Welcome to "From Our Neurons to Yours," from the Wu Tsai Neurosciences Institute at Stanford University. Each week, we bring you to the frontiers of brain science — to meet the scientists unlocking the mysteries of the mind and building the tools that will let us communicate better with our brains.This week, we're tackling a BIG question in neuroscience: why do we do what we do? Specifically, we're talking about dopamine, and why the common understanding of this molecule as a "pleasure chemical" in the brain may be missing something fundamental. Join us as we explore the distinction between 'liking' and 'wanting', between reward and motivation, and how this could help us more deeply understand how dopamine shapes our behavior. Tune in to gain insights into addiction, Parkinson's disease, depression and more. Don't miss out on this thought-provoking discussion with Neir Eshel, a psychiatrist and leading Stanford expert on dopamine and behavior. (Including a conversation about a recent paper published with Rob Malenka, who we spoke with back in our very first episode!)Learn MoreEshel Lab websiteStanford Medicine study reveals why we value things more when they cost us more (Stanford Medicine, 2023)Striatal dopamine integrates cost, benefit, and motivation (Eshel et al., Neuron, 2024)The Economics of Dopamine Release (Stanford BioX Undergraduate Summer Research Program lecture)Youtube video of classic James Olds rat brain stimulation studyEpisode CreditsThis episode was produced by Michael Osborne at 14th Street Studios, with production assistance by Morgan Honaker. Our logo is by Aimee Garza. The show is hosted by Nicholas Weiler, at Stanford's Wu Tsai Neurosciences Institute. Send us a text!Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience. We want to hear from your neurons! Email us at at [email protected] Learn more about the Wu Tsai Neurosciences Institute at Stanford and follow us on Twitter, Facebook, and LinkedIn.

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