DDT Method Podcast
The Mitochondria Enhancement Debate! - with Alex Kikel and Anthony Castore
28 Jul 2025
TOP TAKEAWAYS:Why combining BAM15 + SLU-PP-332 could be sabotaging your resultsThe "start low, go slow" protocol that prevents mitochondrial damageHow to structure fasting + refeed cycles for maximum fat lossAdvanced supplementation strategies for 40+ professionalsThe critical difference between structure and function optimizationIn this landmark 2-hour debate, mitochondrial experts Anthony Castore and Alex Kikel dive deep into the controversial combination of BAM15 and SLU-PP-332. This isn't your typical supplement discussion ā it's a masterclass in advanced optimization for experienced athletes and high-performing professionals.This episode breaks down the complex world of mitochondrial enhancement, covering everything from basic cellular structure to cutting-edge peptide protocols. Anthony and Alex present different perspectives on combining these powerful compounds, with one advocating for separation and strategic timing, while the other supports careful low-dose combination approaches.CHAPTER BREAKDOWN:Mitochondrial Membrane Potential & HyperpolarizationThe Structure-Function Relationship in Cellular OptimizationBAM15: Uncoupling for Fat Loss and Cognitive EnhancementSLU-PP-332: PGC1-Alpha Activation and Mitochondrial BiogenesisCombination Protocols: Benefits vs. RisksAdvanced Fasting + Refeed StrategiesSupporting Supplement Stacks for Maximum SafetyReal-World Application for Different PopulationsKEY PROTOCOLS DISCUSSED:24-hour fast to refeed optimization sequenceTraining day vs. rest day compound timingDosage titration strategies (100mcg-50mg ranges)Biomarker tracking for safety monitoringPolypharmacy considerations for TRT usersIMPORTANT DISCLAIMER: This content is for educational purposes only. These are research compounds without human safety studies. Always consult healthcare professionals before implementing any protocols discussed.
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