Base by Base
Episodes
180: Leveraging Global Genetics Resources for Equitable Polygenic Prediction
27 Oct 2025
Contributed by Lukas
️ Episode 180: Leveraging Global Genetics Resources for Equitable Polygenic Prediction In this episode of PaperCast Base by Base, we explore how mu...
179: Mosaicism for Autosomal Trisomies: Maternal Age, UPD, and Reproductive History in 1,266 Cases
26 Oct 2025
Contributed by Lukas
️ Episode 179: Mosaicism for Autosomal Trisomies: Maternal Age, UPD, and Reproductive History in 1,266 Cases In this episode of PaperCast Base by Ba...
178: TP53 Reduced Penetrance: Predictive Features and Clinical Implications
25 Oct 2025
Contributed by Lukas
️ Episode 178: TP53 Reduced Penetrance: Predictive Features and Clinical Implications In this episode of PaperCast Base by Base, we explore how a l...
177: Biallelic MCM8/MCM9 Variants: From Hypogonadism to Cancer Predisposition
24 Oct 2025
Contributed by Lukas
️ Episode 177: Biallelic MCM8/MCM9 Variants: From Hypogonadism to Cancer Predisposition In this episode of PaperCast Base by Base, we explore a mul...
176: FAHD1 and the Pyruvate-Driven Evolution of Hepatocellular Carcinoma
23 Oct 2025
Contributed by Lukas
️ Episode 176: FAHD1 and the Pyruvate-Driven Evolution of Hepatocellular Carcinoma In this episode of PaperCast Base by Base, we explore how multi-...
175: Predictive Prioritization of Pancreatic Enhancers Linked to Disease Risk
22 Oct 2025
Contributed by Lukas
️ Episode 175: Predictive Prioritization of Pancreatic Enhancers Linked to Disease Risk In this episode of PaperCast Base by Base, we explore how en...
174: TMEM217–SLC9C1: Wiring the cAMP Switch for Sperm Motility and Male Fertility
21 Oct 2025
Contributed by Lukas
️ Episode 174: TMEM217–SLC9C1: Wiring the cAMP Switch for Sperm Motility and Male Fertility In this episode of PaperCast Base by Base, we explore...
173: Bottlebrush Block Copolymer Shields Muscles and Prevents DMD Onset
20 Oct 2025
Contributed by Lukas
️ Episode 173: Bottlebrush Block Copolymer Shields Muscles and Prevents DMD Onset In this episode of PaperCast Base by Base, we explore a PNAS stud...
172: When Random DNA Fights Back: De Novo Gene Birth as Antiphage Defense
19 Oct 2025
Contributed by Lukas
️ Episode 172: When Random DNA Fights Back: De Novo Gene Birth as Antiphage Defense In this episode of PaperCast Base by Base, we explore a PNAS st...
171: Virulence Hierarchies in the Tuberculosis Complex—What Makes Some Lineages Deadlier?
18 Oct 2025
Contributed by Lukas
️ Episode 171: Virulence Hierarchies in the Tuberculosis Complex—What Makes Some Lineages Deadlier? In this episode of PaperCast Base by Base, we...
170: Maternal Age, Meiotic Recombination Failure, and Triploidy in Humans
17 Oct 2025
Contributed by Lukas
️ Episode 170: Maternal Age, Meiotic Recombination Failure, and Triploidy in Humans In this episode of PaperCast Base by Base, we explore how mater...
169: Deep mutational scanning of the insulin receptor guides precision therapy for insulin resistance
16 Oct 2025
Contributed by Lukas
️ Episode 169: Deep mutational scanning of the insulin receptor guides precision therapy for insulin resistance In this episode of PaperCast Base b...
168: Low circulating miR-190a-5p predicts progression of chronic kidney disease
15 Oct 2025
Contributed by Lukas
️ Episode 168: Low circulating miR-190a-5p predicts progression of chronic kidney disease In this episode of PaperCast Base by Base, we explore how...
167: DeepScence: Detecting Senescent Cells at Single-Cell and Spatial Resolution
14 Oct 2025
Contributed by Lukas
️ Episode 167: DeepScence: Detecting Senescent Cells at Single-Cell and Spatial Resolution In this episode of PaperCast Base by Base, we explore a ...
166: Molecular Squeezing: How Coronin, Cofilin, and AIP1 Rapidly Disassemble Actin Filaments
13 Oct 2025
Contributed by Lukas
️ Episode 166: Molecular Squeezing: How Coronin, Cofilin, and AIP1 Rapidly Disassemble Actin Filaments In this episode of PaperCast Base by Base, w...
165: Protist Genomics: Key to Understanding Eukaryotic Evolution
12 Oct 2025
Contributed by Lukas
️ Episode 165: Protist Genomics: Key to Understanding Eukaryotic Evolution In this episode of PaperCast Base by Base, we explore how accelerating p...
164: m6A in the coding sequence: linking deposition, translation, and decay
11 Oct 2025
Contributed by Lukas
️ Episode 164: m6A in the coding sequence: linking deposition, translation, and decay In this episode of PaperCast Base by Base, we explore how N6-...
163: Animal origins: looping back in time
10 Oct 2025
Contributed by Lukas
️ Episode 163: Animal origins: looping back in time In this episode of PaperCast Base by Base, we explore how chromatin folding mechanisms emerged ...
162: Spatially Resolved microRNA Expression in Tissues: Technologies, Challenges, and Opportunities
09 Oct 2025
Contributed by Lukas
️ Episode 162: Spatially Resolved microRNA Expression in Tissues: Technologies, Challenges, and Opportunities In this episode of PaperCast Base by ...
161: Decoding Genomic Landscapes of Introgression
08 Oct 2025
Contributed by Lukas
️ Episode 161: Decoding Genomic Landscapes of Introgression In this episode of PaperCast Base by Base, we explore how modern population genetics di...
160: The Long‑Read Leap in Single‑Cell Omics
07 Oct 2025
Contributed by Lukas
️ Episode 160: The Long‑Read Leap in Single‑Cell Omics In this episode of PaperCast Base by Base, we explore how long‑read, single‑molecule...
159: The Untapped Potential of Short‑Read Sequencing in Biodiversity Research
06 Oct 2025
Contributed by Lukas
️ Episode 159: The Untapped Potential of Short‑Read Sequencing in Biodiversity Research In this episode of PaperCast Base by Base, we explore how...
158: Interruptions in Repeat Expansion Diseases: How Are They Gained and Lost?
05 Oct 2025
Contributed by Lukas
️ Episode 158: Interruptions in Repeat Expansion Diseases: How Are They Gained and Lost? In this episode of PaperCast Base by Base, we explore how s...
157: Synthetic gametes and the non-identity problem: the babies of tomorrow
04 Oct 2025
Contributed by Lukas
️ Episode 157: Synthetic gametes and the non-identity problem: the babies of tomorrow In this episode of PaperCast Base by Base, we explore how syn...
156: RAEFISH: Sequencing-free whole-genome spatial transcriptomics at single-molecule resolution
03 Oct 2025
Contributed by Lukas
️ Episode 156: RAEFISH: Sequencing-free whole-genome spatial transcriptomics at single-molecule resolution In this episode of PaperCast Base by Base...
155: EIF3A/EIF3B Loss-of-Function: A Cardiocraniofacial Neurodevelopmental Syndrome
02 Oct 2025
Contributed by Lukas
️ Episode 155: EIF3A/EIF3B Loss-of-Function: A Cardiocraniofacial Neurodevelopmental Syndrome In this episode of PaperCast Base by Base, we explore...
154: Multiple-testing corrections in selection scans using identity-by-descent segments
01 Oct 2025
Contributed by Lukas
️ Episode 154: Multiple-testing corrections in selection scans using identity-by-descent segments In this episode of PaperCast Base by Base, we exp...
153: Skeletal muscle eQTL meta-analysis implicates genes in the genetic architecture of muscular and cardiometabolic traits
30 Sep 2025
Contributed by Lukas
️ Episode 153: Skeletal muscle eQTL meta-analysis implicates genes in the genetic architecture of muscular and cardiometabolic traits In this episo...
152: One-Well Multiplex ddPCR for Hereditary Alpha Tryptasemia
29 Sep 2025
Contributed by Lukas
️ Episode 152: One-Well Multiplex ddPCR for Hereditary Alpha Tryptasemia In this episode of PaperCast Base by Base, we explore a validated single‑...
151: EQA of ctDNA Mutation Testing Across the COIN Consortium
28 Sep 2025
Contributed by Lukas
️ Episode 151: EQA of ctDNA Mutation Testing Across the COIN Consortium In this episode of PaperCast Base by Base, we explore how 16 Dutch laborato...
150: Patrilineal segmentary systems and the post‑Neolithic Y‑chromosome bottleneck
27 Sep 2025
Contributed by Lukas
️ Episode 150: Patrilineal segmentary systems and the post‑Neolithic Y‑chromosome bottleneck In this episode of PaperCast Base by Base, we expl...
149: Cultural Hitchhiking and the Post‑Neolithic Y‑Chromosome Bottleneck
26 Sep 2025
Contributed by Lukas
️ Episode 149: Cultural Hitchhiking and the Post‑Neolithic Y‑Chromosome Bottleneck In this episode of PaperCast Base by Base, we explore how pat...
148: Systematic Minigene-Based Splicing Analysis and Tentative Clinical Classification of 52 CHEK2 Splice-Site Variants
25 Sep 2025
Contributed by Lukas
️ Episode 148: Systematic Minigene-Based Splicing Analysis and Tentative Clinical Classification of 52 CHEK2 Splice-Site Variants In this episode o...
147: Comprehensive Annotation of Complete ABO Alleles and Resolution of ABO Variants
24 Sep 2025
Contributed by Lukas
️ Episode 147: Comprehensive Annotation of Complete ABO Alleles and Resolution of ABO Variants In this episode of PaperCast Base by Base, we explor...
146: Automated and Decentralized Genomic Profiling of Plasma Cell-Free DNA in Solid Tumors
23 Sep 2025
Contributed by Lukas
️ Episode 146: Automated and Decentralized Genomic Profiling of Plasma Cell-Free DNA in Solid Tumors In this episode of PaperCast Base by Base, we ...
145: A Validated Highly Sensitive Microsatellite Instability Assay Identifies PMS2 Variants in CMMRD
22 Sep 2025
Contributed by Lukas
️ Episode 145: A Validated Highly Sensitive Microsatellite Instability Assay Identifies PMS2 Variants in CMMRD In this episode of PaperCast Base by...
144: Revised time estimation of the ancestral human chromosome 2 fusion
21 Sep 2025
Contributed by Lukas
️ Episode 144: Revised time estimation of the ancestral human chromosome 2 fusion In this episode of PaperCast Base by Base, we explore a study tha...
143: The genetic history of the Southern Caucasus: 5,000 years of continuity despite high mobility
20 Sep 2025
Contributed by Lukas
️ Episode 143: The genetic history of the Southern Caucasus: 5,000 years of continuity despite high mobility In this episode of PaperCast Base by B...
142: Specifications of the ACMG/AMP Guidelines for PALB2 Variant Interpretation
19 Sep 2025
Contributed by Lukas
️ Episode 142: Specifications of the ACMG/AMP Guidelines for PALB2 Variant Interpretation In this episode of PaperCast Base by Base, we explore how...
141: RetiGene, a comprehensive gene atlas for inherited retinal diseases
18 Sep 2025
Contributed by Lukas
️ Episode 141: RetiGene, a comprehensive gene atlas for inherited retinal diseases In this episode of PaperCast Base by Base, we explore RetiGene, ...
140: Landscapes of missense variant impact for human superoxide dismutase 1
17 Sep 2025
Contributed by Lukas
️ Episode 140: Landscapes of missense variant impact for human superoxide dismutase 1 In this episode of PaperCast Base by Base, we explore a large...
139: MosCoverY: A new method to estimate mosaic loss of Y chromosome from sequencing coverage data
16 Sep 2025
Contributed by Lukas
️ Episode 139: MosCoverY: A new method to estimate mosaic loss of Y chromosome from sequencing coverage data In this episode of PaperCast Base by B...
138: Social exposome and brain health outcomes of dementia across Latin America
15 Sep 2025
Contributed by Lukas
️ Episode 138: Social exposome and brain health outcomes of dementia across Latin America In this episode of PaperCast Base by Base, we explore how...
137: Rethinking RNA-binding proteins: Riboregulation challenges prevailing views
14 Sep 2025
Contributed by Lukas
️ Episode 137: Rethinking RNA-binding proteins: Riboregulation challenges prevailing views In this episode of PaperCast Base by Base, we explore ho...
136: Gene Context Drift Identifies Drug Targets to Mitigate Cancer Treatment Resistance
13 Sep 2025
Contributed by Lukas
️ Episode 136: Gene Context Drift Identifies Drug Targets to Mitigate Cancer Treatment Resistance In this episode of PaperCast Base by Base, we exp...
135: Global impact of micronutrients in modern human evolution
12 Sep 2025
Contributed by Lukas
️ Episode 135: Global impact of micronutrients in modern human evolution In this episode of PaperCast Base by Base, we explore how dietary micronut...
134: Single-Cell Maps Link Intestinal Metaplasia to Esophageal Adenocarcinoma Risk
11 Sep 2025
Contributed by Lukas
️ Episode 134: Single-Cell Maps Link Intestinal Metaplasia to Esophageal Adenocarcinoma Risk In this episode of PaperCast Base by Base, we explore ...
133: Culture-Independent Meta‑Pangenomics Reveals Gut Genome Links to Child Growth
10 Sep 2025
Contributed by Lukas
️ Episode 133: Culture-Independent Meta‑Pangenomics Reveals Gut Genome Links to Child Growth In this episode of PaperCast Base by Base, we explor...
132: Tumor transcriptome classifiers predict treatment sensitivity in advanced prostate cancer
09 Sep 2025
Contributed by Lukas
️ Episode 132: Tumor transcriptome classifiers predict treatment sensitivity in advanced prostate cancer In this episode of PaperCast Base by Base,...
131: pBI143: The Human Gut’s Hidden Heavyweight
08 Sep 2025
Contributed by Lukas
️ Episode 131: pBI143: The Human Gut’s Hidden Heavyweight In this episode of PaperCast Base by Base, we explore how a tiny 2.7 kb cryptic plasmid...
130: Combining Evidence from Human Genetic and Functional Screens to Identify Pathways Altering Obesity and Fat Distribution
07 Sep 2025
Contributed by Lukas
️ Episode 130: Combining Evidence from Human Genetic and Functional Screens to Identify Pathways Altering Obesity and Fat Distribution In this epis...
129: Structural variation and diversification of the NPIP gene family from the human pangenome
06 Sep 2025
Contributed by Lukas
️ Episode 129: Structural variation and diversification of the NPIP gene family from the human pangenome In this episode of PaperCast Base by Base,...
128: LINE‑1 Promoters Orchestrate Early Human Brain Development
05 Sep 2025
Contributed by Lukas
️ Episode 128: LINE‑1 Promoters Orchestrate Early Human Brain Development In this episode of PaperCast Base by Base, we explore how evolutionaril...
127: In silico generation of synthetic cancer genomes using generative AI
04 Sep 2025
Contributed by Lukas
️ Episode 127: In silico generation of synthetic cancer genomes using generative AI In this episode of PaperCast Base by Base, we explore OncoGAN, ...
126: Molecular and developmental deficits in Smith-Magenis syndrome human stem cell-derived cortical neural models
03 Sep 2025
Contributed by Lukas
️ Episode 126: Molecular and developmental deficits in Smith-Magenis syndrome human stem cell-derived cortical neural models In this episode of Pap...
125: Tackling a disease on a global scale, the Global Parkinson’s Genetics Program, GP2: A new generation of opportunities
02 Sep 2025
Contributed by Lukas
️ Episode 125: Tackling a disease on a global scale, the Global Parkinson’s Genetics Program, GP2: A new generation of opportunities In this episo...
124: Exploring the Omnigenic Architecture of Selected Complex Traits
01 Sep 2025
Contributed by Lukas
️ Episode 124: Exploring the Omnigenic Architecture of Selected Complex Traits In this episode of PaperCast Base by Base, we explore how researcher...
123: Dominant‑Negative ATP5F1A Variants Uncouple Complex V and Drive Neurological Disease
31 Aug 2025
Contributed by Lukas
️ Episode 123: Dominant‑Negative ATP5F1A Variants Uncouple Complex V and Drive Neurological Disease In this episode of PaperCast Base by Base, we...
122: Patient Stratification Reveals the Molecular Basis of Disease Co-Occurrences
30 Aug 2025
Contributed by Lukas
️ Episode 122: Patient Stratification Reveals the Molecular Basis of Disease Co-Occurrences In this episode of PaperCast Base by Base, we explore a...
121: G-quadruplexes as a Source of Vulnerability in BRCA2-deficient Granule Cell Progenitors and Medulloblastoma
29 Aug 2025
Contributed by Lukas
️ Episode 121: G-quadruplexes as a Source of Vulnerability in BRCA2-deficient Granule Cell Progenitors and Medulloblastoma In this episode of Paper...
120: Rare BMAL1 Variants Link the Circadian Clock to Neurodevelopment
28 Aug 2025
Contributed by Lukas
️Episode 120: Rare BMAL1 Variants Link the Circadian Clock to Neurodevelopment In this episode of PaperCast Base by Base, we explore how ultrarare h...
119: G‑Quadruplex Stabilization Triggers Pericentromeric DNA Breaks in B Cells
27 Aug 2025
Contributed by Lukas
️ Episode 119: G‑Quadruplex Stabilization Triggers Pericentromeric DNA Breaks in B Cells In this episode of PaperCast Base by Base, we explore ho...
118: Cancer cells subvert the primate-specific KRAB zinc finger protein ZNF93 to control APOBEC3B
26 Aug 2025
Contributed by Lukas
️ Episode 118: Cancer cells subvert the primate-specific KRAB zinc finger protein ZNF93 to control APOBEC3B In this episode of PaperCast Base by Ba...
117: Pol III–linked polyadenylation fuels SINE RNA accumulation during infection
25 Aug 2025
Contributed by Lukas
️ Episode 117: Pol III–linked polyadenylation fuels SINE RNA accumulation during infection In this episode of PaperCast Base by Base, we explore ...
116: Cell Type–Specific Purifying Selection of Synonymous mtDNA Variation
24 Aug 2025
Contributed by Lukas
️ Episode 116: Cell Type–Specific Purifying Selection of Synonymous mtDNA Variation In this episode of PaperCast Base by Base, we explore how a s...
115: A Transcriptomic, Proteomic, and Functional Genetic Atlas Dissects Neurofibromin Function in the Peripheral Nervous System
24 Aug 2025
Contributed by Lukas
Episode 115: A Transcriptomic, Proteomic, and Functional Genetic Atlas Dissects Neurofibromin Function in the Peripheral Nervous System In this episod...
114: One-hour extraction-free loop-mediated isothermal amplification HPV DNA assay for point-of-care testing in Maputo, Mozambique
22 Aug 2025
Contributed by Lukas
️ Episode 114: One-hour extraction-free loop-mediated isothermal amplification HPV DNA assay for point-of-care testing in Maputo, Mozambique In thi...
113: Joint, Multifaceted Genomic Analysis Enables Diagnosis of Ultra-Rare Monogenic Presentations
21 Aug 2025
Contributed by Lukas
️ Episode 113: Joint, Multifaceted Genomic Analysis Enables Diagnosis of Ultra-Rare Monogenic Presentations In this episode of PaperCast Base by Bas...
112: Local Genetic Sex Differences in Quantitative Traits
20 Aug 2025
Contributed by Lukas
️ Episode 112: Local Genetic Sex Differences in Quantitative Traits In this episode of PaperCast Base by Base, we explore how genetic differences b...
111: A Multimodal Dataset for Precision Oncology in Head and Neck Cancer
19 Aug 2025
Contributed by Lukas
️ Episode 111: A Multimodal Dataset for Precision Oncology in Head and Neck Cancer In this episode of PaperCast Base by Base, we explore the creati...
110: Whole-exome sequencing identifies new schizophrenia risk genes
18 Aug 2025
Contributed by Lukas
️ Episode 110: Whole-exome sequencing identifies new schizophrenia risk genes In this episode of PaperCast Base by Base, we explore a landmark whol...
109: Autocrine Interferon Poisoning: ADAR1–BRCA Synthetic Lethality
17 Aug 2025
Contributed by Lukas
️ Episode 109: Autocrine Interferon Poisoning: ADAR1–BRCA Synthetic Lethality In this episode of PaperCast Base by Base, we explore how loss of t...
108: Epigenome Editing Reverses HBG Silencing
16 Aug 2025
Contributed by Lukas
️ Episode 108: Epigenome Editing Reverses HBG Silencing In this episode of PaperCast Base by Base, we explore how targeted removal of CpG methylati...
107: Genome-wide Association Study Reveals Genetic Links to Pulpal and Apical Diseases
15 Aug 2025
Contributed by Lukas
Episode 107: Genome-wide Association Study Reveals Genetic Links to Pulpal and Apical Diseases In this episode of PaperCast Base by Base, we explore a...
106: Decoding Brain Maps for Pharmacotranscriptomics
14 Aug 2025
Contributed by Lukas
️ Episode 106: Decoding Brain Maps for Pharmacotranscriptomics In this episode of PaperCast Base by Base, we explore a Nature Communications study,...
105: Genome-level Selection as a Universal Marker of Cancer Therapy Resistance
13 Aug 2025
Contributed by Lukas
️ Episode 105: Genome-level Selection as a Universal Marker of Cancer Therapy Resistance In this episode of PaperCast Base by Base, we explore grou...
104: Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation
12 Aug 2025
Contributed by Lukas
Episode 104: Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation In this episode of PaperCast B...
103: Genome Sequencing Forecasts Outcomes After Congenital Cardiac Surgery
11 Aug 2025
Contributed by Lukas
️ Episode 103: Genome Sequencing Forecasts Outcomes After Congenital Cardiac Surgery In this episode of PaperCast Base by Base, we explore how larg...
102: Clinical Impact of Pharmacogenetic Risk Variants in a Large Chinese Cohort
10 Aug 2025
Contributed by Lukas
Episode 102: Clinical Impact of Pharmacogenetic Risk Variants in a Large Chinese Cohort In this episode of PaperCast Base by Base, we explore how larg...
101: JAK2 Inhibition Selects RAS-Mutant Clones in Myelofibrosis
09 Aug 2025
Contributed by Lukas
️Episode 101: JAK2 Inhibition Selects RAS-Mutant Clones in Myelofibrosis In this episode of PaperCast Base by Base, we explore how JAK2 inhibition w...
️ 100: Epigenomic Diagnosis and Prognosis of Acute Myeloid Leukemia
08 Aug 2025
Contributed by Lukas
️ Episode 100: Epigenomic Diagnosis and Prognosis of Acute Myeloid Leukemia In this episode of PaperCast Base by Base, we explore a groundbreaking s...
️ 99: NXT2: A Testis-Specific RNA Export Factor Essential for Spermatogenesis
07 Aug 2025
Contributed by Lukas
️ Episode 99: NXT2: A Testis-Specific RNA Export Factor Essential for Spermatogenesis In this episode of PaperCast Base by Base, we explore how the ...
️ 98: Cell Marker Accordion: Interpretable Single-Cell and Spatial Omics Annotation in Health and Disease
06 Aug 2025
Contributed by Lukas
️ Episode 98: Cell Marker Accordion: Interpretable Single-Cell and Spatial Omics Annotation in Health and Disease In this episode of PaperCast Base ...
️ 97: Pancreatic Cancer Genomics: Insights from the COMPASS Trial
05 Aug 2025
Contributed by Lukas
️ Episode 97: Pancreatic Cancer Genomics: Insights from the COMPASS Trial In this episode of PaperCast Base by Base, we explore how integrated whole...
️ 96: Early Cerebrospinal Fluid Proteomic Changes in Down Syndrome and Alzheimer’s Disease
04 Aug 2025
Contributed by Lukas
️ Episode 96: Early Cerebrospinal Fluid Proteomic Changes in Down Syndrome and Alzheimer’s Disease In this episode of PaperCast Base by Base, we e...
️ 95: Mitochondria on the Move: Biotechnological Strategies for Transfer and Transplantation
03 Aug 2025
Contributed by Lukas
️ Episode 95: Mitochondria on the Move: Biotechnological Strategies for Transfer and Transplantation In this episode of PaperCast Base by Base, we e...
️ 94: Intraindividual Epigenetic Heterogeneity in Advanced Prostate Cancer
02 Aug 2025
Contributed by Lukas
️ Episode 94: Intraindividual Epigenetic Heterogeneity in Advanced Prostate Cancer In this episode of PaperCast Base by Base, we explore how integra...
️ 93: Neuroinvasive and Pulmonary Virulence of H5N1 Clade 2.3.4.4b Genotype B3.13
01 Aug 2025
Contributed by Lukas
️ Episode 93: Neuroinvasive and Pulmonary Virulence of H5N1 Clade 2.3.4.4b Genotype B3.13 In this episode of PaperCast Base by Base, we explore how ...
️ 92: Genetic Loss of CFHR5 Function Protects Against Age-Related Macular Degeneration
31 Jul 2025
Contributed by Lukas
️ Episode 92: Genetic Loss of CFHR5 Function Protects Against Age-Related Macular Degeneration In this episode of PaperCast Base by Base, we explore...
️ 91: Genome-wide Association of Plasma N-Glycome Reveals Links to Liver Disease and Anti-Inflammatory Proteins
30 Jul 2025
Contributed by Lukas
️ Episode 91: Genome-wide Association of Plasma N-Glycome Reveals Links to Liver Disease and Anti-Inflammatory Proteins In this episode of PaperCast...
️ 90: Variable and Interactive Effects of Sex, APOE ε4 and TREM2 on Tau Deposition
29 Jul 2025
Contributed by Lukas
️ Episode 90: Variable and Interactive Effects of Sex, APOE ε4 and TREM2 on Tau Deposition In this episode of PaperCast Base by Base, we explore ho...
️ 89: Decoding the Genetics of Smell: Sex-Specific Variants in Olfactory Identification
28 Jul 2025
Contributed by Lukas
️ Episode 89: Decoding the Genetics of Smell: Sex-Specific Variants in Olfactory Identification In this episode of PaperCast Base by Base, we explor...
️ 88: Stable Heritability of Type 1 Diabetes Over Three Decades in Sweden
27 Jul 2025
Contributed by Lukas
️ Episode 88: Stable Heritability of Type 1 Diabetes Over Three Decades in Sweden In this episode of PaperCast Base by Base, we explore a Swedish na...
️ 87: Circulating cfDNA Methylation Reveals Allograft Injury Sources after Liver Transplant
26 Jul 2025
Contributed by Lukas
️ Episode 87: Circulating cfDNA Methylation Reveals Allograft Injury Sources after Liver Transplant In this episode of PaperCast Base by Base, we ex...
️ 86: Variable Penetrance in Monogenic Traits — How Genetic Background Modulates Disease Severity
25 Jul 2025
Contributed by Lukas
️ Episode 86: Variable Penetrance in Monogenic Traits — How Genetic Background Modulates Disease Severity In this episode of PaperCast Base by Bas...
️ 85: Genomic landscape of virus-associated cancers
24 Jul 2025
Contributed by Lukas
️ Episode 85: Genomic landscape of virus-associated cancers In this episode of PaperCast Base by Base, we explore the comparative genomic analysis o...
️ 84: Variants in NR6A1 cause a novel oculo-vertebral-renal syndrome
23 Jul 2025
Contributed by Lukas
️ Episode 84: Variants in NR6A1 cause a novel oculo-vertebral-renal syndrome In this episode of PaperCast Base by Base, we explore the discovery of ...
️ 83: Single-cell Analysis of dup15q Syndrome Illuminates Autism Mechanisms
22 Jul 2025
Contributed by Lukas
️ Episode 83: Single-cell Analysis of dup15q Syndrome Illuminates Autism Mechanisms In this episode of PaperCast Base by Base, we explore how single...
️ 82: JAK2 Inhibition Drives RAS Pathway Mutant Clonal Selection in Myeloproliferative Neoplasms
21 Jul 2025
Contributed by Lukas
️ Episode 82: JAK2 Inhibition Drives RAS Pathway Mutant Clonal Selection in Myeloproliferative Neoplasms In this episode of PaperCast Base by Base, ...
️ 81: Clinical Impact of Pharmacogenetic Risk Variants in a Large Chinese Cohort
20 Jul 2025
Contributed by Lukas
️ Episode 81: Clinical Impact of Pharmacogenetic Risk Variants in a Large Chinese Cohort In this episode of PaperCast Base by Base, we explore a ret...