Blood Podcast
Episodes
Transplant outcomes in adults with immunodeficiencies and erythroblastic islands as niches for terminal erythropoiesis and granulopoiesis
07 Oct 2022
Contributed by Lukas
In this week’s episode we'll review results of the largest retrospective study to date of allogeneic transplantation in adult patients with inborn e...
Ticagrelor in pediatric sickle cell disease, UBA1 translation impacts severity of VEXAS syndrome, and T-cell immunity and chemotherapy response in ALL
29 Sep 2022
Contributed by Lukas
In this week’s episode we’ll learn more about the negative findings from the phase three trial of ticagrelor for preventing vaso-occlusive crises ...
Race affects treatment outcomes in iTTP, 2022 ELN AML recommendations, and a comprehensive MRD assessment in MCL
22 Sep 2022
Contributed by Lukas
In this week’s episode we’ll take a quick look at the latest European Leukemia Net recommendations for the diagnosis and management of acute myelo...
The International Consensus Classification: An interview with Drs. Daniel Arber and Elias Campo
15 Sep 2022
Contributed by Lukas
In this bonus episode, we’re delighted to have Dr. Dan Arber from the University of Chicago and Dr. Elias Campo from the University of Barcelona. Wi...
Tranexamic acid prophylaxis in heme malignancies, N-glycosylation as a therapeutic vulnerability in CALR-mutant MPN, and myocardial fibrosis in sickle cell anemia
15 Sep 2022
Contributed by Lukas
In this week’s episode we’ll discuss the efficacy of tranexamic acid prophylaxis in patients with hematological malignancies, learn more about N-g...
Rest alleviates T-cell exhaustion by bispecific antibodies, exercise vs desmopressin in mild hemophilia A, and targeting MDM2 to enhance antileukemia immunity after transplant
08 Sep 2022
Contributed by Lukas
Sutimlimab vs placebo in cold agglutinin disease, the impact of etoposide versus auto-transplant in PTCL, and the role of pulmonary NETs in sickle cell disease
01 Sep 2022
Contributed by Lukas
In this week’s episode, we review results of a randomized, placebo-controlled phase 3 trial demonstrating that targeted inhibition of C1s with the m...
Rivaroxaban after cancer surgery, genetics and survival in severe aplastic anemia, and a 5-year follow up of rituximab-venetoclax in relapsed/refractory CLL
25 Aug 2022
Contributed by Lukas
In this week’s episode discuss the efficacy of rivaroxaban as antithrombotic prophylaxis after laparoscopic surgery for colorectal cancer, learn mor...
Stroke in hereditary TTP, and germline DDX41 variants as risk factors and prognostic markers in myeloid neoplasms
18 Aug 2022
Contributed by Lukas
In this week’s episode, we’ll learn more about neuropsychiatric manifestations and stroke risk in hereditary TTP, discuss germline DDX41 variants ...
Cost effectiveness of first-line daratumumab in MM, base-edited CAR T cells for T-ALL, and the role of SETBP1 mutations in chronic neutrophilic leukemia
11 Aug 2022
Contributed by Lukas
In this week’s episode new research suggesting that, in patients with transplant-eligible multiple myeloma, adding daratumumab to first-line combina...
Immune thrombocytopenia and adenoviral SARS-COV2 vaccines, genomics, and a risk assessment model of anti-CD19 CAR T-cell treatment outcomes in lymphoma
04 Aug 2022
Contributed by Lukas
In this week’s episode we’ll discuss the factors influencing the development of immune thrombocytopenia after administration of the ChAdOx1 nCov-1...
Naturally selected CD7 CAR T cell therapy for T-lineage malignancies, CD4+ T cell exhaustion and PD-L1 inhibition in B-ALL, and tPA-induced phosphorylation of occludin in stroke
28 Jul 2022
Contributed by Lukas
In this week’s episode we review a novel approach to generating autologous CD7-specific CAR T therapy for patients with T-cell malignancies that ove...
Role of PIEZO1 in leukocyte extravasation, CD8+ T-cell activation in macrophage activation syndrome, and ABO O blood group as a novel risk factor for HIT
21 Jul 2022
Contributed by Lukas
In this week’s episode we first review new work revealing the critical role of the tension-sensitive cation channel PIEZO1 in the transendothelial m...
Long-term ibrutinib-rituximab vs FCR in CLL, procoagulant platelet sentinels in prevention of inflammatory bleeding, and new SERPINC1 variants in thrombophilia
14 Jul 2022
Contributed by Lukas
In this week’s episode we’ll compare the long-term outcomes of ibrutinib-rituximab combination therapy versus FCR chemoimmunotherapy in chronic ly...
Malignancy risk from genetically modified immune effector cells, p53 immunohistochemistry as a new tool in AML, and phenotypic escape from CD19-directed immunotherapies.
07 Jul 2022
Contributed by Lukas
Today we’ll learn more about the risk of subsequent malignancies in patients treated with genetically modified immune effector cells, discuss how p5...
Overcoming CAR T cell resistance in myeloma, why anti-CCR4 antibody therapy in CTCL sometimes fails, and corticosteroids increase risk of VOE in sickle disease
30 Jun 2022
Contributed by Lukas
In this week’s episode we review a novel strategy for overcoming resistance to CAR T cell therapy that involves the dual targeting of myeloma cells ...
Salvage therapy with NICE for Hodgkin lymphoma, BMP2/SMAD pathway activation in leukemic transformation, and the role of zinc in T-cell reconstitution after HSCT
23 Jun 2022
Contributed by Lukas
In this week’s episode we’ll learn more about salvage therapy with nivolumab plus or minus ICE (or NICE) for Hodgkin lymphoma, discuss the role of...
MRD and post-transplant outcomes in older AML patients, enhancer hijacking in a novel high-risk B-other ALL subtype, and ruxolitinib in pediatric HLH
16 Jun 2022
Contributed by Lukas
In this week’s episode we will discuss new data demonstrating that, in older patients with AML, post-transplant relapse risk is driven by clinical a...
Anti-PF4 antibodies after Covid vaccination, CAR T-cell therapy for CNS leukemia, and advances in Diamond-Blackfan anemia
09 Jun 2022
Contributed by Lukas
In this week's episode, we’ll learn more about the interaction between anti-PF4 antibodies and anticoagulants in vaccine-induced thrombotic thromboc...
Fixed-duration ibrutinib + venetoclax for CLL, aryl hydrocarbon receptor in idiopathic pneumonia syndrome, and VWF propeptide and multimerization
02 Jun 2022
Contributed by Lukas
In this week's episode, we discuss results from the international phase 2 CAPTIVATE study showing that in patients with treatment-naive CLL, fixed-dos...
HEATR3 variants as a new cause of Diamond-Blackfan anemia, zanubrutinib in mantle cell lymphoma, and HMGB1 inhibits Epo signaling in anemia of inflammation
26 May 2022
Contributed by Lukas
In this week's episode we discuss the role of HEATR3 variants as a new cause of Diamond-Blackfan anemia, learn more about the long-term efficacy and s...
HLA-DQ heterodimers and transplantation, the genomic landscape of LGL leukemia, and an updated classification of hemochromatosis
19 May 2022
Contributed by Lukas
In this week’s episode we’ll feature new research demonstrating that certain HLA-DQ heterodimers can help predict clinical outcome following hemat...
Role of macrophage NOX2 in alveolar homeostasis, hydroxyurea versus peginterferon alfa-2a in high-risk PV and ET, and the emerging PV treatment landscape
12 May 2022
Contributed by Lukas
In this week’s episode we’ll discuss an undescribed role for NOX2 in maintaining lung homeostasis through suppression of alveolar macrophage activ...
Microbiome and CD4 T-cell recovery after allogeneic HCT, and a paradigm shift to CAR T-cells in the second line for large B-cell lymphoma?
05 May 2022
Contributed by Lukas
In this week’s episode we’ll discuss the effects of intestinal microbial diversity on patient outcomes following allogeneic hematopoietic cell tra...
Canakinumab in SCA, antigen-specific donor T-cells to prevent post-transplant relapse in ALL, and nasopharyngeal mucosal immunity defects in transplanted SCID patients
28 Apr 2022
Contributed by Lukas
In this week’s episode, we’ll discuss the efficacy of canakinumab in children and young adults with sickle cell anemia, learn more about the use o...
Timing (and utility) of CNS prophylaxis in DLBCL, Apollo deficiency in a bone marrow failure syndrome, and GATA1 mutants in congenital anemia
21 Apr 2022
Contributed by Lukas
In this week’s episode we’ll cover a retrospective study on the timing of high-dose methotrexate CNS prophylaxis in diffuse large B-cell lymphoma,...
Obinutuzumab plus lenalidomide in advanced follicular lymphoma, mechanisms of anemia in children with malaria, and granulocyte microvesicles for septic shock
14 Apr 2022
Contributed by Lukas
In this week’s episode we’ll discuss the efficacy of the obinutuzumab-lenalinomide combination in advanced follicular lymphoma, learn more about t...
Structural racism and AML survival, promoter competition and hemoglobin switching, and CAR T-cell therapy and high-risk cytogenetics in ALL
07 Apr 2022
Contributed by Lukas
In this week’s episode we’ll first cover a research article demonstrating the striking contribution of neighborhood disadvantage to racial and eth...
Targeting the PBX1-FOXM1 axis in myeloma, SF3B1 mutations in MDS, and pulmonary artery hypertension-associated mortality in β-thalassemia patients
31 Mar 2022
Contributed by Lukas
In this week's podcast, we’ll discuss the role of the PBX1-FOXM1 axis in multiple myeloma, learn more about the pathobiology of SF3B1 splicing facto...
Novel high-risk subtypes in adult B-ALL, Liso-cel CAR-T therapy in CLL, and liquid biopsies in large B-cell lymphomas
24 Mar 2022
Contributed by Lukas
In this week's podcast, we’ll cover a research article that describes two novel subgroups of adult B-cell ALL with high expression of CDX2 and IDH m...
Effective treatments for kaposiform hemangioendothelioma, causes of vascular dysfunction in sickle cell patients, and better strategies to select therapy in older adults with AML
17 Mar 2022
Contributed by Lukas
In this week's podcast, discuss the efficacy of siroliumus plus prednisolone in kaposiform hemangioendothelioma with the Kasabach-Merritt phenomenon, ...
COVID-19 vaccination in patients with blood cancers and recalibrating the HLA barrier in haploidentical stem cell transplantation
10 Mar 2022
Contributed by Lukas
In this week's podcast, we’ll focus on 2 reports on clinical outcomes following COVID-19 vaccination in patients with hematologic malignancies. Desp...
Cell therapy options for chemo-sensitive DLBCL, PIGA mutations in a novel subtype of hemochromatosis, and triplet combination therapy in high-risk CLL
03 Mar 2022
Contributed by Lukas
In this week's podcast, we’ll compare the efficacy of autologous stem cell transplant to CAR T-cell therapy for relapsed diffuse large B-cell lympho...
Germline predisposition mutations in AML, a new way to resolve NETs, and venetoclax and BAX mutations in normal myeloid cells of CLL patients
24 Feb 2022
Contributed by Lukas
In this week's podcast, we’ll look at work from researchers who found pathogenic or likely pathogenic variants of cancer predisposition genes in nea...
Ovarian reserve in sickle cell anemia, genomic landscape of adult T-cell leukemia/lymphoma, and a new prognostic index for HLH-associated heme malignancies
17 Feb 2022
Contributed by Lukas
In this week’s podcast, we’ll discuss diminished ovarian reserve in young women with sickle cell anemia, learn more about genomic alterations in a...
Role of HBO1 in HSC function, robust MRD analysis in multiple myeloma, and cardiac ferroptosis in sickle cell disease
10 Feb 2022
Contributed by Lukas
In this week’s podcast, we’ll look at research demonstrating that the histone acetyltransferase HBO1 is an essential regulator of hematopoietic st...
The ARID3A transcription factor suppresses leukemia, a COVID-19 booster shot benefits CLL patients, and advances in the genetics of congenital neutropenia
03 Feb 2022
Contributed by Lukas
In this week’s podcast, we’ll discuss the role of megakaryocytic transcription factor ARID3A in leukemia suppression, learn more about the efficac...
Sustained MRD negativity & outcomes in myeloma, therapeutic targeting of VWF in TTP, and improving CAR T-cells in CLL with PI3 kinase inhibition
28 Jan 2022
Contributed by Lukas
On this week’s podcast, we’ll review a recent analysis of phase 3 daratumumab studies looking at the prognostic impact of sustained minimal residu...
Does route of CNS prophylaxis for DLBCL matter?, the connection between CHIP and COPD, and ATRA plus low-dose rituximab in ITP
20 Jan 2022
Contributed by Lukas
In this week’s podcast, we’ll discuss real-world outcomes comparing route of CNS prophylaxis for aggressive non-Hodgkin lymphomas, learn more abou...
A spectrum of ALK-positive histiocytosis, and metabolites as biomarkers for GvHD diagnosis and risk assignment
13 Jan 2022
Contributed by Lukas
On today’s podcast, we’ll explore the largest case series to date describing ALK-positive histiocytosis. The authors provide new insights on the d...
Long-term outcomes in severe aplastic anemia, cytoprotective effects of factor VIIa, and the role of IL-1 in hematopoietic stem cell ageing
06 Jan 2022
Contributed by Lukas
In this week’s podcast, we’ll talk about the long-term outcomes in patients with severe aplastic anemia treated with immunosuppression and eltromb...
CRISPR cure for XMEN disease?, JAK inhibition in T-cell lymphomas, and intracranial hemorrhage in hemophilia
30 Dec 2021
Contributed by Lukas
In this week’s episode, we’ll review a research article that provides the first description of a targeted gene insertion approach to correct the g...
Antigen presentation by platelet extracellular vesicles, fibril-reactive monoclonal antibody therapy for AL amyloidosis, and targeting gasdermin D in sepsis
23 Dec 2021
Contributed by Lukas
In this week’s episode, we’ll review a research article demonstrating that some platelet-derived extracellular vesicles harbor proteasomes that ca...
Mesenchymal stromal cells in SCD, CAR T-cell-mediated hematotoxicity in B-cell lymphoma, and dual cytokine blockade in GVHD
16 Dec 2021
Contributed by Lukas
In this week’s episode, we’ll talk about the functional properties of mesenchymal stromal cells in sickle cell disease, learn more about CAR T-cel...
PROTACs for JAKs in CRLF2-rearranged ALL, risk stratification in Down syndrome-associated leukemia, and how losing sialic acid activates immune cells in ITP
09 Dec 2021
Contributed by Lukas
In this week’s episode, we’ll learn about a new approach for targeting Janus kinases in CRLF2-rearranged ALL, discuss risk stratification for myel...
Belumosudil for chronic GVHD, mechanistic insights into VITT, and factors driving molecular response in IFNα-treated MPNs
02 Dec 2021
Contributed by Lukas
First on today’s podcast, we’ll review results of a randomized phase 2 study demonstrating that inhibition of ROCK2 with belumosudil is well toler...
Post-vaccination COVID-19 in patients with hematologic malignancies
01 Dec 2021
Contributed by Lukas
All four studies included in this podcast present preliminary data with modest numbers of patients, and therefore, the findings should be interpreted ...
Asciminib versus bosutinib in CML; dopamine signaling and hematopoietic stem cells; complement factor C5 and VTE risk
25 Nov 2021
Contributed by Lukas
In this week’s episode, we’ll learn more about the efficacy of asciminib in patients with chronic myeloid leukemia who are resistant or intolerant...
Danicopan add-on therapy in PNH, neural networks to identify bone marrow cells, and RNA editome and hematopoiesis
18 Nov 2021
Contributed by Lukas
In this week’s episode, we’ll review results of a phase 2 study showing the beneficial effects of a first-in-class factor D inhibitor as add-on th...
Machine learning in classification of AML, aging bone marrow in leukemia, and treating bleeding disorders of unknown cause
11 Nov 2021
Contributed by Lukas
In this week’s episode, we’ll learn more about the application of machine learning in molecular subclassification and prognostication of acute mye...
Anti-CD36-antibody therapy of neonatal alloimmune thrombocytopenia, costs of hemophilia B gene therapy, and insights into erythroid maturation
04 Nov 2021
Contributed by Lukas
In this week’s episode, we’ll review a research article showing beneficial effects of prenatal immunotherapy in a mouse model of anti-CD36-mediate...
Genetic risks for CMV after BMT, multiplex gene editing to reactivate HbF, and rewiring plasma cells in light chain amyloidosis and myeloma
28 Oct 2021
Contributed by Lukas
In this week’s episode, we’ll discuss an analysis of genetic risks for CMV infection after an allogeneic hematopoietic stem cell transplant, learn...
Omidubicel vs standard umbilical cord blood transplant, CAR T-cell associated lymphomas, and CD63 and ferritin export
21 Oct 2021
Contributed by Lukas
In this week’s episode, we’ll review results of a phase 3 randomized study demonstrating shorter time to neutrophil and platelet recovery with an ...
Iron homeostasis and anemia of inflammation in TB, and long-term outcomes of gene therapy in adenosine deaminase-deficient SCID patients
14 Oct 2021
Contributed by Lukas
In this week’s episode, we will review a study that prospectively followed tuberculosis patients after treatment initiation to evaluate iron handlin...
Immune megakaryocytes, PD1 deletions in CTCL, and COVID-19 vaccine and VITT
07 Oct 2021
Contributed by Lukas
In this week’s episode, we’ll review a study providing new insights on megakaryocyte diversity and function, including a unique subpopulation that...
Inhibition of P-selectin as an anticoagulant, prognostic implications of CEBPA mutations in AML, and treating sickle cell disease with voxelitor
30 Sep 2021
Contributed by Lukas
In this week’s episode, we’ll review a study that demonstrates the efficacy of a synthetic inhibitor termed P-G6 that blocks P-selectin signaling ...
Caution on JAK inhibitors in HLH, CD44 loss sensitizes AML to venetoclax, and new insights on cell cycle control in Richter transformation
23 Sep 2021
Contributed by Lukas
In this week’s episode, we review results of preclinical investigations that sound a note of caution regarding the potential use of JAK inhibitors a...
Improved risk assessment in adult BCR-ABL1-negative B-ALL, value of clone metrics in clonal cytopenias, a placental protease generates a peptide to inhibit NET formation
16 Sep 2021
Contributed by Lukas
In this week’s episode, we will review an integrated analysis of one of the largest adult BCR-ABL1-negative B-ALL patient cohorts treated in a singl...
Fixed-duration venetoclax in relapsed CLL, differing effects of invariant NK T cells, and under recognition of rare TERT variants in MDS
09 Sep 2021
Contributed by Lukas
In this week’s episode, we’ll review updated results of a phase 1b study that provide strong support for the use of fixed-duration venetoclax in p...
Activated BCL11B in acute leukemias, SARS-CoV-2 antibody responses in lymphoma patients receiving B-cell therapies, and PD-L1 in neutrophil apoptosis and tissue inflammation
02 Sep 2021
Contributed by Lukas
In this week’s episode, we will review a study that shows that BCL11B is an important oncogene in acute leukemias with myeloid and T-lymphoid featur...
IFN-λ therapy for GvHD, mechanism of decitabine in ITP, and TET2 mutations in chronic NK-LGL leukemia
26 Aug 2021
Contributed by Lukas
In this week's episode, we will review a study that proposes IFN-λ therapy as a novel strategy to boost gut protection in GvHD, examine the immunomod...
Review Series on Mechanisms of Hematologic Malignancies
26 Aug 2021
Contributed by Lukas
To reach the goal of curing currently incurable hematologic malignancies, we need to go beyond focusing on single gene mutations and gain deeper under...
Choosing chemotherapy for older patients with AML, the role of the microenvironment in pediatric ALL, and efficacy of thrombopoietin receptor agonists in elderly patients with ITP
19 Aug 2021
Contributed by Lukas
In this week's episode, we will review a report on a clinical prognostic tool that identifies which group of older, fit acute myeloid leukemia patient...
Brentuximab plus nivolumab in refractory/relapsed Hodgkin lymphoma, the signature of aging hematopoietic stem cells, and hepatocyte neogenin in iron homeostasis
12 Aug 2021
Contributed by Lukas
In this week's episode, we’ll discuss the safety and efficacy of brentuximab vedotin in combination with nivolumab in patients with relapsed and ref...
Latest Research on the Intensity of AML Therapy in Older Patients, Platelets and T cell Activity in Sepsis, and Genotyping for CNS Lymphoma
05 Aug 2021
Contributed by Lukas
In this week's episode, we’ll start by reviewing an intriguing study that, while not randomized, calls into question whether less-intensive inductio...
Vaccine-induced Immune Thrombotic Thrombocytopenia
29 Jul 2021
Contributed by Lukas
Today’s episode is a special edition that focuses exclusively on vaccine-induced immune thrombotic thrombocytopenia, or VITT, a rare but potentially...
Latest research in post-transplant cyclophosphamide in matched unrelated versus haploidentical donors, outcomes in patients with AITL, and high molecular weight kininogen in acetaminophen-induced liver injury
22 Jul 2021
Contributed by Lukas
In this week’s episode, we will learn more about the use of high-dose post-transplant cyclophosphamide in matched unrelated donors versus HLA haploi...
Latest research in thrombosis in pediatric COVID-19, prognostic tool for very early stage CLL, and frontline treatment for newly diagnosed myeloma
15 Jul 2021
Contributed by Lukas
In this week's episode, our studies include an analysis of thrombosis in pediatric patients with COVID-19, the predictive value of the CLL-internation...
Latest Research: Immunity to CMV, lymphoma microenvironment, and tPA induced bleeding
08 Jul 2021
Contributed by Lukas
In this week's episode, we will review a study that addresses the issue of reconstitution of immunity to cytomegalovirus in transplant patients receiv...
VEXAS: A Newly Identified Adult-onset Hemato-inflammatory Syndrome
01 Jul 2021
Contributed by Lukas
Today’s podcast is a special edition that focuses exclusively on VEXAS syndrome, a newly identified adult-onset inflammatory syndrome with associate...
Season 2, Episode 25
24 Jun 2021
Contributed by Lukas
In this week’s episode, we will review a study that uses a combination of mouse models to identify IL-19 as a potent cytokine capable of promoting e...
Season 2, Episode 24
17 Jun 2021
Contributed by Lukas
In this week’s episode, we will review the role of the hypoxia pathway in regulating neutrophil migration, explore the relationship between endothel...
Review Series on Platelets and Cancer
10 Jun 2021
Contributed by Lukas
Platelets are critical for hemostasis and thrombosis, but recent research highlights their role in many other processes, including inflammation, wound...
Season 2, Episode 23
10 Jun 2021
Contributed by Lukas
In this week’s episode, we will review a study demonstrating low rates of response to the Pfizer-BioNTech COVID-19 vaccine among patients with chron...
Season 2, Episode 22
03 Jun 2021
Contributed by Lukas
In this week’s episode, we will review a study in sickle cell disease patients reporting abnormal retention of mitochondria in circulating red cells...
Season 2, Episode 21
27 May 2021
Contributed by Lukas
In this week’s episode we will review a phase 1 clinical trial looking at novel fully humanized BCMA-targeting CAR in patients with relapsed or refr...
Season 2, Episode 20
20 May 2021
Contributed by Lukas
In this week’s episode, we will examine the prognostic significance of co-mutations in IDH-mutated AML, explore an alternative method of warfarin mo...
Season 2, Episode 19
13 May 2021
Contributed by Lukas
In this week’s episode, we will review a randomized phase 3 study of patients with high-risk peripheral T-cell lymphoma that compares results from a...
Season 2, Episode 18
06 May 2021
Contributed by Lukas
In this week’s episode, we will review a prospective study suggesting that eculizumab discontinuation based on complement genetics is a reasonable a...
Season 2, Episode 17
29 Apr 2021
Contributed by Lukas
In this week’s episode, we will review a study that focuses on the morphologic alterations of stored red blood cells, learn more about how T-cell ac...
Season 2, Episode 16
22 Apr 2021
Contributed by Lukas
In this week’s episode, we consider the role of MYC and BCL2 copy number variants in double-hit diffuse large B-cell lymphoma, explore megakaryocyte...
Season 2, Episode 15
15 Apr 2021
Contributed by Lukas
In this week’s episode, we will review a manuscript that describes a novel inherited bone marrow failure syndrome associated with defective clearanc...
Season 2, Episode 14
08 Apr 2021
Contributed by Lukas
In this week’s episode, we discuss recent studies providing new insights on the use of minimal residual disease measurements to guide treatment in p...
Season 2, Episode 13
01 Apr 2021
Contributed by Lukas
In this week’s episode, we will learn more about the feasibility of combining IDH inhibitors with intensive chemotherapy in patients with newly diag...
Season 2, Episode 12
25 Mar 2021
Contributed by Lukas
In this week’s episode, we look at the role of a previously unidentified variant of DNA methyltransferase 1 as a determinant of beta-thalessemia phe...
Season 2, Episode 11
18 Mar 2021
Contributed by Lukas
In this week’s episode, will review a study that looks at primary diffuse large B-cell lymphoma of the central nervous system comparing tumor biolog...
Season 2, Bonus: How I Treat Series: Acquired Hemolytic Anemia
15 Mar 2021
Contributed by Lukas
Diagnosis and treatment of acquired hemolytic anemia can be challenging. In this How I Treat series, edited by Mario Cazzola, clinical experts discuss...
Season 2, Episode 10
11 Mar 2021
Contributed by Lukas
In this week’s episode, we will review recent studies providing new insights on frontline use of checkpoint inhibitors in classical Hodgkin lymphoma...
Season 2, Episode 9
04 Mar 2021
Contributed by Lukas
In this week’s episode, we will review a study that provides further evidence of poor prognosis in patients with multiple myeloma who have “double...
Season 2, Episode 8
25 Feb 2021
Contributed by Lukas
In this week’s episode, we will learn more about pre-clinical work that aims to identify optimal immunotargets for treatment of pediatric AML, repor...
Season 2, Episode 7
18 Feb 2021
Contributed by Lukas
In this week’s episode, we will learn about the cost effectiveness of caplacizumab in acquired thrombotic thrombocytopenic purpura, review outcomes ...
Season 2, Episode 6
11 Feb 2021
Contributed by Lukas
In this week’s episode, we will cover recent research that provides new insights into the treatment of relapsed or refractory acute myeloid leukemia...
Season 2, Episode 5
04 Feb 2021
Contributed by Lukas
In this week’s episode, we will review a study that describes the pathogenic relevance of retinoic acid-responsive CD8+ T-cells in gastrointestinal ...
Season 2, Episode 4
28 Jan 2021
Contributed by Lukas
In this week’s episode, we will explore the characteristics of the tumor and immune environment as predictors of response to blinatumomab in B cell ...
Season 2, Episode 3
21 Jan 2021
Contributed by Lukas
In this week’s episode, we will review a study that shows neutrophils are required for optimum recovery from acute lung injury in a murine model, ex...
Season 2, Episode 2
14 Jan 2021
Contributed by Lukas
This week’s episode covers recent research that provides new insights in erythropoiesis, mastocytosis, and chronic active EBV. First, we’ll review...
Season 2, Episode 1
07 Jan 2021
Contributed by Lukas
In this week’s episode, we will review a study that shows that non-invasive imaging of T cell metabolic activity can detect early graft-versus-host ...
Season 1, Episode 52
24 Dec 2020
Contributed by Lukas
In this week’s episode, we will review a study that evaluates the role of pre-transplant leukocyte telomere length on survival outcomes in patients ...
Season 1, Episode 51
17 Dec 2020
Contributed by Lukas
In this week’s episode, we will learn more about T-cells from SARS-CoV-2-infected individuals, review a study that describes the rapid clinical and ...
Season 1, Episode 50
10 Dec 2020
Contributed by Lukas
In this week’s episode, we will review a study describing real-world data where PET scans following chemotherapy for primary mediastinal B-cell lymp...