Base by Base

280: SCD, FADS and a 3p25.2 (PPARG) locus shape fatty acid composition in human subcutaneous adipose tissue

04 Feb 2026

Contributed by Lukas

Yan X et al., The American Journal of Human Genetics, Corrected proof - In 569 TwinsUK subcutaneous adipose biopsies, twin models and GWAS identify SC...

279: Against the Uncritical Adoption of AI in Universities: LLMs, Chatbots, and Academic Integrity (Guest et al.)

03 Feb 2026

Contributed by Lukas

Guest, O et al., Zenodo (2025) - Position piece urging universities to resist uncritical adoption of AI technologies such as LLMs and chatbots becaus...

278: Illumina, Grail and FTC scrutiny of vertical mergers in human genetic technologies

02 Feb 2026

Contributed by Lukas

Rashid AI et al., The American Journal of Human Genetics - US antitrust shifts in human genetic technologies: FTC scrutiny of Illumina’s acquisition...

277: MDGA2 homozygous loss-of-function variants in developmental and epileptic encephalopathy

01 Feb 2026

Contributed by Lukas

Morsy H et al., The American Journal of Human Genetics - Exome sequencing identifies homozygous MDGA2 loss-of-function variants in nine individuals an...

276: AlphaGenome: 1-Mb multimodal deep model predicts regulatory variant effects including splicing and TAL1 mechanisms

30 Jan 2026

Contributed by Lukas

Avsec et al., Advancing regulatory variant effect prediction with AlphaGenome. Nature 649, 1206–1218 ( - AlphaGenome, a 1 Mb DNA deep‑learning mod...

275: MIPseq/WES of 11,555 CHD probands implicates 60 dominant genes with NOTCH1 cysteine‑altering and transmitted MYH6 missense variants

30 Jan 2026

Contributed by Lukas

Sierant MC et al., PNAS - MIPseq and exome sequencing of 11,555 human congenital heart disease probands implicate 60 dominant CHD genes, with NOTCH1 c...

274: RPE-specific MCT2 gene delivery preserves cones and vision in rat and mouse models of retinitis pigmentosa

29 Jan 2026

Contributed by Lukas

Chandler LC et al., PNAS - AAV-mediated RPE expression of MCT2 in rat and mouse retinitis pigmentosa models increases RPE lactate uptake and prolongs ...

273: CTVT-A acquires 15-Mb N-HT1 dicentric nuclear element via horizontal transfer

28 Jan 2026

Contributed by Lukas

Gori K et al., PNAS - In canine transmissible venereal tumor (CTVT), deep sequencing and cytogenetics identify a 15‑Mb horizontally transferred nucl...

272: ADSL A429V reduces purine biosynthesis in brain and alters female mouse water-seeking behavior

27 Jan 2026

Contributed by Lukas

Ju X-C et al., PNAS - Human-specific ADSL A429V substitution and a common regulatory haplotype reduce ADSL activity and raise purine substrates in the...

271: Rising EA PGI prediction of educational attainment across 1946–1970 British birth cohorts and socioeconomic interaction

25 Jan 2026

Contributed by Lukas

Morris TT et al., PNAS - EA and cognition polygenic indexes (PGIs) in three British birth cohorts show EA PGI associations with years of education inc...

270: Human Topoisomerase IIIα–RMI1–RMI2 (TRR) processively relaxes negatively supercoiled DNA measured by optical tweezers

25 Jan 2026

Contributed by Lukas

Spakmana D et al., H., Hickson I. D., Peterman E. J. G., Wuite G. J. L., King G. A. Mechanistic basis for relaxation of DNA supercoils by human topois...

269: Mlh1–Pms1 endonuclease creates single-strand gaps to excise mispairs in S. cerevisiae MMR

24 Jan 2026

Contributed by Lukas

Palacio T et al., PNAS - Reconstituted Saccharomyces cerevisiae mismatch repair shows the Mlh1–Pms1 endonuclease directly generates single-strand ga...

268: M493I in human β-cardiac myosin: SRX disruption, slow ADP release, and enhanced actin attachment

23 Jan 2026

Contributed by Lukas

Cail RC et al., PNAS - Recombinant human β-cardiac myosin M493I studied by optical trapping and stopped-flow kinetics disrupts the super-relaxed stat...

267: DNA base-pair opening modes and soliton-like loops revealed by hydrogen exchange

22 Jan 2026

Contributed by Lukas

Englander SW et al., PNAS - Hydrogen exchange (H-T and NMR H-H) on DNA and RNA reveals two distinct base-pair opening modes: single-base microsecond o...

266: TOP1α and TOP3β Differentially Regulate HPV31 Replication via R-loops and DNA Breaks

21 Jan 2026

Contributed by Lukas

Vatsa A et al., PNAS - In HPV31-positive keratinocytes (CIN612), TOP1α and TOP3β are upregulated and required for viral transcription and replicatio...

265: ANTSR lncRNA and the conserved multiallelic sex-determining locus across Aculeata

20 Jan 2026

Contributed by Lukas

Yu C et al., Proc. Natl. Acad. Sci. U.S.A - Genetic mapping and comparative genomics show the lncRNA ANTSR multiallelic locus in Aculeata directs fema...

264: Single-TF rejuvenation: EZH2, E2F3, STAT3, ZFX identified by TRDP/Perturb-seq rejuvenate human fibroblasts and mouse liver

19 Jan 2026

Contributed by Lukas

Sengstack J et al., Proc. Natl. Acad. Sci. U.S.A - TRDP with Perturb-seq in human fibroblasts found that manipulating TFs (EZH2, E2F3, STAT3, ZFX) rev...

263: Bifacial γPNA triplets target rCUG repeats and displace MBNL1 in Myotonic Dystrophy type 1

18 Jan 2026

Contributed by Lukas

Perera J et al., R., Thadke S. A., Thrikawala S. W., Wilson W. D., Tan K. W. R., Chand N. Z. W., Phan A. T., Ly D. H., et al. A pothole-filling strate...

262: Human Langerhans cells reprogrammed by tick saliva (CXCR4/CCR7 migration and IDO1/IRF4 tolerance)

17 Jan 2026

Contributed by Lukas

Strobl et al., & Stary, G. Human epidermal Langerhans cells induce tolerance and hamper T cell function upon tick-borne pathogen transmission. Nat...

261: MHz-XPCS reveals anomalous ferritin diffusion and nanoscale cage trapping

16 Jan 2026

Contributed by Lukas

Girelli et al., Coherent X-rays reveal anomalous molecular diffusion and cage effects in crowded protein solutions. Nat Commun ( - MHz-XPCS of ferriti...

260: TSS hypermutability in human germline linked to RNAP II stalling, R-loops and early embryonic mosaics

15 Jan 2026

Contributed by Lukas

Cortés Guzmán M et al., Nat Commun - Human germline transcription start sites show a hotspot of non-CpG variants driven by the early embryonic mosai...

259: Ku filaments that hold DNA together

14 Jan 2026

Contributed by Lukas

Zahid S et al., Nat Commun - Cryo-EM and biophysical analyses show Mycobacterium tuberculosis Ku assembles into DNA-bound oligomeric filaments that sy...

258: Correcting GC bias in metagenomes

13 Jan 2026

Contributed by Lukas

Holcik L et al., Genomic GC bias correction improves species abundance estimation from metagenomic data. Nature Communications - GuaCAMOLE is an align...

257: PSMC5: proteasomes, immunity and neurodevelopment

12 Jan 2026

Contributed by Lukas

Küry S et al., Nat Commun - This study describes 26 distinct PSMC5 variants in 44 individuals and demonstrates that PSMC5 loss impairs proteasome fun...

256: Compartmental control of VSG silencing

11 Jan 2026

Contributed by Lukas

Antunes et al., Chromosome compartment assembly is essential for subtelomeric gene silencing in trypanosomes. Nat Commun ( - The study shows that spat...

255: Lipids, Ions and the AE1 Elevator

10 Jan 2026

Contributed by Lukas

Chen T et al., Nat Commun - Cryo-EM structures, uptake assays, and molecular dynamics show that PIP2 lipids bind at the AE1 dimer interface and inhibi...

254: Rescuing the replisome at a nick

09 Jan 2026

Contributed by Lukas

Winterhalter et al., Rescuing the bacterial replisome at a nick requires recombinational repair and helicase reloading. Nat Commun ( - Cas9 nickases i...

253: Nap1 and histone acetylation tune chromatin condensates

08 Jan 2026

Contributed by Lukas

Gao J et al., Nat Commun - H4 tail lysine residues drive liquid-liquid phase separation of 12‑mer nucleosome arrays, while H3 tail acetylation and t...

252: Keratinocytes to cSCC: genetic steps

07 Jan 2026

Contributed by Lukas

️ Episode 252: Keratinocytes to cSCC: genetic steps In this episode of PaperCast Base by Base, we explore Single-cell and spatial multi-omic profil...

251: MuSCs, laminin-α2 and LAMA2 MD

06 Jan 2026

Contributed by Lukas

️ Episode 251: MuSCs, laminin-α2 and LAMA2 MD In this episode of PaperCast Base by Base, we explore Activated muscle stem cells express and secret...

250: CIP2A–TOPBP1: Mitotic repair via MiDAS and MMEJ

05 Jan 2026

Contributed by Lukas

️ Episode 250: CIP2A–TOPBP1: Mitotic repair via MiDAS and MMEJ In this episode of PaperCast Base by Base, we explore This study shows the CIP2A-T...

249: PCM1 links centrosome asymmetry to endosome dynamics

04 Jan 2026

Contributed by Lukas

️ Episode 249: PCM1 links centrosome asymmetry to endosome dynamics In this episode of PaperCast Base by Base, we explore In developing neural prog...

248: Disruption of PIKfyve triggers lysosomal repair and mitochondrial adaptation

03 Jan 2026

Contributed by Lukas

️ Episode 248: Disruption of PIKfyve triggers lysosomal repair and mitochondrial adaptation In this episode of PaperCast Base by Base, we explore D...

247: Genome graphs reveal structural variation in M. tuberculosis

02 Jan 2026

Contributed by Lukas

️ Episode 247: Genome graphs reveal structural variation in M. tuberculosis In this episode of PaperCast Base by Base, we explore Long-read assembl...

246: SV2A structural pharmacology and allosteric occlusion

01 Jan 2026

Contributed by Lukas

️ Episode 246: SV2A structural pharmacology and allosteric occlusion In this episode of PaperCast Base by Base, we explore High-resolution cryo-EM ...

245: Benchmarking DNA foundation models

31 Dec 2025

Contributed by Lukas

️ Episode 245: Benchmarking DNA foundation models In this episode of PaperCast Base by Base, we explore A comprehensive, unbiased benchmark compare...

244: NEK7 couples SDHB to preserve mitochondrial electron transport and limit liver fibrosis

30 Dec 2025

Contributed by Lukas

️ Episode 244: NEK7 couples SDHB to preserve mitochondrial electron transport and limit liver fibrosis In this episode of PaperCast Base by Base, w...

243: Genome-wide UVB GxE study finds 162 vitamin D variants

29 Dec 2025

Contributed by Lukas

️ Episode 243: Genome-wide UVB GxE study finds 162 vitamin D variants In this episode of PaperCast Base by Base, we explore A GWIS of 338,977 UK Bi...

242: AAV9-fcMISv2 gene therapy prevents pregnancy in female cats

28 Dec 2025

Contributed by Lukas

️ Episode 242: AAV9-fcMISv2 gene therapy prevents pregnancy in female cats In this episode of PaperCast Base by Base, we explore A single intramusc...

241: Wagyu T2T reveals a cattle X neocentromere

27 Dec 2025

Contributed by Lukas

️ Episode 241: Wagyu T2T reveals a cattle X neocentromere In this episode of PaperCast Base by Base, we explore A telomere-to-telomere Wagyu assemb...

240: CYFIP1 controls cortical axon development by modulating calcium

26 Dec 2025

Contributed by Lukas

️ Episode 240: CYFIP1 controls cortical axon development by modulating calcium In this episode of PaperCast Base by Base, we explore Reduction of CY...

239: Genomic Adaptations of the Svalbard Reindeer

25 Dec 2025

Contributed by Lukas

️ Episode 239: Genomic Adaptations of the Svalbard Reindeer In this episode of PaperCast Base by Base, we explore Comparative whole-genome analyses...

238: Germline polymorphisms shape antibody light chain repertoires

24 Dec 2025

Contributed by Lukas

️ Episode 238: Germline polymorphisms shape antibody light chain repertoires In this episode of PaperCast Base by Base, we explore Long-read sequen...

237: Tracing enteric pathogens in Africa with metagenomics and WGS

23 Dec 2025

Contributed by Lukas

️ Episode 237: Tracing enteric pathogens in Africa with metagenomics and WGS In this episode of PaperCast Base by Base, we explore This study combin...

236: XPD translocation and genetic disease etiology

22 Dec 2025

Contributed by Lukas

️ Episode 236: XPD translocation and genetic disease etiology In this episode of PaperCast Base by Base, we explore Computational modeling reveals ...

235: Maternal H3K9 methyltransferases control aRMAE in C. elegans

21 Dec 2025

Contributed by Lukas

️ Episode 235: Maternal H3K9 methyltransferases control aRMAE in C. elegans In this episode of PaperCast Base by Base, we explore Using dual-color ...

234: MTHFR genotype and methionine metabolism predict COVID-19 severity

20 Dec 2025

Contributed by Lukas

️ Episode 234: MTHFR genotype and methionine metabolism predict COVID-19 severity In this episode of PaperCast Base by Base, we explore IMPACC long...

233: Mechanistic basis of NuA3 recognition and H3K14 acetylation

19 Dec 2025

Contributed by Lukas

️ Episode 233: Mechanistic basis of NuA3 recognition and H3K14 acetylation In this episode of PaperCast Base by Base, we explore Cryo-EM structures...

232: Lamin A/C steers fork restart via H3K9me3 and PARylation

18 Dec 2025

Contributed by Lukas

️Episode 232: Lamin A/C steers fork restart via H3K9me3 and PARylation In this episode of PaperCast Base by Base, we explore Nucleoplasmic Lamin A/C...

231: Transcription start sites as a germline mutational hotspot

17 Dec 2025

Contributed by Lukas

️Episode 231: Transcription start sites as a germline mutational hotspot In this episode of PaperCast Base by Base, we explore This study identifies...

230: MIDEAS Y654S hyperactivates MiDAC in a dominant neurodevelopmental syndrome

17 Dec 2025

Contributed by Lukas

️ Episode 230: MIDEAS Y654S hyperactivates MiDAC in a dominant neurodevelopmental syndrome In this episode of PaperCast Base by Base, we explore A ...

229: Inhibiting PCBP2 condensates in Alzheimer’s

15 Dec 2025

Contributed by Lukas

️ Episode 229: Inhibiting PCBP2 condensates in Alzheimer’s In this episode of PaperCast Base by Base, we explore Elevated PCBP2 forms liquid-like...

228: Two non-competing H3N2 stem antibodies reveal evolving antigenicity

14 Dec 2025

Contributed by Lukas

️ Episode 228: Two non-competing H3N2 stem antibodies reveal evolving antigenicity In this episode of PaperCast Base by Base, we explore Structural ...

227: 1q gain enables rescue of aneuploid hESCs during RPE differentiation

13 Dec 2025

Contributed by Lukas

️ Episode 227: 1q gain enables rescue of aneuploid hESCs during RPE differentiation In this episode of PaperCast Base by Base, we explore This stud...

226: FGF4 protects podocytes in diabetic kidney disease

12 Dec 2025

Contributed by Lukas

️ Episode 226: FGF4 protects podocytes in diabetic kidney disease In this episode of PaperCast Base by Base, we explore This study shows that podoc...

225: VRK-1 and BAF-1 release meiotic chromosomes

10 Dec 2025

Contributed by Lukas

️ Episode 225: VRK-1 and BAF-1 release meiotic chromosomes In this episode of PaperCast Base by Base, we explore VRK-1 phosphorylates BAF-1 to remov...

224: AntennAlive — wireless in-body sensing with engineered bacteria

10 Dec 2025

Contributed by Lukas

️ Episode 224: AntennAlive — wireless in-body sensing with engineered bacteria In this episode of PaperCast Base by Base, we explore A bio-hybrid,...

223: Torsion Regulates DNA Replication Stalling and Restart

09 Dec 2025

Contributed by Lukas

️ Episode 223: Torsion Regulates DNA Replication Stalling and Restart In this episode of PaperCast Base by Base, we explore New single-molecule angu...

222: snaR-A hijacks splicing to drive proliferation

08 Dec 2025

Contributed by Lukas

️ Episode 222: snaR-A hijacks splicing to drive proliferation In this episode of PaperCast Base by Base, we explore This episode examines how the ca...

221: Allele-resolved nanopore tour of the human placental methylome

07 Dec 2025

Contributed by Lukas

️ Episode 221: Allele-resolved nanopore tour of the human placental methylome In this episode of PaperCast Base by Base, we explore Using phased lon...

220: The AML cellular state space reveals NPM1 immune evasion subtypes

06 Dec 2025

Contributed by Lukas

️Episode 220: The AML cellular state space reveals NPM1 immune evasion subtypes In this episode of PaperCast Base by Base, we explore Single-cell an...

219: Multi-omic mapping of lipid dysregulation in Parkinson’s brain

05 Dec 2025

Contributed by Lukas

️Episode 219: Multi-omic mapping of lipid dysregulation in Parkinson’s brain In this episode of PaperCast Base by Base, we explore Targeted multi-...

218: SIM1 and the multi-ancestry genomics of erectile dysfunction

04 Dec 2025

Contributed by Lukas

️Episode 218: SIM1 and the multi-ancestry genomics of erectile dysfunction In this episode of PaperCast Base by Base, we explore A large multi-ance...

217: Multiscale triads of meiotic crossover patterning

03 Dec 2025

Contributed by Lukas

️Episode 217: Multiscale triads of meiotic crossover patterning In this episode of PaperCast Base by Base, we explore FFT and inverse-FFT analysis o...

216: 53BP1-RIF1 and DNA-PKcs: distinct interactions in chromosomal break repair

02 Dec 2025

Contributed by Lukas

️ Episode 216: 53BP1-RIF1 and DNA-PKcs: distinct interactions in chromosomal break repair In this episode of PaperCast Base by Base, we explore Thi...

215: Protein Set Transformer for high-diversity viromics

01 Dec 2025

Contributed by Lukas

️ Episode 215: Protein Set Transformer for high-diversity viromics In this episode of PaperCast Base by Base, we explore Protein Set Transformer (P...

214: PI(4,5)P2 Asymmetry Enables Rapid FGF2 Secretion

30 Nov 2025

Contributed by Lukas

️ Episode 214: PI(4,5)P2 Asymmetry Enables Rapid FGF2 Secretion In this episode of PaperCast Base by Base, we explore This study shows that an asymm...

213: BRAIN-MAGNET: a functional atlas for non-coding variants

29 Nov 2025

Contributed by Lukas

️ Episode 213: BRAIN-MAGNET: a functional atlas for non-coding variants In this episode of PaperCast Base by Base, we explore BRAIN-MAGNET couples ...

212: Zonal control of mutant β-catenin tumorigenesis

28 Nov 2025

Contributed by Lukas

️ Episode 212: Zonal control of mutant β-catenin tumorigenesis This study shows that hepatic zonation determines whether mutant β-catenin drives ...

211: Retention Elements in Cancer Cells

27 Nov 2025

Contributed by Lukas

️ Episode 211: Retention Elements in Cancer Cells In this episode of PaperCast Base by Base, we explore the discovery of genetic elements that prom...

210: Tumour-Reactive CD8 T Cell Clusters in Human Melanoma

26 Nov 2025

Contributed by Lukas

️ Episode 210: Tumour-Reactive CD8 T Cell Clusters in Human Melanoma In this episode of PaperCast Base by Base, we explore how tumour-reactive CD8 T...

209: PERT: Prime Editing tRNAs for Nonsense Mutations

25 Nov 2025

Contributed by Lukas

️ Episode 209: PERT: Prime Editing tRNAs for Nonsense Mutations In this episode of PaperCast Base by Base, we explore how prime editing can reprogr...

208: ZAK, Collided Ribosomes, and the Stress Switch

24 Nov 2025

Contributed by Lukas

️ Episode 208: ZAK, Collided Ribosomes, and the Stress Switch In this episode of PaperCast Base by Base, we explore how collided ribosomes activate...

207: Semantic Design of de novo Genes with Evo

24 Nov 2025

Contributed by Lukas

️ Episode 207: Semantic Design of de novo Genes with Evo In this episode of PaperCast Base by Base, we explore how a genomic language model called ...

206: Wild Birds and the North American H5N1 Epizootic

22 Nov 2025

Contributed by Lukas

️ Episode 206: Wild Birds and the North American H5N1 Epizootic In this episode of PaperCast Base by Base, we explore how wild migratory birds have ...

205: Ancient RNA Expression Profiles from the Woolly Mammoth

21 Nov 2025

Contributed by Lukas

️ Episode 205: Ancient RNA Expression Profiles from the Woolly Mammoth In this episode of PaperCast Base by Base, we explore how ancient RNA preser...

204: StealTHY CRISPR: Revealing Hidden Metastasis Regulators

20 Nov 2025

Contributed by Lukas

️ Episode 204: StealTHY CRISPR: Revealing Hidden Metastasis Regulators In this episode of PaperCast Base by Base, we explore how the StealTHY CRISP...

203: Divergent Evolutionary Dynamics of Benign and Malignant Tumors

19 Nov 2025

Contributed by Lukas

️ Episode 203: Divergent Evolutionary Dynamics of Benign and Malignant Tumors In this episode of PaperCast Base by Base, we explore how benign and m...

202: Stereo-seq V2: Spatial Total RNA Mapping in FFPE Tissues

19 Nov 2025

Contributed by Lukas

️ Episode 202: Stereo-seq V2: Spatial Total RNA Mapping in FFPE Tissues In this episode of PaperCast Base by Base, we explore how Stereo-seq V2 del...

201: Sex, Smoking, and Somatic Selection in the Bladder

17 Nov 2025

Contributed by Lukas

️ Episode 201: Sex, Smoking, and Somatic Selection in the Bladder In this episode of PaperCast Base by Base, we explore how ultradeep duplex DNA seq...

200: Sperm Sequencing Reveals Extensive Positive Selection in the Male Germline

16 Nov 2025

Contributed by Lukas

️ Episode 200: Sperm Sequencing Reveals Extensive Positive Selection in the Male Germline In this episode of PaperCast Base by Base, we explore how ...

199: PLD4 Deficiency and Lupus: When Nuclease Failure Ignites Autoimmunity

15 Nov 2025

Contributed by Lukas

️ Episode 199: PLD4 Deficiency and Lupus: When Nuclease Failure Ignites Autoimmunity In this episode of PaperCast Base by Base, we explore how loss...

198: Mechanical Confinement and the Shape-Shifting Life of Melanoma Cells

14 Nov 2025

Contributed by Lukas

️ Episode 198: Mechanical Confinement and the Shape-Shifting Life of Melanoma Cells In this episode of PaperCast Base by Base, we explore how physi...

197: Somatic Mutation and Selection at Population Scale

13 Nov 2025

Contributed by Lukas

️ Episode 197: Somatic Mutation and Selection at Population Scale In this episode of PaperCast Base by Base, we explore how ultra-accurate NanoSeq d...

196: Impact of Chromatin Accessibility QTLs Across Immune Contexts

12 Nov 2025

Contributed by Lukas

️ Episode 196: Impact of Chromatin Accessibility QTLs Across Immune Contexts In this episode of PaperCast Base by Base, we explore how single-cell ...

195: Tiny Shields: Lymphoid Microglia in Alzheimer’s Disease

11 Nov 2025

Contributed by Lukas

️ Episode 195: Tiny Shields: Lymphoid Microglia in Alzheimer’s Disease In this episode of PaperCast Base by Base, we explore how a subset of bra...

194: Bayesian History of Science: Watson and Crick and the Structure of DNA

10 Nov 2025

Contributed by Lukas

️ Episode 194: Bayesian History of Science: Watson and Crick and the Structure of DNA In this episode of PaperCast Base by Base, we explore how Baye...

193: SARM1, DNA, and the Death Signal

09 Nov 2025

Contributed by Lukas

️Episode 193: SARM1, DNA, and the Death Signal In this episode of PaperCast Base by Base, we explore how the axon-degenerating enzyme SARM1 acts as ...

192: At Base-Pair Resolution: Chromatin’s Cis-Regulatory Conversations

08 Nov 2025

Contributed by Lukas

️Episode 192: At Base-Pair Resolution: Chromatin’s Cis-Regulatory Conversations In this episode of PaperCast Base by Base, we explore how base-pai...

191: CATphishing: Synthetic Learning as an Alternative to Federated Learning in MRI

07 Nov 2025

Contributed by Lukas

️ Episode 191: CATphishing: Synthetic Learning as an Alternative to Federated Learning in MRI In this episode of PaperCast Base by Base, we explore...

190: Single-Cell Networks Reveal Cell Type–Specific Mechanisms in Type 2 Diabetes

06 Nov 2025

Contributed by Lukas

️ Episode 190: Single-Cell Networks Reveal Cell Type–Specific Mechanisms in Type 2 Diabetes In this episode of PaperCast Base by Base, we explore...

189: DNA methylation patterns facilitate tracing the origin of neuroendocrine neoplasms

05 Nov 2025

Contributed by Lukas

️ Episode 189: DNA methylation patterns facilitate tracing the origin of neuroendocrine neoplasms In this episode of PaperCast Base by Base, we exp...

188: Proteomics + Machine Learning for Lyme Neuroborreliosis Diagnosis

04 Nov 2025

Contributed by Lukas

️ Episode 188: Proteomics + Machine Learning for Lyme Neuroborreliosis Diagnosis In this episode of PaperCast Base by Base, we explore how large‑...

187: Gapped PARP + Tumor‑Targeted TOP1 in Advanced Tumors

03 Nov 2025

Contributed by Lukas

️ Episode 187: Gapped PARP + Tumor‑Targeted TOP1 in Advanced Tumors In this episode of PaperCast Base by Base, we explore a phase I dose‑escala...

186: TNFα–TGFβ Axis Disrupts Nasal Epithelium in Post‑COVID Syndrome

02 Nov 2025

Contributed by Lukas

️ Episode 186: TNFα–TGFβ Axis Disrupts Nasal Epithelium in Post‑COVID Syndrome In this episode of PaperCast Base by Base, we explore a single...

185: Altered Milk Tryptophan in Women Living with HIV

01 Nov 2025

Contributed by Lukas

️ Episode 185: Altered Milk Tryptophan in Women Living with HIV In this episode of PaperCast Base by Base, we explore a longitudinal metabolomics s...

184: High-Accuracy Multiethnic XGBoost for Skin Cancer Identification

31 Oct 2025

Contributed by Lukas

️ Episode 184: High-Accuracy Multiethnic XGBoost for Skin Cancer Identification In this episode of PaperCast Base by Base, we explore a large-scale...

183: The Genetic Lottery Goes to School: Better Schools Compensate for Genetic Differences

30 Oct 2025

Contributed by Lukas

️ Episode 183: The Genetic Lottery Goes to School: Better Schools Compensate for Genetic Differences In this episode of PaperCast Base by Base, we ...

182: Genotypic, Functional, and Phenotypic Characterization in CTNNB1 Neurodevelopmental Syndrome

29 Oct 2025

Contributed by Lukas

️ Episode 182: Genotypic, Functional, and Phenotypic Characterization in CTNNB1 Neurodevelopmental Syndrome In this episode of PaperCast Base by Ba...

181: Creatine Transporter SLC6A8: Conservation and Variant Impact

28 Oct 2025

Contributed by Lukas

️ Episode 181: Creatine Transporter SLC6A8: Conservation and Variant Impact In this episode of PaperCast Base by Base, we explore how the creatine ...