Base by Base

325: cis-pcQTL mapping reveals allelic proxitropy across neighboring human genes

24 Mar 2026

Contributed by Lukas

Lawrence et al., Focus on single-gene effects limits discovery and interpretation of complex-trait-associated variants. The American Journal of Human ...

325: cis-pcQTL mapping reveals allelic proxitropy across neighboring human genes

24 Mar 2026

Contributed by Lukas

Lawrence et al., Focus on single-gene effects limits discovery and interpretation of complex-trait-associated variants. The American Journal of Human ...

324: ZSWIM8–CUL3 clamp on AGO2–miR-7 reveals mechanism of targeted microRNA degradation

23 Mar 2026

Contributed by Lukas

Farnung J et al., The E3 ubiquitin ligase mechanism specifying targeted microRNA degradation. Nature ( - Cryo-EM and biochemical reconstitution reveal...

323: Meat consumption and APOE ε3/ε4–ε4/ε4: slower cognitive decline and lower dementia risk in SNAC‑K

22 Mar 2026

Contributed by Lukas

Norgren J et al., JAMA Network Open - Population-based SNAC-K study finds higher meat consumption associated with slower cognitive decline and lower d...

322: Bi-allelic RNU6ATAC and RNU4ATAC variants cause infancy-onset autoimmune diabetes via minor spliceosome U12 intron retention

22 Mar 2026

Contributed by Lukas

Johnson MB et al., The American Journal of Human Genetics - Bi-allelic variants in snRNAs RNU6ATAC and RNU4ATAC cause infancy-onset autoimmune diabete...

321: Canonical nucleobases in asteroid (162173) Ryugu and ammonia-linked purine/pyrimidine ratios

20 Mar 2026

Contributed by Lukas

Koga T et al., et al. A complete set of canonical nucleobases in the carbonaceous asteroid (162173) Ryugu. Nature Astronomy ( - Ryugu asteroid samples...

320: Sex-stratified cQTL mapping identifies TOX (IFN-γ) and EGFR (IL-10) regulators in Dutch and Tanzanian cohorts

19 Mar 2026

Contributed by Lukas

Amour C et al., Human Genetics and Genomics Advances, Journal Pre-proof - Sex-stratified cQTL mapping in Tanzanian and Dutch adults identifies sex-spe...

319: Predicting reduced-penetrance TP53 variants from functional assays and random forest models

18 Mar 2026

Contributed by Lukas

Fortuno C et al., Human Genetics and Genomics Advances - TP53 germline variant analysis using functional assays finds reduced-penetrance variants have...

318: RNU6ATAC variants cause U6atac-driven minor spliceopathy with transcriptome-wide minor intron retention

18 Mar 2026

Contributed by Lukas

Mendez R et al., Human Genetics and Genomics Advances, Journal Pre-proof - Biallelic RNU6ATAC variants disrupt the U6atac minor spliceosomal snRNA, ca...

317: COPD sQTL colocalization in lung and blood identifies FBXO38 and BTC splicing mechanisms

16 Mar 2026

Contributed by Lukas

Saferali A et al., Human Genetics and Genomics Advances - RNA-seq in human lung (LTRC) and blood (COPDGene) reveals COPD-associated variants colocaliz...

316: Inclusion bias in UCLA ATLAS: enrollment models, weighting, and effects on GWAS and PGS

14 Mar 2026

Contributed by Lukas

Pimplaskar A et al., The American Journal of Human Genetics - In UCLA ATLAS EHR-linked biobank analyses, random forest-derived enrollment probabilitie...

315: PLE11-encoded Rta restricts ICP1 tail assembly in Vibrio cholerae outbreaks

12 Mar 2026

Contributed by Lukas

Mathur Y et al., E., Monir M. M., Islam M. T., Sultana M., Ahmed T., Alam M. & Seed K. D. Capturing dynamic phage–pathogen coevolution by clinic...

314: Proactive Genomic Reanalysis at Boston Children’s: VS-NN, HPO NLP and DRAGEN find diagnoses in pediatric ES/GS

11 Mar 2026

Contributed by Lukas

Rockowitz S et al., Scaling genomic reanalysis to unlock diagnoses and transform rare disease care. Human Genetics and Genomics Advances - Boston Chil...

313: Integrating Polygenic Risk Scores and Social Determinants of Health across Populations

10 Mar 2026

Contributed by Lukas

Cromer SJ et al., The American Journal of Human Genetics - This paper reviews polygenic risk scores (PRS) and social determinants of health (SDoH) and...

312: Mfsd2a transports LPC to maintain epidermal linoleate pools and desquamation

09 Mar 2026

Contributed by Lukas

Wong BHH et al., PNAS - Mouse and human studies show the LPC transporter Mfsd2a enables plasma-derived LPC uptake into keratinocytes, preserving linol...

311: mtG3PDH (GPO1) loss in Drosophila impairs mitochondrial ATP/O, O2 consumption, and ROS

08 Mar 2026

Contributed by Lukas

Herpe L et al., PNAS - CRISPR knockout of Drosophila mtG3PDH (GPO1) reduces ATP production by ~60% and O2 consumption by ~33%, lowering mitochondrial ...

310: Infant gut microbiota restoration — maternal FMT, Bifidobacterium and Bacteroides recovery after C‑section

07 Mar 2026

Contributed by Lukas

Korpela K et al., Gut Microbes - Review finds maternal fecal microbiota transplantation and targeted probiotics can restore Bifidobacterium and Bacter...

309: LASI-DAD 2,680-sample WGS panel boosts LD maps, imputation, and PRS in Indian genomes

06 Mar 2026

Contributed by Lukas

Li Z et al., Human Genetics and Genomics Advances. 7 ( - LASI-DAD 30× whole-genome sequencing of 2,680 Indian participants produced a 69.5M-variant L...

308: PANDORA-seq reveals conserved rsRNA length shift and tsRNA/rsRNA aging cliff in mouse and human sperm

05 Mar 2026

Contributed by Lukas

Shi J et al., The EMBO Journal - PANDORA-seq profiling of mouse and human sperm heads identifies a conserved rsRNA length shift with age and a tsRNA/r...

307: SNIPE membrane nuclease cleaves phage λ DNA during ManYZ-mediated genome injection in Escherichia coli

04 Mar 2026

Contributed by Lukas

Saxton DS et al., Nature - In E. coli, the membrane-bound nuclease SNIPE directly cleaves incoming phage λ DNA during genome injection, blocking infe...

306: SAXO6 loss-of-function in photoreceptor cilia links a microtubule inner protein to late-onset retinal dystrophy

03 Mar 2026

Contributed by Lukas

Moye AR et al., The American Journal of Human Genetics - Biallelic loss-of-function variants in SAXO6, a microtubule inner protein of photoreceptor ci...

305: Human cis-regulatory variants dissected by MPRA at single-nucleotide resolution

02 Mar 2026

Contributed by Lukas

Siraj L et al., Nature - Using MPRA in five human cell types, the authors assayed 221,412 fine-mapped variants and identified 13,121 trait-associated ...

304: Patrilineal Y‑chromosome drive in a Utah pedigree (67% male offspring)

02 Mar 2026

Contributed by Lukas

Baldwin-Brown JG et al., Annual Review of Ecology and Systematics - Bayesian analysis of 76,445 Utah Population Database pedigrees identifies a patril...

303: Short-read sequencing and genome skimming for biodiversity monitoring and phylogenomics

28 Feb 2026

Contributed by Lukas

Bleidorn C et al., Trends Genet - This review shows how short-read shotgun sequencing and genome skimming recover organellar genomes, estimate genome ...

302 auf Deutsch: SMN1/SMN2-Spleißen und Mechanismen im letzten Exon — Hommage an Brunhilde Wirth

27 Feb 2026

Contributed by Lukas

Ein Hommage-Dossier, das die wissenschaftliche Laufbahn von Prof. Brunhilde Wirth würdigt und Arbeiten zum alternativen Spleißen von SMN1/SMN2 hervo...

302: SMN1/SMN2 splicing and last-exon mechanisms — Tribute to Brunhilde Wirth

26 Feb 2026

Contributed by Lukas

The Last Exon Light: A Tribute Dossier Celebrating the Scientific Career of Prof et al., anonymous - Tribute to Prof. Brunhilde Wirth highlighting SMN...

290 Extra DE: SMN1-Exon-7-Deletionen p.Arg288AlafsTer5 entgehen dem PCR-Neugeborenenscreening und erzeugen dennoch eine funktionelle SMN-Isoform

26 Feb 2026

Contributed by Lukas

Wirth B et al. (The American Journal of Human Genetics, 2026) — Zwei 4-bp-Deletionen in Exon 7 von SMN1 (p.Arg288AlafsTer5) entgehen dem Standard-PC...

301: Biobank Mendelian randomization prioritizes 6,447 genes and nominates ANXA2 for dyslipidemia

25 Feb 2026

Contributed by Lukas

Ferolito BR et al., Human Genetics and Genomics Advances. 7 ( - Meta-analysis of MVP, UK Biobank and FinnGen with Mendelian randomization using eQTL/p...

300: Population-scale WGS links MHC class II antigen presentation to persistent Epstein–Barr virus (EBV) DNA

24 Feb 2026

Contributed by Lukas

Nyeo SS et al., Nature - Population-scale WGS reanalysis quantifies persistent EBV DNA and shows MHC class II–mediated antigen presentation predicts...

299: UFM1 loss and R81C mutation disrupt neuronal translation, ER stress, and synaptogenesis

24 Feb 2026

Contributed by Lukas

Perdigão C et al., EMBO Molecular Medicine - In mouse neurons, UFM1 loss or UFM1-R81C expression reduces protein translation, triggers ER stress and ...

298: Bi-allelic FSD1L variants in retinitis pigmentosa implicate photoreceptor axoneme

24 Feb 2026

Contributed by Lukas

Lin S et al., The American Journal of Human Genetics 113, 1–11 ( - Bi-allelic FSD1L variants cause retinitis pigmentosa; FSD1L localizes to the phot...

297: Bi-allelic FSD1L variants disrupt mitotic spindle and ciliogenesis in an L1-like neurodevelopmental disorder

24 Feb 2026

Contributed by Lukas

Serpieri V et al., The American Journal of Human Genetics. 113, 1–16 (March 5 - Bi-allelic FSD1L variants disrupt a microtubule-associated protein, ...

296: snaR-A ncRNA antagonizes U2 snRNP SF3B2 to drive intron retention in human cells

21 Feb 2026

Contributed by Lukas

Zhou S et al., Cancer-associated snaR-A noncoding RNA interacts with core splicing machinery and disrupts processing of mRNA subpopulations. Nature Co...

295: CFTR deltaF508 and CF-risk variants protect against IBD in large exome study

19 Feb 2026

Contributed by Lukas

Yu M et al., Cell Genomics. 6 ( - Large-scale exome sequencing shows CFTR risk variants, including deltaF508, reduce susceptibility to inflammatory bo...

294: Alternative splicing, exonization and lineage-specific isoforms: PTBP1, MAPT and TE-derived exons in mammalian evolution

18 Feb 2026

Contributed by Lukas

Hunter CE et al., The EMBO Journal - Review shows how alternative splicing, via TE exonization and cis-regulatory changes and revealed by long-read RN...

293: IndeLLM (ESM2) zero-shot scoring and Siamese transfer learning for in-frame indel prediction (MCC 0.77)

17 Feb 2026

Contributed by Lukas

Gracia Carmona O et al., Patterns. 7 ( - IndeLLM uses protein language models (ESM2) to score in-frame indels and a compact Siamese transfer-learning ...

292: INS R6C signal-peptide defect reduces preproinsulin ER translocation in iPSC-derived βcells

17 Feb 2026

Contributed by Lukas

Tong Y et al., EMBO Molecular Medicine - Patient data, population genetics and iPSC-derived βcell models show INS R6C impairs preproinsulin ER transl...

290: SMN1 p.Arg288AlafsTer5 exon 7 deletions evade PCR newborn screening yet yield functional SMN isoform

15 Feb 2026

Contributed by Lukas

Wirth B et al., The American Journal of Human Genetics - Two SMN1 exon 7 4-bp deletions (p.Arg288AlafsTer5) evade standard PCR newborn screening but p...

290: Dated gene duplications show Asgard archaeal host complexity before mitochondrial endosymbiosis

15 Feb 2026

Contributed by Lukas

Kay CJ et al., Nature 650, 129–140 ( - Relaxed-clock dating of pre-LECA gene duplications in Asgard archaeal and alphaproteobacterial lineages shows...

291: Dated gene duplications show Asgard archaeal host complexity before mitochondrial endosymbiosis

15 Feb 2026

Contributed by Lukas

Kay CJ et al., Nature 650, 129–140 ( - Relaxed-clock dating of pre-LECA gene duplications in Asgard archaeal and alphaproteobacterial lineages shows...

289: MinION detection of chimeric reads in murine Ifna/Ifnb and Actb amplicons

13 Feb 2026

Contributed by Lukas

White R et al., F1000Research - Nanopore MinION sequencing of murine Ifna, Ifnb and Actb amplicons identified post-amplification chimeric reads during...

288: Cryo-EM of rat cerebellar α1/α6 GABAA receptors reveals PZ‑II‑029 binding and β-α-β-α-γ assemblies

12 Feb 2026

Contributed by Lukas

Sun C et al., PNAS - Using cryo-EM and mass spectrometry in rat cerebellum, α1- and α6-containing GABAA receptor assemblies (β‑α‑β‑α‑γ ...

287: EPOP and MTF2 modulate PRC2 H3K27me3 deposition via GA- and GCN-sequence specificity

11 Feb 2026

Contributed by Lukas

Granata J et al., PNAS - In mESCs and defined in vitro assays, EPOP and MTF2 stimulate PRC2 methyltransferase activity and promote de novo H3K27me3 de...

286: Deep mutational scanning of Nipah virus fusion protein F reveals functional and antigenic constraints

10 Feb 2026

Contributed by Lukas

Larsen BB et al., PNAS - Deep mutational scanning of the Nipah virus fusion protein F using pseudoviruses maps ~8,500 single-residue effects, showing ...

285: ESBX (Tb927.3.1660) integrates ESB RNA Pol I localization with BES activation and VSG repression in Trypanosoma brucei

09 Feb 2026

Contributed by Lukas

Berazategui MA et al., PNAS - ESBX (Tb927.3.1660) links RNA Pol I localization at the ESB to activation of the active BES and repression of inactive B...

284: FES, VSMC behavior and pleiotropic vascular genes identified by integrative functional genomics

08 Feb 2026

Contributed by Lukas

Solomon CU et al., Nat Commun ( - Integrative analysis in human VSMCs identifies pleiotropic genes including FES that regulate vascular remodeling; po...

283: Confidence in genetic knowledge drives Familiarity, Knowledge, and Skills in US GALS samples

07 Feb 2026

Contributed by Lukas

Ramírez Renta GM et al., The American Journal of Human Genetics - GALS survey of >4,000 US respondents (GenPop and SPARK) shows confidence in gene...

283: Confidence in genetic knowledge drives Familiarity, Knowledge, and Skills in US GALS samples

07 Feb 2026

Contributed by Lukas

Ramírez Renta GM et al., The American Journal of Human Genetics - GALS survey of >4,000 US respondents (GenPop and SPARK) shows confidence in gene...

282: Gene-specific variance-control corrects polygenicity-driven inflation in TWAS

06 Feb 2026

Contributed by Lukas

Liang Y et al., The American Journal of Human Genetics. 113 ( - TWAS using genetically predicted expression exhibit polygenicity-driven inflation that...

281: Variant-level mapping of ACTB and ACTG1 defines eight non-muscle actinopathies and links BWCFF to actin polymerization defects

06 Feb 2026

Contributed by Lukas

Di Donato N et al., The American Journal of Human Genetics. 113:324-341 ( - Analysis of 290 individuals with ACTB and ACTG1 variants defines eight dis...

280: SCD, FADS and a 3p25.2 (PPARG) locus shape fatty acid composition in human subcutaneous adipose tissue

04 Feb 2026

Contributed by Lukas

Yan X et al., The American Journal of Human Genetics, Corrected proof - In 569 TwinsUK subcutaneous adipose biopsies, twin models and GWAS identify SC...

279: Against the Uncritical Adoption of AI in Universities: LLMs, Chatbots, and Academic Integrity (Guest et al.)

03 Feb 2026

Contributed by Lukas

Guest, O et al., Zenodo (2025) - Position piece urging universities to resist uncritical adoption of AI technologies such as LLMs and chatbots becaus...

278: Illumina, Grail and FTC scrutiny of vertical mergers in human genetic technologies

02 Feb 2026

Contributed by Lukas

Rashid AI et al., The American Journal of Human Genetics - US antitrust shifts in human genetic technologies: FTC scrutiny of Illumina’s acquisition...

277: MDGA2 homozygous loss-of-function variants in developmental and epileptic encephalopathy

01 Feb 2026

Contributed by Lukas

Morsy H et al., The American Journal of Human Genetics - Exome sequencing identifies homozygous MDGA2 loss-of-function variants in nine individuals an...

276: AlphaGenome: 1-Mb multimodal deep model predicts regulatory variant effects including splicing and TAL1 mechanisms

30 Jan 2026

Contributed by Lukas

Avsec et al., Advancing regulatory variant effect prediction with AlphaGenome. Nature 649, 1206–1218 ( - AlphaGenome, a 1 Mb DNA deep‑learning mod...

275: MIPseq/WES of 11,555 CHD probands implicates 60 dominant genes with NOTCH1 cysteine‑altering and transmitted MYH6 missense variants

30 Jan 2026

Contributed by Lukas

Sierant MC et al., PNAS - MIPseq and exome sequencing of 11,555 human congenital heart disease probands implicate 60 dominant CHD genes, with NOTCH1 c...

274: RPE-specific MCT2 gene delivery preserves cones and vision in rat and mouse models of retinitis pigmentosa

29 Jan 2026

Contributed by Lukas

Chandler LC et al., PNAS - AAV-mediated RPE expression of MCT2 in rat and mouse retinitis pigmentosa models increases RPE lactate uptake and prolongs ...

273: CTVT-A acquires 15-Mb N-HT1 dicentric nuclear element via horizontal transfer

28 Jan 2026

Contributed by Lukas

Gori K et al., PNAS - In canine transmissible venereal tumor (CTVT), deep sequencing and cytogenetics identify a 15‑Mb horizontally transferred nucl...

272: ADSL A429V reduces purine biosynthesis in brain and alters female mouse water-seeking behavior

27 Jan 2026

Contributed by Lukas

Ju X-C et al., PNAS - Human-specific ADSL A429V substitution and a common regulatory haplotype reduce ADSL activity and raise purine substrates in the...

271: Rising EA PGI prediction of educational attainment across 1946–1970 British birth cohorts and socioeconomic interaction

25 Jan 2026

Contributed by Lukas

Morris TT et al., PNAS - EA and cognition polygenic indexes (PGIs) in three British birth cohorts show EA PGI associations with years of education inc...

270: Human Topoisomerase IIIα–RMI1–RMI2 (TRR) processively relaxes negatively supercoiled DNA measured by optical tweezers

25 Jan 2026

Contributed by Lukas

Spakmana D et al., H., Hickson I. D., Peterman E. J. G., Wuite G. J. L., King G. A. Mechanistic basis for relaxation of DNA supercoils by human topois...

269: Mlh1–Pms1 endonuclease creates single-strand gaps to excise mispairs in S. cerevisiae MMR

24 Jan 2026

Contributed by Lukas

Palacio T et al., PNAS - Reconstituted Saccharomyces cerevisiae mismatch repair shows the Mlh1–Pms1 endonuclease directly generates single-strand ga...

268: M493I in human β-cardiac myosin: SRX disruption, slow ADP release, and enhanced actin attachment

23 Jan 2026

Contributed by Lukas

Cail RC et al., PNAS - Recombinant human β-cardiac myosin M493I studied by optical trapping and stopped-flow kinetics disrupts the super-relaxed stat...

267: DNA base-pair opening modes and soliton-like loops revealed by hydrogen exchange

22 Jan 2026

Contributed by Lukas

Englander SW et al., PNAS - Hydrogen exchange (H-T and NMR H-H) on DNA and RNA reveals two distinct base-pair opening modes: single-base microsecond o...

266: TOP1α and TOP3β Differentially Regulate HPV31 Replication via R-loops and DNA Breaks

21 Jan 2026

Contributed by Lukas

Vatsa A et al., PNAS - In HPV31-positive keratinocytes (CIN612), TOP1α and TOP3β are upregulated and required for viral transcription and replicatio...

265: ANTSR lncRNA and the conserved multiallelic sex-determining locus across Aculeata

20 Jan 2026

Contributed by Lukas

Yu C et al., Proc. Natl. Acad. Sci. U.S.A - Genetic mapping and comparative genomics show the lncRNA ANTSR multiallelic locus in Aculeata directs fema...

264: Single-TF rejuvenation: EZH2, E2F3, STAT3, ZFX identified by TRDP/Perturb-seq rejuvenate human fibroblasts and mouse liver

19 Jan 2026

Contributed by Lukas

Sengstack J et al., Proc. Natl. Acad. Sci. U.S.A - TRDP with Perturb-seq in human fibroblasts found that manipulating TFs (EZH2, E2F3, STAT3, ZFX) rev...

263: Bifacial γPNA triplets target rCUG repeats and displace MBNL1 in Myotonic Dystrophy type 1

18 Jan 2026

Contributed by Lukas

Perera J et al., R., Thadke S. A., Thrikawala S. W., Wilson W. D., Tan K. W. R., Chand N. Z. W., Phan A. T., Ly D. H., et al. A pothole-filling strate...

262: Human Langerhans cells reprogrammed by tick saliva (CXCR4/CCR7 migration and IDO1/IRF4 tolerance)

17 Jan 2026

Contributed by Lukas

Strobl et al., & Stary, G. Human epidermal Langerhans cells induce tolerance and hamper T cell function upon tick-borne pathogen transmission. Nat...

261: MHz-XPCS reveals anomalous ferritin diffusion and nanoscale cage trapping

16 Jan 2026

Contributed by Lukas

Girelli et al., Coherent X-rays reveal anomalous molecular diffusion and cage effects in crowded protein solutions. Nat Commun ( - MHz-XPCS of ferriti...

260: TSS hypermutability in human germline linked to RNAP II stalling, R-loops and early embryonic mosaics

15 Jan 2026

Contributed by Lukas

Cortés Guzmán M et al., Nat Commun - Human germline transcription start sites show a hotspot of non-CpG variants driven by the early embryonic mosai...

259: Ku filaments that hold DNA together

14 Jan 2026

Contributed by Lukas

Zahid S et al., Nat Commun - Cryo-EM and biophysical analyses show Mycobacterium tuberculosis Ku assembles into DNA-bound oligomeric filaments that sy...

258: Correcting GC bias in metagenomes

13 Jan 2026

Contributed by Lukas

Holcik L et al., Genomic GC bias correction improves species abundance estimation from metagenomic data. Nature Communications - GuaCAMOLE is an align...

257: PSMC5: proteasomes, immunity and neurodevelopment

12 Jan 2026

Contributed by Lukas

Küry S et al., Nat Commun - This study describes 26 distinct PSMC5 variants in 44 individuals and demonstrates that PSMC5 loss impairs proteasome fun...

256: Compartmental control of VSG silencing

11 Jan 2026

Contributed by Lukas

Antunes et al., Chromosome compartment assembly is essential for subtelomeric gene silencing in trypanosomes. Nat Commun ( - The study shows that spat...

255: Lipids, Ions and the AE1 Elevator

10 Jan 2026

Contributed by Lukas

Chen T et al., Nat Commun - Cryo-EM structures, uptake assays, and molecular dynamics show that PIP2 lipids bind at the AE1 dimer interface and inhibi...

254: Rescuing the replisome at a nick

09 Jan 2026

Contributed by Lukas

Winterhalter et al., Rescuing the bacterial replisome at a nick requires recombinational repair and helicase reloading. Nat Commun ( - Cas9 nickases i...

253: Nap1 and histone acetylation tune chromatin condensates

08 Jan 2026

Contributed by Lukas

Gao J et al., Nat Commun - H4 tail lysine residues drive liquid-liquid phase separation of 12‑mer nucleosome arrays, while H3 tail acetylation and t...

252: Keratinocytes to cSCC: genetic steps

07 Jan 2026

Contributed by Lukas

️ Episode 252: Keratinocytes to cSCC: genetic steps In this episode of PaperCast Base by Base, we explore Single-cell and spatial multi-omic profil...

251: MuSCs, laminin-α2 and LAMA2 MD

06 Jan 2026

Contributed by Lukas

️ Episode 251: MuSCs, laminin-α2 and LAMA2 MD In this episode of PaperCast Base by Base, we explore Activated muscle stem cells express and secret...

250: CIP2A–TOPBP1: Mitotic repair via MiDAS and MMEJ

05 Jan 2026

Contributed by Lukas

️ Episode 250: CIP2A–TOPBP1: Mitotic repair via MiDAS and MMEJ In this episode of PaperCast Base by Base, we explore This study shows the CIP2A-T...

249: PCM1 links centrosome asymmetry to endosome dynamics

04 Jan 2026

Contributed by Lukas

️ Episode 249: PCM1 links centrosome asymmetry to endosome dynamics In this episode of PaperCast Base by Base, we explore In developing neural prog...

248: Disruption of PIKfyve triggers lysosomal repair and mitochondrial adaptation

03 Jan 2026

Contributed by Lukas

️ Episode 248: Disruption of PIKfyve triggers lysosomal repair and mitochondrial adaptation In this episode of PaperCast Base by Base, we explore D...

247: Genome graphs reveal structural variation in M. tuberculosis

02 Jan 2026

Contributed by Lukas

️ Episode 247: Genome graphs reveal structural variation in M. tuberculosis In this episode of PaperCast Base by Base, we explore Long-read assembl...

246: SV2A structural pharmacology and allosteric occlusion

01 Jan 2026

Contributed by Lukas

️ Episode 246: SV2A structural pharmacology and allosteric occlusion In this episode of PaperCast Base by Base, we explore High-resolution cryo-EM ...

245: Benchmarking DNA foundation models

31 Dec 2025

Contributed by Lukas

️ Episode 245: Benchmarking DNA foundation models In this episode of PaperCast Base by Base, we explore A comprehensive, unbiased benchmark compare...

244: NEK7 couples SDHB to preserve mitochondrial electron transport and limit liver fibrosis

30 Dec 2025

Contributed by Lukas

️ Episode 244: NEK7 couples SDHB to preserve mitochondrial electron transport and limit liver fibrosis In this episode of PaperCast Base by Base, w...

243: Genome-wide UVB GxE study finds 162 vitamin D variants

29 Dec 2025

Contributed by Lukas

️ Episode 243: Genome-wide UVB GxE study finds 162 vitamin D variants In this episode of PaperCast Base by Base, we explore A GWIS of 338,977 UK Bi...

242: AAV9-fcMISv2 gene therapy prevents pregnancy in female cats

28 Dec 2025

Contributed by Lukas

️ Episode 242: AAV9-fcMISv2 gene therapy prevents pregnancy in female cats In this episode of PaperCast Base by Base, we explore A single intramusc...

241: Wagyu T2T reveals a cattle X neocentromere

27 Dec 2025

Contributed by Lukas

️ Episode 241: Wagyu T2T reveals a cattle X neocentromere In this episode of PaperCast Base by Base, we explore A telomere-to-telomere Wagyu assemb...

240: CYFIP1 controls cortical axon development by modulating calcium

26 Dec 2025

Contributed by Lukas

️ Episode 240: CYFIP1 controls cortical axon development by modulating calcium In this episode of PaperCast Base by Base, we explore Reduction of CY...

239: Genomic Adaptations of the Svalbard Reindeer

25 Dec 2025

Contributed by Lukas

️ Episode 239: Genomic Adaptations of the Svalbard Reindeer In this episode of PaperCast Base by Base, we explore Comparative whole-genome analyses...

238: Germline polymorphisms shape antibody light chain repertoires

24 Dec 2025

Contributed by Lukas

️ Episode 238: Germline polymorphisms shape antibody light chain repertoires In this episode of PaperCast Base by Base, we explore Long-read sequen...

237: Tracing enteric pathogens in Africa with metagenomics and WGS

23 Dec 2025

Contributed by Lukas

️ Episode 237: Tracing enteric pathogens in Africa with metagenomics and WGS In this episode of PaperCast Base by Base, we explore This study combin...

236: XPD translocation and genetic disease etiology

22 Dec 2025

Contributed by Lukas

️ Episode 236: XPD translocation and genetic disease etiology In this episode of PaperCast Base by Base, we explore Computational modeling reveals ...

235: Maternal H3K9 methyltransferases control aRMAE in C. elegans

21 Dec 2025

Contributed by Lukas

️ Episode 235: Maternal H3K9 methyltransferases control aRMAE in C. elegans In this episode of PaperCast Base by Base, we explore Using dual-color ...

234: MTHFR genotype and methionine metabolism predict COVID-19 severity

20 Dec 2025

Contributed by Lukas

️ Episode 234: MTHFR genotype and methionine metabolism predict COVID-19 severity In this episode of PaperCast Base by Base, we explore IMPACC long...

233: Mechanistic basis of NuA3 recognition and H3K14 acetylation

19 Dec 2025

Contributed by Lukas

️ Episode 233: Mechanistic basis of NuA3 recognition and H3K14 acetylation In this episode of PaperCast Base by Base, we explore Cryo-EM structures...

232: Lamin A/C steers fork restart via H3K9me3 and PARylation

18 Dec 2025

Contributed by Lukas

️Episode 232: Lamin A/C steers fork restart via H3K9me3 and PARylation In this episode of PaperCast Base by Base, we explore Nucleoplasmic Lamin A/C...

231: Transcription start sites as a germline mutational hotspot

17 Dec 2025

Contributed by Lukas

️Episode 231: Transcription start sites as a germline mutational hotspot In this episode of PaperCast Base by Base, we explore This study identifies...