Sabemos que a vida, depois de surgir, foi capaz de proliferar e diversificar até que preenchesse todos os nichos do planeta. Mas, uma questão permanece - como a vida surgiu da matéria inorgânica. Separe meia horinha do seu dia e descubra com a Dra. Mila Massuda (@milamassuda) do BlaBlaLogia (@blablalogia) o que a ciência sabe, até o momento, sobre o surgimento da vida na Terra. Apresentação: Mila Massuda (@milamassuda) Roteiro: Mila Massuda (@milamassuda) e Emilio Garcia (@emilioblablalogia) Edição: @Matheus_Heredia (@mewmediaLAB) Produção Prof. Vítor Soares (@profvitorsoares) e BláBláLogia (@blablalogia) REFERÊNCIAS: GOMES, Edward; SHORTER, James. The molecular language of membraneless organelles. Journal of Biological Chemistry, v. 294, n. 18, p. 7115-7127, 2019. https://doi.org/10.1074/jbc.TM118.001192 GÖZEN, Irep et al. Protocells: Milestones and recent advances. Small, v. 18, n. 18, p. 2106624, 2022. https://doi.org/10.1002/smll.202106624 JORDAN, Sean F. et al. Spontaneous assembly of redox-active iron-sulfur clusters at low concentrations of cysteine. Nature communications, v. 12, n. 1, p. 5925, 2021. https://doi.org/10.1038/s41467-021-26158-2 KITADAI, Norio; MARUYAMA, Shigenori. Origins of building blocks of life: A review. Geoscience Frontiers, v. 9, n. 4, p. 1117-1153, 2018. https://doi.org/10.1016/j.gsf.2017.07.007 MENOR SALVÁN, Cesar et al. Prebiotic Origin of Pre‐RNA Building Blocks in a Urea “Warm Little Pond” Scenario. ChemBioChem, v. 21, n. 24, p. 3504-3510, 2020. https://doi.org/10.1002/cbic.202000510 MUCHOWSKA, Kamila B.; MORAN, Joseph. Peptide synthesis at the origin of life. Science, v. 370, n. 6518, p. 767-768, 2020. https://www.science.org/doi/10.1126/science.abf1698 OBA, Yasuhiro et al. Identifying the wide diversity of extraterrestrial purine and pyrimidine nucleobases in carbonaceous meteorites. Nature communications, v. 13, n. 1, p. 2008, 2022. https://doi.org/10.1038/s41467-022-29612-x PAPINEAU, Dominic et al. Metabolically diverse primordial microbial communities in Earth’s oldest seafloor-hydrothermal jasper. Science Advances, v. 8, n. 15, p. eabm2296, 2022. https://www.science.org/doi/full/10.1126/sciadv.abm2296 PODOLSKY, Kira A.; DEVARAJ, Neal K. Synthesis of lipid membranes for artificial cells. Nature Reviews Chemistry, v. 5, n. 10, p. 676-694, 2021. https://doi.org/10.1038/s41570-021-00303-3 SASSELOV, Dimitar D.; GROTZINGER, John P.; SUTHERLAND, John D. The origin of life as a planetary phenomenon. Science Advances, v. 6, n. 6, p. eaax3419, 2020. https://www.science.org/doi/10.1126/sciadv.aax3419 STOLAR, Tomislav et al. Mechanochemical prebiotic peptide bond formation. Angewandte Chemie International Edition, v. 60, n. 23, p. 12727-12731, 2021. doi: 10.26434/chemrxiv.13187852.v SZOSTAK, Jack W. The narrow road to the deep past: in search of the chemistry of the origin of life. Angewandte Chemie International Edition, v. 56, n. 37, p. 11037-11043, 2017. https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201704048 ZHU, Ting F.; SZOSTAK, Jack W. Coupled growth and division of model protocell membranes. Journal of the American Chemical Society, v. 131, n. 15, p. 5705-5713, 2009. https://doi.org/10.1021/ja900919c

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