiple-testing corrections in selection scans using identity-by-descent segments In this episode of PaperCast Base by Base, we exp...
153: Skeletal muscle eQTL meta-analysis implicates genes in the genetic architecture of muscular and cardiometabolic traits
30 Sep 2025
Contributed by Lukas
️ Episode 153: Skeletal muscle eQTL meta-analysis implicates genes in the genetic architecture of muscular and cardiometabolic traits In this episo...
152: One-Well Multiplex ddPCR for Hereditary Alpha Tryptasemia
29 Sep 2025
Contributed by Lukas
️ Episode 152: One-Well Multiplex ddPCR for Hereditary Alpha Tryptasemia In this episode of PaperCast Base by Base, we explore a validated single‑...
151: EQA of ctDNA Mutation Testing Across the COIN Consortium
28 Sep 2025
Contributed by Lukas
️ Episode 151: EQA of ctDNA Mutation Testing Across the COIN Consortium In this episode of PaperCast Base by Base, we explore how 16 Dutch laborato...
150: Patrilineal segmentary systems and the post‑Neolithic Y‑chromosome bottleneck
27 Sep 2025
Contributed by Lukas
️ Episode 150: Patrilineal segmentary systems and the post‑Neolithic Y‑chromosome bottleneck In this episode of PaperCast Base by Base, we expl...
149: Cultural Hitchhiking and the Post‑Neolithic Y‑Chromosome Bottleneck
26 Sep 2025
Contributed by Lukas
️ Episode 149: Cultural Hitchhiking and the Post‑Neolithic Y‑Chromosome Bottleneck In this episode of PaperCast Base by Base, we explore how pat...
148: Systematic Minigene-Based Splicing Analysis and Tentative Clinical Classification of 52 CHEK2 Splice-Site Variants
25 Sep 2025
Contributed by Lukas
️ Episode 148: Systematic Minigene-Based Splicing Analysis and Tentative Clinical Classification of 52 CHEK2 Splice-Site Variants In this episode o...
147: Comprehensive Annotation of Complete ABO Alleles and Resolution of ABO Variants
24 Sep 2025
Contributed by Lukas
️ Episode 147: Comprehensive Annotation of Complete ABO Alleles and Resolution of ABO Variants In this episode of PaperCast Base by Base, we explor...
146: Automated and Decentralized Genomic Profiling of Plasma Cell-Free DNA in Solid Tumors
23 Sep 2025
Contributed by Lukas
️ Episode 146: Automated and Decentralized Genomic Profiling of Plasma Cell-Free DNA in Solid Tumors In this episode of PaperCast Base by Base, we ...
145: A Validated Highly Sensitive Microsatellite Instability Assay Identifies PMS2 Variants in CMMRD
22 Sep 2025
Contributed by Lukas
️ Episode 145: A Validated Highly Sensitive Microsatellite Instability Assay Identifies PMS2 Variants in CMMRD In this episode of PaperCast Base by...
144: Revised time estimation of the ancestral human chromosome 2 fusion
21 Sep 2025
Contributed by Lukas
️ Episode 144: Revised time estimation of the ancestral human chromosome 2 fusion In this episode of PaperCast Base by Base, we explore a study tha...
143: The genetic history of the Southern Caucasus: 5,000 years of continuity despite high mobility
20 Sep 2025
Contributed by Lukas
️ Episode 143: The genetic history of the Southern Caucasus: 5,000 years of continuity despite high mobility In this episode of PaperCast Base by B...
142: Specifications of the ACMG/AMP Guidelines for PALB2 Variant Interpretation
19 Sep 2025
Contributed by Lukas
️ Episode 142: Specifications of the ACMG/AMP Guidelines for PALB2 Variant Interpretation In this episode of PaperCast Base by Base, we explore how...
141: RetiGene, a comprehensive gene atlas for inherited retinal diseases
18 Sep 2025
Contributed by Lukas
️ Episode 141: RetiGene, a comprehensive gene atlas for inherited retinal diseases In this episode of PaperCast Base by Base, we explore RetiGene, ...
140: Landscapes of missense variant impact for human superoxide dismutase 1
17 Sep 2025
Contributed by Lukas
️ Episode 140: Landscapes of missense variant impact for human superoxide dismutase 1 In this episode of PaperCast Base by Base, we explore a large...
139: MosCoverY: A new method to estimate mosaic loss of Y chromosome from sequencing coverage data
16 Sep 2025
Contributed by Lukas
️ Episode 139: MosCoverY: A new method to estimate mosaic loss of Y chromosome from sequencing coverage data In this episode of PaperCast Base by B...
138: Social exposome and brain health outcomes of dementia across Latin America
15 Sep 2025
Contributed by Lukas
️ Episode 138: Social exposome and brain health outcomes of dementia across Latin America In this episode of PaperCast Base by Base, we explore how...
137: Rethinking RNA-binding proteins: Riboregulation challenges prevailing views
14 Sep 2025
Contributed by Lukas
️ Episode 137: Rethinking RNA-binding proteins: Riboregulation challenges prevailing views In this episode of PaperCast Base by Base, we explore ho...
136: Gene Context Drift Identifies Drug Targets to Mitigate Cancer Treatment Resistance
13 Sep 2025
Contributed by Lukas
️ Episode 136: Gene Context Drift Identifies Drug Targets to Mitigate Cancer Treatment Resistance In this episode of PaperCast Base by Base, we exp...
135: Global impact of micronutrients in modern human evolution
12 Sep 2025
Contributed by Lukas
️ Episode 135: Global impact of micronutrients in modern human evolution In this episode of PaperCast Base by Base, we explore how dietary micronut...
134: Single-Cell Maps Link Intestinal Metaplasia to Esophageal Adenocarcinoma Risk
11 Sep 2025
Contributed by Lukas
️ Episode 134: Single-Cell Maps Link Intestinal Metaplasia to Esophageal Adenocarcinoma Risk In this episode of PaperCast Base by Base, we explore ...