Base by Base

133: Culture-Independent Meta‑Pangenomics Reveals Gut Genome Links to Child Growth

10 Sep 2025

Contributed by Lukas

️ Episode 133: Culture-Independent Meta‑Pangenomics Reveals Gut Genome Links to Child Growth In this episode of PaperCast Base by Base, we explor...

132: Tumor transcriptome classifiers predict treatment sensitivity in advanced prostate cancer

09 Sep 2025

Contributed by Lukas

️ Episode 132: Tumor transcriptome classifiers predict treatment sensitivity in advanced prostate cancer In this episode of PaperCast Base by Base,...

131: pBI143: The Human Gut’s Hidden Heavyweight

08 Sep 2025

Contributed by Lukas

️ Episode 131: pBI143: The Human Gut’s Hidden Heavyweight In this episode of PaperCast Base by Base, we explore how a tiny 2.7 kb cryptic plasmid...

130: Combining Evidence from Human Genetic and Functional Screens to Identify Pathways Altering Obesity and Fat Distribution

07 Sep 2025

Contributed by Lukas

️ Episode 130: Combining Evidence from Human Genetic and Functional Screens to Identify Pathways Altering Obesity and Fat Distribution In this epis...

129: Structural variation and diversification of the NPIP gene family from the human pangenome

06 Sep 2025

Contributed by Lukas

️ Episode 129: Structural variation and diversification of the NPIP gene family from the human pangenome In this episode of PaperCast Base by Base,...

128: LINE‑1 Promoters Orchestrate Early Human Brain Development

05 Sep 2025

Contributed by Lukas

️ Episode 128: LINE‑1 Promoters Orchestrate Early Human Brain Development In this episode of PaperCast Base by Base, we explore how evolutionaril...

127: In silico generation of synthetic cancer genomes using generative AI

04 Sep 2025

Contributed by Lukas

️ Episode 127: In silico generation of synthetic cancer genomes using generative AI In this episode of PaperCast Base by Base, we explore OncoGAN, ...

126: Molecular and developmental deficits in Smith-Magenis syndrome human stem cell-derived cortical neural models

03 Sep 2025

Contributed by Lukas

️ Episode 126: Molecular and developmental deficits in Smith-Magenis syndrome human stem cell-derived cortical neural models In this episode of Pap...

125: Tackling a disease on a global scale, the Global Parkinson’s Genetics Program, GP2: A new generation of opportunities

02 Sep 2025

Contributed by Lukas

️ Episode 125: Tackling a disease on a global scale, the Global Parkinson’s Genetics Program, GP2: A new generation of opportunities In this episo...

124: Exploring the Omnigenic Architecture of Selected Complex Traits

01 Sep 2025

Contributed by Lukas

️ Episode 124: Exploring the Omnigenic Architecture of Selected Complex Traits In this episode of PaperCast Base by Base, we explore how researcher...

123: Dominant‑Negative ATP5F1A Variants Uncouple Complex V and Drive Neurological Disease

31 Aug 2025

Contributed by Lukas

️ Episode 123: Dominant‑Negative ATP5F1A Variants Uncouple Complex V and Drive Neurological Disease In this episode of PaperCast Base by Base, we...

122: Patient Stratification Reveals the Molecular Basis of Disease Co-Occurrences

30 Aug 2025

Contributed by Lukas

️ Episode 122: Patient Stratification Reveals the Molecular Basis of Disease Co-Occurrences In this episode of PaperCast Base by Base, we explore a...

121: G-quadruplexes as a Source of Vulnerability in BRCA2-deficient Granule Cell Progenitors and Medulloblastoma

29 Aug 2025

Contributed by Lukas

️ Episode 121: G-quadruplexes as a Source of Vulnerability in BRCA2-deficient Granule Cell Progenitors and Medulloblastoma In this episode of Paper...

120: Rare BMAL1 Variants Link the Circadian Clock to Neurodevelopment

28 Aug 2025

Contributed by Lukas

️Episode 120: Rare BMAL1 Variants Link the Circadian Clock to Neurodevelopment In this episode of PaperCast Base by Base, we explore how ultrarare h...

119: G‑Quadruplex Stabilization Triggers Pericentromeric DNA Breaks in B Cells

27 Aug 2025

Contributed by Lukas

️ Episode 119: G‑Quadruplex Stabilization Triggers Pericentromeric DNA Breaks in B Cells In this episode of PaperCast Base by Base, we explore ho...

118: Cancer cells subvert the primate-specific KRAB zinc finger protein ZNF93 to control APOBEC3B

26 Aug 2025

Contributed by Lukas

️ Episode 118: Cancer cells subvert the primate-specific KRAB zinc finger protein ZNF93 to control APOBEC3B In this episode of PaperCast Base by Ba...

117: Pol III–linked polyadenylation fuels SINE RNA accumulation during infection

25 Aug 2025

Contributed by Lukas

️ Episode 117: Pol III–linked polyadenylation fuels SINE RNA accumulation during infection In this episode of PaperCast Base by Base, we explore ...

116: Cell Type–Specific Purifying Selection of Synonymous mtDNA Variation

24 Aug 2025

Contributed by Lukas

️ Episode 116: Cell Type–Specific Purifying Selection of Synonymous mtDNA Variation In this episode of PaperCast Base by Base, we explore how a s...

115: A Transcriptomic, Proteomic, and Functional Genetic Atlas Dissects Neurofibromin Function in the Peripheral Nervous System

24 Aug 2025

Contributed by Lukas

Episode 115: A Transcriptomic, Proteomic, and Functional Genetic Atlas Dissects Neurofibromin Function in the Peripheral Nervous System In this episod...

114: One-hour extraction-free loop-mediated isothermal amplification HPV DNA assay for point-of-care testing in Maputo, Mozambique

22 Aug 2025

Contributed by Lukas

️ Episode 114: One-hour extraction-free loop-mediated isothermal amplification HPV DNA assay for point-of-care testing in Maputo, Mozambique In thi...

113: Joint, Multifaceted Genomic Analysis Enables Diagnosis of Ultra-Rare Monogenic Presentations

21 Aug 2025

Contributed by Lukas

️ Episode 113: Joint, Multifaceted Genomic Analysis Enables Diagnosis of Ultra-Rare Monogenic Presentations In this episode of PaperCast Base by Bas...

112: Local Genetic Sex Differences in Quantitative Traits

20 Aug 2025

Contributed by Lukas

️ Episode 112: Local Genetic Sex Differences in Quantitative Traits In this episode of PaperCast Base by Base, we explore how genetic differences b...

111: A Multimodal Dataset for Precision Oncology in Head and Neck Cancer

19 Aug 2025

Contributed by Lukas

️ Episode 111: A Multimodal Dataset for Precision Oncology in Head and Neck Cancer In this episode of PaperCast Base by Base, we explore the creati...

110: Whole-exome sequencing identifies new schizophrenia risk genes

18 Aug 2025

Contributed by Lukas

️ Episode 110: Whole-exome sequencing identifies new schizophrenia risk genes In this episode of PaperCast Base by Base, we explore a landmark whol...

109: Autocrine Interferon Poisoning: ADAR1–BRCA Synthetic Lethality

17 Aug 2025

Contributed by Lukas

️ Episode 109: Autocrine Interferon Poisoning: ADAR1–BRCA Synthetic Lethality In this episode of PaperCast Base by Base, we explore how loss of t...

108: Epigenome Editing Reverses HBG Silencing

16 Aug 2025

Contributed by Lukas

️ Episode 108: Epigenome Editing Reverses HBG Silencing In this episode of PaperCast Base by Base, we explore how targeted removal of CpG methylati...

107: Genome-wide Association Study Reveals Genetic Links to Pulpal and Apical Diseases

15 Aug 2025

Contributed by Lukas

Episode 107: Genome-wide Association Study Reveals Genetic Links to Pulpal and Apical Diseases In this episode of PaperCast Base by Base, we explore a...

106: Decoding Brain Maps for Pharmacotranscriptomics

14 Aug 2025

Contributed by Lukas

️ Episode 106: Decoding Brain Maps for Pharmacotranscriptomics In this episode of PaperCast Base by Base, we explore a Nature Communications study,...

105: Genome-level Selection as a Universal Marker of Cancer Therapy Resistance

13 Aug 2025

Contributed by Lukas

️ Episode 105: Genome-level Selection as a Universal Marker of Cancer Therapy Resistance In this episode of PaperCast Base by Base, we explore grou...

104: Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation

12 Aug 2025

Contributed by Lukas

Episode 104: Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation In this episode of PaperCast B...

103: Genome Sequencing Forecasts Outcomes After Congenital Cardiac Surgery

11 Aug 2025

Contributed by Lukas

️ Episode 103: Genome Sequencing Forecasts Outcomes After Congenital Cardiac Surgery In this episode of PaperCast Base by Base, we explore how larg...

102: Clinical Impact of Pharmacogenetic Risk Variants in a Large Chinese Cohort

10 Aug 2025

Contributed by Lukas

Episode 102: Clinical Impact of Pharmacogenetic Risk Variants in a Large Chinese Cohort In this episode of PaperCast Base by Base, we explore how larg...

101: JAK2 Inhibition Selects RAS-Mutant Clones in Myelofibrosis

09 Aug 2025

Contributed by Lukas

️Episode 101: JAK2 Inhibition Selects RAS-Mutant Clones in Myelofibrosis In this episode of PaperCast Base by Base, we explore how JAK2 inhibition w...

️ 100: Epigenomic Diagnosis and Prognosis of Acute Myeloid Leukemia

08 Aug 2025

Contributed by Lukas

️ Episode 100: Epigenomic Diagnosis and Prognosis of Acute Myeloid Leukemia In this episode of PaperCast Base by Base, we explore a groundbreaking s...

️ 99: NXT2: A Testis-Specific RNA Export Factor Essential for Spermatogenesis

07 Aug 2025

Contributed by Lukas

️ Episode 99: NXT2: A Testis-Specific RNA Export Factor Essential for Spermatogenesis In this episode of PaperCast Base by Base, we explore how the ...

️ 98: Cell Marker Accordion: Interpretable Single-Cell and Spatial Omics Annotation in Health and Disease

06 Aug 2025

Contributed by Lukas

️ Episode 98: Cell Marker Accordion: Interpretable Single-Cell and Spatial Omics Annotation in Health and Disease In this episode of PaperCast Base ...

️ 97: Pancreatic Cancer Genomics: Insights from the COMPASS Trial

05 Aug 2025

Contributed by Lukas

️ Episode 97: Pancreatic Cancer Genomics: Insights from the COMPASS Trial In this episode of PaperCast Base by Base, we explore how integrated whole...

️ 96: Early Cerebrospinal Fluid Proteomic Changes in Down Syndrome and Alzheimer’s Disease

04 Aug 2025

Contributed by Lukas

️ Episode 96: Early Cerebrospinal Fluid Proteomic Changes in Down Syndrome and Alzheimer’s Disease In this episode of PaperCast Base by Base, we e...

️ 95: Mitochondria on the Move: Biotechnological Strategies for Transfer and Transplantation

03 Aug 2025

Contributed by Lukas

️ Episode 95: Mitochondria on the Move: Biotechnological Strategies for Transfer and Transplantation In this episode of PaperCast Base by Base, we e...

️ 94: Intraindividual Epigenetic Heterogeneity in Advanced Prostate Cancer

02 Aug 2025

Contributed by Lukas

️ Episode 94: Intraindividual Epigenetic Heterogeneity in Advanced Prostate Cancer In this episode of PaperCast Base by Base, we explore how integra...

️ 93: Neuroinvasive and Pulmonary Virulence of H5N1 Clade 2.3.4.4b Genotype B3.13

01 Aug 2025

Contributed by Lukas

️ Episode 93: Neuroinvasive and Pulmonary Virulence of H5N1 Clade 2.3.4.4b Genotype B3.13 In this episode of PaperCast Base by Base, we explore how ...

️ 92: Genetic Loss of CFHR5 Function Protects Against Age-Related Macular Degeneration

31 Jul 2025

Contributed by Lukas

️ Episode 92: Genetic Loss of CFHR5 Function Protects Against Age-Related Macular Degeneration In this episode of PaperCast Base by Base, we explore...

️ 91: Genome-wide Association of Plasma N-Glycome Reveals Links to Liver Disease and Anti-Inflammatory Proteins

30 Jul 2025

Contributed by Lukas

️ Episode 91: Genome-wide Association of Plasma N-Glycome Reveals Links to Liver Disease and Anti-Inflammatory Proteins In this episode of PaperCast...

️ 90: Variable and Interactive Effects of Sex, APOE ε4 and TREM2 on Tau Deposition

29 Jul 2025

Contributed by Lukas

️ Episode 90: Variable and Interactive Effects of Sex, APOE ε4 and TREM2 on Tau Deposition In this episode of PaperCast Base by Base, we explore ho...

️ 89: Decoding the Genetics of Smell: Sex-Specific Variants in Olfactory Identification

28 Jul 2025

Contributed by Lukas

️ Episode 89: Decoding the Genetics of Smell: Sex-Specific Variants in Olfactory Identification In this episode of PaperCast Base by Base, we explor...

️ 88: Stable Heritability of Type 1 Diabetes Over Three Decades in Sweden

27 Jul 2025

Contributed by Lukas

️ Episode 88: Stable Heritability of Type 1 Diabetes Over Three Decades in Sweden In this episode of PaperCast Base by Base, we explore a Swedish na...

️ 87: Circulating cfDNA Methylation Reveals Allograft Injury Sources after Liver Transplant

26 Jul 2025

Contributed by Lukas

️ Episode 87: Circulating cfDNA Methylation Reveals Allograft Injury Sources after Liver Transplant In this episode of PaperCast Base by Base, we ex...

️ 86: Variable Penetrance in Monogenic Traits — How Genetic Background Modulates Disease Severity

25 Jul 2025

Contributed by Lukas

️ Episode 86: Variable Penetrance in Monogenic Traits — How Genetic Background Modulates Disease Severity In this episode of PaperCast Base by Bas...

️ 85: Genomic landscape of virus-associated cancers

24 Jul 2025

Contributed by Lukas

️ Episode 85: Genomic landscape of virus-associated cancers In this episode of PaperCast Base by Base, we explore the comparative genomic analysis o...

️ 84: Variants in NR6A1 cause a novel oculo-vertebral-renal syndrome

23 Jul 2025

Contributed by Lukas

️ Episode 84: Variants in NR6A1 cause a novel oculo-vertebral-renal syndrome In this episode of PaperCast Base by Base, we explore the discovery of ...

️ 83: Single-cell Analysis of dup15q Syndrome Illuminates Autism Mechanisms

22 Jul 2025

Contributed by Lukas

️ Episode 83: Single-cell Analysis of dup15q Syndrome Illuminates Autism Mechanisms In this episode of PaperCast Base by Base, we explore how single...

️ 82: JAK2 Inhibition Drives RAS Pathway Mutant Clonal Selection in Myeloproliferative Neoplasms

21 Jul 2025

Contributed by Lukas

️ Episode 82: JAK2 Inhibition Drives RAS Pathway Mutant Clonal Selection in Myeloproliferative Neoplasms In this episode of PaperCast Base by Base, ...

️ 81: Clinical Impact of Pharmacogenetic Risk Variants in a Large Chinese Cohort

20 Jul 2025

Contributed by Lukas

️ Episode 81: Clinical Impact of Pharmacogenetic Risk Variants in a Large Chinese Cohort In this episode of PaperCast Base by Base, we explore a ret...

️ 80: Genomic Forecasting of Postoperative Outcomes in Congenital Cardiac Surgery

19 Jul 2025

Contributed by Lukas

️ Episode 80: Genomic Forecasting of Postoperative Outcomes in Congenital Cardiac Surgery In this episode of PaperCast Base by Base, we explore the ...

️ 79: Cross-Population GWAS and Proteomic Insights in Atrial Fibrillation

18 Jul 2025

Contributed by Lukas

️ Episode 79: Cross-Population GWAS and Proteomic Insights in Atrial Fibrillation In this episode of PaperCast Base by Base, we explore a cross-popu...

️ 78: Interactions between TTYH2 and APOE Facilitate Endosomal Lipid Transfer

17 Jul 2025

Contributed by Lukas

️ Episode 78: Interactions between TTYH2 and APOE Facilitate Endosomal Lipid Transfer In this episode of PaperCast Base by Base, we explore the disc...

️ 77: Range Extender: Unlocking Long-Distance Enhancer Activity

16 Jul 2025

Contributed by Lukas

️ Episode 77: Range Extender: Unlocking Long-Distance Enhancer Activity In this episode of PaperCast Base by Base, we explore the discovery and func...

️ 76: Whole-genome Ancestry of an Old Kingdom Egyptian

15 Jul 2025

Contributed by Lukas

️ Episode 76: Whole-genome Ancestry of an Old Kingdom Egyptian In this episode of PaperCast Base by Base, we explore the first 2× coverage whole-ge...

️ 75: Metabolic Shaping of Enzyme Structures Over 400 Million Years

14 Jul 2025

Contributed by Lukas

️ Episode 75: Metabolic Shaping of Enzyme Structures Over 400 Million Years In this episode of PaperCast Base by Base, we explore a large-scale stud...

️ 74: Benchmarking T Cell Receptor–Epitope Predictors with ePytope-TCR

13 Jul 2025

Contributed by Lukas

️ Episode 74: Benchmarking T Cell Receptor–Epitope Predictors with ePytope-TCR In this episode of PaperCast Base by Base, we explore a unified com...

️ 73: Assessing Family History in Dementia Genetics: Enhancing Diagnostic Yield

12 Jul 2025

Contributed by Lukas

️ Episode 73: Assessing Family History in Dementia Genetics: Enhancing Diagnostic Yield In this episode of PaperCast Base by Base, we explore a stud...

️ 72: The POC5 Syndrome — A Ciliopathy Linking Retina, Muscles and Metabolism

11 Jul 2025

Contributed by Lukas

️ Episode 72: The POC5 Syndrome — A Ciliopathy Linking Retina, Muscles and Metabolism In this episode of Base by Base, we explore a multi-institut...

️ 71: ELFN1 Deficiency Disorder — Mechanistic Basis and Phenotypic Spectrum of a Neurodevelopmental Disorder with Epilepsy

10 Jul 2025

Contributed by Lukas

️ Episode 71: ELFN1 Deficiency Disorder — Mechanistic Basis and Phenotypic Spectrum of a Neurodevelopmental Disorder with Epilepsy In this episode...

️ 70: Scalable Screening of Ternary-Code DNA Methylation Dynamics Associated with Human Traits

09 Jul 2025

Contributed by Lukas

️ Episode 70: Scalable Screening of Ternary-Code DNA Methylation Dynamics Associated with Human Traits In this episode of Base por Base, we delve in...

️ 69: Synthetic Dosage Lethality of PLK1 — Targetable Vulnerabilities in PLK1-Overexpressing Cancers

08 Jul 2025

Contributed by Lukas

️ Episode 69: Synthetic Dosage Lethality of PLK1 — Targetable Vulnerabilities in PLK1-Overexpressing Cancers In this episode of Base por Base, we ...

️ 68: Indels Empower Antiviral Proteins to Achieve Functional Novelty Beyond Missense Mutations

07 Jul 2025

Contributed by Lukas

️ Episode 68: Indels Empower Antiviral Proteins to Achieve Functional Novelty Beyond Missense Mutations In this episode of Base by Base, we dive int...

️ 67: Smarter Signals — How Multimodal AI Boosts Genetic Prediction of Heart Disease

06 Jul 2025

Contributed by Lukas

️ Episode 67: Smarter Signals — How Multimodal AI Boosts Genetic Prediction of Heart Disease In this episode of Base por Base, we delve into a maj...

️ 66: Mainstreaming Clinical Genetic Testing — A Conceptual Framework

05 Jul 2025

Contributed by Lukas

️ Episode 66: Mainstreaming Clinical Genetic Testing — A Conceptual Framework In this episode of Base por Base, we delve into the consensus-based ...

️ 65: Uncovering Hidden Splice Defects — Genome Sequencing and Group-Enrichment in Marfan Syndrome

04 Jul 2025

Contributed by Lukas

️ Episode 65: Uncovering Hidden Splice Defects — Genome Sequencing and Group-Enrichment in Marfan Syndrome In this episode of Base por Base, we de...

️ 64: Pisces — A Multi-Modal Framework for Predicting Drug Combination Synergy

03 Jul 2025

Contributed by Lukas

️ Episode 64: Pisces — A Multi-Modal Framework for Predicting Drug Combination Synergy In this episode of Base by Base, we delve into a groundbrea...

️ 63: Sampling Scale Matters — A Spatial Model for Rare Variant Discovery in Biobank-Scale Datasets

02 Jul 2025

Contributed by Lukas

️ Episode 63: Sampling Scale Matters — A Spatial Model for Rare Variant Discovery in Biobank-Scale Datasets In this episode of Base by Base, we de...

️ 62: Breaking Resistance — How BRCA2-Deficient Tumors Escape PARP Inhibition Without Reversion Mutations

01 Jul 2025

Contributed by Lukas

️ Episode 62: Breaking Resistance — How BRCA2-Deficient Tumors Escape PARP Inhibition Without Reversion Mutations In this episode of Base by Base,...

️ 61: Monkeypox on the Frontline — Developing Brazil’s First qPCR Diagnostic Assay

30 Jun 2025

Contributed by Lukas

️ Episode 61: Monkeypox on the Frontline — Developing Brazil’s First qPCR Diagnostic Assay In this episode of Base by Base, we trace the rapid d...

️ 60: Epi-PRS — A New Frontier in Polygenic Risk Prediction with Epigenomic Features

30 Jun 2025

Contributed by Lukas

️ Episode 60: Epi-PRS — A New Frontier in Polygenic Risk Prediction with Epigenomic Features In this episode of Base by Base, we explore a breakth...

️ 59: Building Trust — Redefining Participant and Community Engagement in Cancer Genomics

29 Jun 2025

Contributed by Lukas

️ Episode 59: Building Trust — Redefining Participant and Community Engagement in Cancer Genomics In this episode of Base by Base, we dive into a ...

️ 58: Aneuploid Cells and Cellular Battles — How Cell Interactions Shape Genome Integrity

28 Jun 2025

Contributed by Lukas

️ Episode 58: Aneuploid Cells and Cellular Battles — How Cell Interactions Shape Genome Integrity In this episode of Base by Base, we explore a gr...

️ 57: Low Uptake of Genetic Testing in Medicaid-Enrolled Children with ASD and Intellectual Disability

27 Jun 2025

Contributed by Lukas

️ Episode 57: Low Uptake of Genetic Testing in Medicaid-Enrolled Children with ASD and Intellectual Disability In this episode of Base by Base, we d...

️ 56: Neuronal Immunoproteasome — A Metabolic Trigger for Ferroptotic Neurodegeneration in Multiple Sclerosis

26 Jun 2025

Contributed by Lukas

️ Episode 56: Neuronal Immunoproteasome — A Metabolic Trigger for Ferroptotic Neurodegeneration in Multiple Sclerosis In this episode of Base by B...

️ 55: Denisovan DNA in Dental Calculus — Linking Morphology and Genetics in a 146,000-Year-Old Hominin

25 Jun 2025

Contributed by Lukas

️ Episode 55: Denisovan DNA in Dental Calculus — Linking Morphology and Genetics in a 146,000-Year-Old Hominin In this episode of Base by Base, we...

️ 54: Temporal Immune Landscapes — A Multi-Omic Lens on COVID-19 in End-Stage Kidney Disease

24 Jun 2025

Contributed by Lukas

️ Episode 54: Temporal Immune Landscapes — A Multi-Omic Lens on COVID-19 in End-Stage Kidney Disease In this new Base by Base episode we unpack a ...

️ 53: Weighing the Evidence — A Systematic Review of Polygenic Risk Score Economic Evaluations

23 Jun 2025

Contributed by Lukas

️ Episode 53: Weighing the Evidence — A Systematic Review of Polygenic Risk Score Economic Evaluations In this episode of Base by Base, we explore...

️ 52: Human Genetic Variation Reveals FCRL3 as a Lymphocyte Receptor for Yersinia pestis

22 Jun 2025

Contributed by Lukas

️ Episode 52: Human Genetic Variation Reveals FCRL3 as a Lymphocyte Receptor for Yersinia pestis In this episode of Base by Base, we dive into a cel...

️ 51: Diagnosing the Undiagnosed — A Phenotype-Driven Pipeline for Mitochondrial DNA Discovery

21 Jun 2025

Contributed by Lukas

️ Episode 51: Diagnosing the Undiagnosed — A Phenotype-Driven Pipeline for Mitochondrial DNA Discovery In this episode of Base by Base, we dive in...

️ 50: The Microbiome for Clinicians — Bridging Research and Practice

19 Jun 2025

Contributed by Lukas

️ Episode 50: The Microbiome for Clinicians — Bridging Research and Practice In this episode of Base by Base, we explore a Perspective article by ...

️ 49: Chitin as a Reservoir for Horizontal Gene Transfer — Environmental DNA Adsorption and Natural Transformation in Vibrio cholerae

18 Jun 2025

Contributed by Lukas

️ Episode 49: Chitin as a Reservoir for Horizontal Gene Transfer — Environmental DNA Adsorption and Natural Transformation in Vibrio cholerae In t...

️ 48: Mainstreaming Genetic Testing — A Conceptual Framework for Expanding Genomic Medicine

16 Jun 2025

Contributed by Lukas

️ Episode 48: Mainstreaming Genetic Testing — A Conceptual Framework for Expanding Genomic Medicine In this episode of Base by Base, we explore an...

️ 47: Selectivity and Promiscuity — Decoding the Human Chemokine-GPCR Network

16 Jun 2025

Contributed by Lukas

️ Episode 47: Selectivity and Promiscuity — Decoding the Human Chemokine-GPCR Network In this episode of Base by Base, we explore a systems-level ...

️ 46: Pan-Epitranscriptomic Control — How tRNA and m6A Interact to Regulate mRNA Decay

14 Jun 2025

Contributed by Lukas

️ Episode 46: Pan-Epitranscriptomic Control — How tRNA and m6A Interact to Regulate mRNA Decay In this episode of Base by Base, we delve into a la...

️ 45: Probing Nucleolar Mechanics — RNA-Dependent Viscoelasticity of Nucleolar Subcompartments

12 Jun 2025

Contributed by Lukas

️ Episode 45: Probing Nucleolar Mechanics — RNA-Dependent Viscoelasticity of Nucleolar Subcompartments In this episode of Base por Base, we delve ...

️ 44: Proofreading Precision — Unveiling the Cryo-EM Mechanism of Human DNA Polymerase ε Holoenzyme

12 Jun 2025

Contributed by Lukas

️ Episode 44: Proofreading Precision — Unveiling the Cryo-EM Mechanism of Human DNA Polymerase ε Holoenzyme In this episode of Base per Base, we ...

️ 43: Personalized Molecular Signatures of Insulin Resistance and Type 2 Diabetes

11 Jun 2025

Contributed by Lukas

️ Episode 43: Personalized Molecular Signatures of Insulin Resistance and Type 2 Diabetes In this episode of Base by Base, we explore the groundbrea...

️ 42: Amino Acids Catalyse RNA Formation — Unlocking Prebiotic Cross-Catalysis

11 Jun 2025

Contributed by Lukas

️ Episode 42: Amino Acids Catalyse RNA Formation — Unlocking Prebiotic Cross-Catalysis In this episode of Base por Base, we delve into the groundb...

️ 41: Public Preferences for Genomic Newborn Screening in Australia — Insights from Discrete Choice Experiments

10 Jun 2025

Contributed by Lukas

️ Episode 41: Public Preferences for Genomic Newborn Screening in Australia — Insights from Discrete Choice Experiments In this episode of Base by...

️ 40: Lysosomal Proton Leak — Uncovering SLC7A11’s Role as an Unconventional H⁺ Transit Pathway

09 Jun 2025

Contributed by Lukas

️ Episode 40: Lysosomal Proton Leak — Uncovering SLC7A11’s Role as an Unconventional H⁺ Transit Pathway In this episode of Base by Base, we de...

️ 39: Whole-Genome Polygenic Score Inference — Fast and Memory-Efficient Algorithms for Scalable PRS

07 Jun 2025

Contributed by Lukas

️ Episode 39: Whole-Genome Polygenic Score Inference — Fast and Memory-Efficient Algorithms for Scalable PRS In this episode of Base by Base, we d...

️ 38: Viral Journeys — Tracing the Ancestral Bat Origins of SARS-CoV and SARS-CoV-2

07 Jun 2025

Contributed by Lukas

️ Episode 38: The Recency and Geographical Origins of Bat Viruses Ancestral to SARS-CoV and SARS-CoV-2 In this episode of Base by Base, we delve int...

️ 37: Proteomic Clues — Prioritizing Functional Missense Variants with Chemoproteomics

06 Jun 2025

Contributed by Lukas

️ Episode 37: Proteomic Clues — Prioritizing Functional Missense Variants with Chemoproteomics In this episode of Base by Base, we highlight a new...

️ 36: Bi-allelic POPDC2 Variants: A Novel Autosomal Recessive Cardiac Syndrome

06 Jun 2025

Contributed by Lukas

️ Episode 36: Bi-allelic POPDC2 Variants: A Novel Autosomal Recessive Cardiac Syndrome In this episode of Base by Base, we discuss a groundbreaking ...

️ 35: Tracing the Evolutionary History of CCR5Δ32 — Insights from Ancient and Modern Genomes

06 Jun 2025

Contributed by Lukas

️ Episode 35: Tracing the Evolutionary History of CCR5Δ32 — Insights from Ancient and Modern Genomes In this episode of Base by Base, we explore ...

️ 34: Enzyme Replacement Therapy in Homocystinuria — Safety and Efficacy of Pegtibatinase in the Phase 1/2 COMPOSE Trial

06 Jun 2025

Contributed by Lukas

️ Episode 34: Enzyme Replacement Therapy in Homocystinuria — Safety and Efficacy of Pegtibatinase in the Phase 1/2 COMPOSE Trial In this episode o...