Why does Benadryl make us sleepy?

#203 In this episode, Jam recounts a humorous yet enlightening story of accidentally taking a dog-sized dose of Benadryl and the sleepy consequences that followed. Melissa, a chemist, dives deep into the chemistry of antihistamines, explaining the difference between first-generation (drowsy) and second-generation (non-drowsy) antihistamines. The episode covers the role of histamine in the body's allergic reactions and how different antihistamines interact with histamine receptors. Melissa elucidates the chemical structures of these medicines and how their polarity affects their ability to cross the blood-brain barrier, ultimately influencing whether they cause drowsiness. 00:00 A Benadryl Mishap 02:12 Understanding Antihistamines 03:28 The Science Behind Benadryl 04:55 How Antihistamines Work 10:41 Non-Drowsy Antihistamines 18:29 Personal Allergy Experiences 27:52 Allergy Medication Preferences 35:11 Supporting the Show Thanks to our monthly supporters Julie S Heather R Autoclave Chelsea M Dorien V Scott B Jessie R Ciara L J0HNTR0Y Jeannette N Cullyn R Erica B Elizabeth P Sarah M Rachel R Letila Katrina B Suzanne P Venus R Lyn S Jacob T Brian K Emerson W Kristina G Timothy P Steven B Chris and Claire S Chelsea B Avishai B Hunter R ★ Support this podcast on Patreon ★ ★ Buy Podcast Merch and Apparel ★ Check out our website at chemforyourlife.com Watch our episodes on YouTube Find us on Instagram, Twitter, and Facebook @ChemForYourLife Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

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