Blood Podcast
Episodes
Season 1, Episode 49
03 Dec 2020
Contributed by Lukas
In this week’s episode, we will review a study that describes how transfer of whole mitochondria from hematopoietic stem cells to bone marrow mesenc...
Season 1, Episode 48
26 Nov 2020
Contributed by Lukas
In this week’s episode, we will review a study that reveals a previously unknown role for the canonical Wnt signaling pathway in the regulation of g...
Season 1, Episode 47
19 Nov 2020
Contributed by Lukas
In this week’s episode, we will review an proof-of concept study using the bispecific antibody AFM13 in combination with a check-point inhibitor in ...
Season 1, Episode 46
12 Nov 2020
Contributed by Lukas
In this week’s episode, we will review a study on the involvement of lysine-specific, we’ll cover some of the latest findings in COVID-19, multipl...
Season 1, Episode 45
05 Nov 2020
Contributed by Lukas
In this week’s episode, we will review a study on the involvement of lysine-specific demethylase 1A in hematopoietic stem cell expansion, examine th...
Season 1, Episode 44
29 Oct 2020
Contributed by Lukas
In this week’s episode, we will review a study that uncovers a role for CLCX4 in inducing the two hallmark features of primary myelofibrosis, bone m...
Season 1, Episode 43
22 Oct 2020
Contributed by Lukas
In this week’s episode, we will learn more about the immune defects and granule dysfunction in the leukocytes of patients with the rare recessive pl...
Season 1, Episode 42
15 Oct 2020
Contributed by Lukas
In this week’s episode, we will review a study that utilized whole-genome sequencing to define the mutational spectrum and clonal architecture of my...
Season 1, Episode 41
08 Oct 2020
Contributed by Lukas
In this week’s episode, we will learn about two molecular brakes that regulate platelet activation and production, review a study showing that givin...
Review Series on Mechanisms and Clinical Implications of Clonal Hematopoiesis
01 Oct 2020
Contributed by Lukas
In this bonus episode, we welcome Blood Associate Editor, Dr. Margaret Goodell, along with colleagues Dr. Grant Challen and Dr. David Steensma as they...
Season 1, Episode 40
01 Oct 2020
Contributed by Lukas
In this week’s episode, we will learn more about the pre-clinical and clinical development of optimized, bivalent, tandem CD20 and CD19 chimeric ant...
Season 1, Episode 39
24 Sep 2020
Contributed by Lukas
In this week’s episode, we will learn more about the role of hepcidin in fetal iron homeostasis, review a new study with improved outcomes in HLA-an...
Season 1, Episode 38
17 Sep 2020
Contributed by Lukas
In this week’s episode, we will examine the effects of protecting and regenerating Paneth cells and intestinal stem cells in acute-graft-versus-host...
Review Series on Inherited Anemias
10 Sep 2020
Contributed by Lukas
In this bonus episode, we welcome Drs. Mario Cazzola, Rachel Grace, and Achille Iolascon as they discuss the Blood Review Series on Inherited Anemias....
Season 1, Episode 37
10 Sep 2020
Contributed by Lukas
In this week’s episode, we start by reviewing two studies on the risks of transmitting HIV from transfusion. The first study asks whether changing t...
Season 1, Episode 36
03 Sep 2020
Contributed by Lukas
In this week’s episode, we will learn about vasomotor hyper-responsiveness in sickle cell disease, examine the role of neutrophil extracellular trap...
Season 1, Episode 35
27 Aug 2020
Contributed by Lukas
In this week’s episode, we will review a study that identifies a new modular organization of erythropoiesis and offers a novel strategy to overcome ...
Season 1, Episode 34
20 Aug 2020
Contributed by Lukas
In this week’s episode we will review a study exploring recurrent somatic deletions at chromosome 13q12.2 in acute lymphoblastic leukemia leading to...
Season 1, Episode 33
13 Aug 2020
Contributed by Lukas
In this week’s episode we will review a study exploring the use of demethylating agents in patients with adult T-cell leukemia-lymphoma, learn more ...
Season 1, Episode 32
06 Aug 2020
Contributed by Lukas
In this week’s episode we will review a study exploring the use of a novel hemophilia A mouse model to examine emicizumab function in vivo, a new ap...
Season 1, Episode 31
30 Jul 2020
Contributed by Lukas
In this week's episode we will review a study that demonstrates how the impaired hematopoietic stem cells (HSCs) observed in β-thalassemia can be res...
Season 1, Episode 30
23 Jul 2020
Contributed by Lukas
In this episode we will review a study identifying cyclin-dependent kinase 6 (or CDK6) as a therapeutic target of NUP98-driven acute myeloid leukemia ...
Season 1, Episode 29
16 Jul 2020
Contributed by Lukas
In this episode we’ll review the risk of bleeding after initiating treatment for acquired hemophilia A, examine the functional effect of antibodies ...
Season 1, Episode 28
09 Jul 2020
Contributed by Lukas
This week we’ll review data that suggests the pro-inflammatory environment associated with aging alters hematopoietic stem cell function by inducing...
Season 1, Episode 27
02 Jul 2020
Contributed by Lukas
This week we will explore the impact of calreticulin (or CALR) haploinsufficiency on hematopoietic stem cell activity in the context of myeloprolifera...
Review Series on Secondary Leukemia
02 Jul 2020
Contributed by Lukas
In this bonus podcast episode Dr. Jean Soulier shares highlights of the Blood Review Series on Secondary Leukemia. In this review series, experts prov...
Season 1, Episode 26
25 Jun 2020
Contributed by Lukas
In this week’s episode we’ll examine the cause and clinical significance of dysplastic hematopoiesis at time of diagnosis in patients with multipl...
Season 1, Episode 25
18 Jun 2020
Contributed by Lukas
In this week’s episode we’ll review a study focusing on the causes and impact of the inflammation of aging on hematopoietic stem cell function, le...
Season 1, Episode 24
11 Jun 2020
Contributed by Lukas
In this week’s episode we’ll review results of a trial of venetoclax plus low-dose cytarabine in untreated patients with acute myeloid leukemia wh...
Season 1, Episode 23
04 Jun 2020
Contributed by Lukas
This week’s episode will discuss the impact of sickle cell disease on the bone marrow vascular niche, highlight more about the evolution of retrovir...
Season 1, Episode 22
28 May 2020
Contributed by Lukas
In this week’s episode we will review a report on the use of hydroxyurea as an alternative to transfusion therapy for the prevention of recurrent st...
Season 1, Episode 21
21 May 2020
Contributed by Lukas
Today we’ll review data on the high frequency of germline RUNX1 mutations in patients with acute myeloid leukemia, learn more about the development ...
Season 1, Episode 20
14 May 2020
Contributed by Lukas
In this week’s episode we’ll learn why anticoagulation may play a role in the prevention of vaso-occlusive events in sickle cell disease, review d...
Season 1, Episode 19
07 May 2020
Contributed by Lukas
This week’s episode will review a report on a new mouse model with an enhanced ability to support human hematopoietic and tumor engraftment, explore...
Season 1, Episode 18
30 Apr 2020
Contributed by Lukas
This week’s episode will review the incidence and fate of clonal hematopoiesis among donors and recipients of related allogeneic hematopoietic stem ...
Season 1, Episode 17
23 Apr 2020
Contributed by Lukas
This week’s episode will highlight the development of a factor VIII replacement therapy for patients with severe Hemophilia A, examine a novel pathw...
Review Series on Rare Systemic Hematologic Disorders
16 Apr 2020
Contributed by Lukas
In this bonus podcast episode, Drs. Nancy Berliner and Laurie Sehn lead a discussion on this series of authoritative reviews on a collection of rare s...
Season 1, Episode 16
16 Apr 2020
Contributed by Lukas
This week’s episode will review evidence that selecting donors with specific types of natural killer cells leads to improved outcome in stem cell tr...
Season 1, Episode 15
09 Apr 2020
Contributed by Lukas
This week’s episode will examine data on the impact of the FDG uptake level on predicting subsequent high-grade histological transformation in folli...
Season 1, Episode 14
02 Apr 2020
Contributed by Lukas
In this week’s episode we’ll learn about novel insights into the link between innate immune responses and activation of coagulation during gram-ne...
Season 1, Episode 13
26 Mar 2020
Contributed by Lukas
This week’s episode will review data on spliceosomal gene mutations, evaluate the impact of Ruxolitinib on weight gain, and assess the effect of com...
Season 1, Episode 12
19 Mar 2020
Contributed by Lukas
This week’s episode will review the clinical correlates of NT5C2 mutations in relapsed ALL, the impact of Crovalimab, a recycling monoclonal antibod...
Season 1, Episode 11
12 Mar 2020
Contributed by Lukas
This week’s episode will review a novel treatment for Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis, learn more about the behavio...
Season 1, Episode 10
05 Mar 2020
Contributed by Lukas
This week's episode will explore interventions that may improve outcomes in sepsis by stabilizing neutrophil extracellular traps, or NETs, discuss the...
Review Series on Understanding and Treating Primary Immunodeficiency
27 Feb 2020
Contributed by Lukas
In this episode Dr. Catherine Bollard, Blood Associate Editor provides highlights of this commissioned review series Understanding and Treating Primar...
Season 1, Episode 9
27 Feb 2020
Contributed by Lukas
This week's episode will review efforts to improve the activity of CAR T cells, explore the impact of Protein C activator AB002 on thrombus developmen...
Season 1, Episode 8
20 Feb 2020
Contributed by Lukas
This week’s episode will examine how graft versus host disease in the colon is driven by an inflammatory cytokine produced by specialized donor T ce...
Season 1, Episode 7
13 Feb 2020
Contributed by Lukas
This week’s episode will review treatment for secondary prevention of venous thromboembolism in children, a therapeutic strategy for relapsed or ref...
Season 1, Episode 6
06 Feb 2020
Contributed by Lukas
This week’s episode will examine the critical role of platelet necrosis in ischemic stroke injury, the discovery of the molecular basis for the PEL ...
Review Series on Treatment of Venous Thrombotic Disorders
31 Jan 2020
Contributed by Lukas
In this episode we welcome Drs. Thomas Ortel, Jeffrey Weitz, and Kenneth Bauer as they discuss the Blood Review Series on the Treatment of Venous Thro...
Season 1, Episode 5
30 Jan 2020
Contributed by Lukas
In this episode we’ll examine a new strategy to improve the durability of remission after CAR T-cell therapy for pediatric B cell leukemia, explore ...
Season 1, Episode 4
23 Jan 2020
Contributed by Lukas
Today we’ll examine the role of heredity vs. environmental factors in the evolution of age-related clonal hematopoiesis, review the first system...
Season 1, Episode 3
16 Jan 2020
Contributed by Lukas
In this episode we highlight the development of intensified T-cell acute lymphoblastic leukemia-focused protocols, the use of a thrombopoietin agonist...
Season 1, Episode 2
09 Jan 2020
Contributed by Lukas
This episode will explore the consequences of a loss of the interaction between mutant calreticulin and another ER resident protein, and how this may ...
Season 1, Episode 1
02 Jan 2020
Contributed by Lukas
This episode will highlight a unique treatment for refractory hematologic malignancies, therapy-induced mutations impacting the genomic landscape of r...
Sneak Peek Episode 2
10 Dec 2019
Contributed by Lukas
This episode highlights articles and commentaries that help expand our understanding of prognostic biomarkers in CLL, learn more about a streamlined a...
Sneak Peek Episode 3
10 Dec 2019
Contributed by Lukas
This episode discusses the immune engine in classical Hodgkin Lymphoma, osteopontin’s keyrole in the chemoattraction of neutrophils in transfusion-r...
Sneak Peek Episode 4
10 Dec 2019
Contributed by Lukas
The topics in this episode include studies on the mechanism of progression in myelodysplastic syndromes, the value of gait speed as a predictor of out...
Sneak Peek Episode 1
10 Dec 2019
Contributed by Lukas
This episode explores four compelling topics which include: Hemophagocytic Lymphohistiocytosis, a severe and potentially fatal systemic inflammatory s...
Blood Podcast - Trailer
09 Nov 2019
Contributed by Lukas
The article highlighted in this trailer "The chromatin-binding protein Phf6 restricts the self-renewal of hematopoietic stem cells" was published Ju...