JAMA Clinical Reviews
Episodes
Hepatitis B: Global Insights on Transmission and Treatment
04 May 2026
Contributed by Lukas
Hepatitis B virus (HBV) infection affects around 254 million people worldwide and causes more than 1 million deaths annually. Author Anna Lok, MD, fro...
Review of Cardiac Resynchronization Therapy
27 Apr 2026
Contributed by Lukas
Heart failure (HF) affects more than 64 million individuals worldwide, and 20% to 30% of patients with HF and systolic dysfunction have cardiac dyssyn...
Prepregnancy Care and Counseling to Improve Maternal and Neonatal Outcomes
20 Apr 2026
Contributed by Lukas
In the US, approximately 66% of reproductive-aged women have at least 1 modifiable risk factor for adverse pregnancy outcomes. Authors and ob-gyns Kyl...
Diagnosis and Management of Endometrial Cancer
13 Apr 2026
Contributed by Lukas
Endometrial cancer accounts for 95% of uterine cancers, which are the fourth most common cancer in women in the US. Author Karen McLean, MD, PhD, of R...
Evaluating for Pediatric Concussion
06 Apr 2026
Contributed by Lukas
Explore evidence-based clinical signs, diagnostic accuracy, and practical assessment strategies to optimize care with an in-depth look at the latest i...
Iron Deficiency in Adults: Advances in Diagnosis and Treatment
30 Mar 2026
Contributed by Lukas
Absolute iron deficiency with or without anemia affects about 2 billion people worldwide and 14% of adults in the US. Discover causes, diagnosis, and ...
From the JAMA Network: Incidental Rotator Cuff Abnormalities on Magnetic Resonance Imaging
28 Mar 2026
Contributed by Lukas
Interview with Thomas Ibounig, MD, author of Incidental Rotator Cuff Abnormalities on Magnetic Resonance Imaging and Brian T. Feeley, MD, author of Ma...
Resistant Hypertension: Diagnosis and Management
23 Mar 2026
Contributed by Lukas
Resistant hypertension affects about 10% of those treated for hypertension. Managing it involves lowering sodium intake, exercising, losing weight, re...
Update on Peanut Allergy
19 Mar 2026
Contributed by Lukas
Peanut allergy affects about 2% of people in the US and most commonly develops in early childhood. Peanut introduction during infancy has led to decre...
Obesity-Related Cancer
09 Mar 2026
Contributed by Lukas
Overweight and obesity may cause 10% of new cancer diagnoses annually in the US. In this JAMA Review in the Translational Science series, author Neil ...
Diagnosis and Treatment of Chronic, Noninfectious Diarrhea
02 Mar 2026
Contributed by Lukas
Chronic noninfectious diarrhea affects approximately 6% to 7% of adults in the US and significantly impairs quality of life. Author William Chey, MD, ...
Does This Patient Have Volume Overload? The Rational Clinical Examination
23 Feb 2026
Contributed by Lukas
Accurate assessment of intravascular volume facilitates decisions about fluid management in patients with volume overload. Author Edmund A. Liles Jr, ...
Type 1 Diabetes: Diagnosis and Management
16 Feb 2026
Contributed by Lukas
Type 1 diabetes affects approximately 2 million people in the US and 8.4 million people worldwide. Author Desmond Schatz, MD, of the University of Flo...
Pharmaceutical Pricing: JAMA Talks With Mark Cuban
12 Feb 2026
Contributed by Lukas
Mark Cuban, entrepreneur, investor, and cofounder of the Mark Cuban Cost Plus Drug Company, joins JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, M...
Medications for Opioid Use Disorder, Withdrawal, and Overdose
11 Feb 2026
Contributed by Lukas
Opioid use disorder is the third most prevalent substance use disorder worldwide. Author Alexander Walley, MB, MSc, of Boston Medical Center and Bosto...
Ovarian Cancer Prevention With Opportunistic Fallopian Tube Removal
02 Feb 2026
Contributed by Lukas
Ovarian cancer may be prevented with removal of the fallopian tubes during pelvic or select abdominal surgery in eligible women. This procedure, oppor...
IgA Nephropathy in Adults
26 Jan 2026
Contributed by Lukas
IgA nephropathy is a chronic kidney disease involving deposition of IgA-containing immune complexes in the glomerulus, which often causes kidney failu...
Restless Legs Syndrome
21 Jan 2026
Contributed by Lukas
Restless legs syndrome is a sleep-related neurologic disorder that causes an overwhelming urge to move the limbs, which can cause substantial sleep di...
A Conversation About the FDA's Regulation of Mifepristone
12 Jan 2026
Contributed by Lukas
Mifepristone used with misoprostol is the most common abortion regimen in the US. It is also a focal point of reproductive health policy and politics,...
Gastric Cancer Worldwide
07 Jan 2026
Contributed by Lukas
Incidence rates of gastric cancer in younger individuals are on the rise and gastric cancer is the fifth-leading cause of cancer-related deaths worldw...
JAMA Editors' Choice 2025: Clinical Reviews Podcasts
30 Dec 2025
Contributed by Lukas
JAMA Deputy Editor Mary McDermott, MD, and JAMA Deputy Editor Kristin Walter, MD, MS, highlight their selections of top JAMA Clinical Reviews podcasts...
From the JAMA Network: JAMA Research of the Year With Editor in Chief Kirsten Bibbins-Domingo
26 Dec 2025
Contributed by Lukas
In this episode, JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, and Medical News Director Jennifer Abbasi discuss the journal's inaugural...
WHO Guideline on the Use and Indications of GLP-1 Therapies for the Treatment of Obesity in Adults
17 Dec 2025
Contributed by Lukas
Obesity affects more than 1 billion people worldwide and is recognized by the World Health Organization as a chronic, relapsing disease. WHO recently ...
Head and Neck Cancer
15 Dec 2025
Contributed by Lukas
Head and neck cancer is the seventh most common cancer worldwide and is commonly associated with tobacco and alcohol use, or human papillomavirus (HPV...
How Climate Change Affects Allergic Rhinitis and Sinusitis
03 Dec 2025
Contributed by Lukas
Allergic rhinitis affects about 1 in 6 US adults. A recent JAMA Insights summarizes evidence regarding the associations of climate change and air poll...
Cannabis and Cannabinoids for Therapeutic Purposes
26 Nov 2025
Contributed by Lukas
Clinicians should weigh benefits against risks when engaging patients in informed discussions about cannabis or cannabinoid use. Kevin Hill, MD, MHS, ...
Diagnosis and Treatment of Peripheral Neuropathy
17 Nov 2025
Contributed by Lukas
Peripheral neuropathy affects approximately 1% of adults worldwide and can be associated with significant disability. Author Michelle Mauermann, MD, o...
Diagnosis and Treatment of MASLD
10 Nov 2025
Contributed by Lukas
Metabolic dysfunction-associated steatotic liver disease (MASLD), an increasingly prevalent condition among adults worldwide, is associated with liver...
Moving Toward a Safer World by 2040
03 Nov 2025
Contributed by Lukas
The JAMA Summit on Firearm Violence convened 60 thought leaders from a wide array of disciplines to chart a roadmap that could lead to substantial red...
Treatment of Keratinocyte Carcinoma
30 Oct 2025
Contributed by Lukas
Keratinocyte carcinomas, which include basal cell carcinoma and squamous cell carcinoma, are common forms of skin cancer. Approximately 5.4 million ke...
Lung Cancer in Nonsmoking Individuals
20 Oct 2025
Contributed by Lukas
Lung cancer in nonsmoking individuals is increasing worldwide and currently accounts for 15% to 20% of lung cancer cases globally. Benjamin Solomon, P...
What Clinicians Should Know About Syphilis
16 Oct 2025
Contributed by Lukas
Syphilis infections have increased in the US and worldwide over the past decade. Left untreated, syphilis can cause blindness, deafness, psychosis, de...
Microplastic Pollution and Human Health
15 Oct 2025
Contributed by Lukas
Microplastics, defined as plastics smaller than 5 mm, have been detected in human tissues at increasing rates and are associated with potential advers...
Treatment of Severe Refractory Asthma
01 Oct 2025
Contributed by Lukas
Severe refractory asthma, which affects approximately 1% to 5% of patients with asthma, is associated with increased morbidity and mortality. Author J...
From the JAMA Network: Acetaminophen Use in Pregnancy and Risk of Autism
30 Sep 2025
Contributed by Lukas
Epidemiologist Brian Lee, PhD, discusses his study on acetaminophen use during pregnancy and children's risk of autism and other neurodevelopmental di...
Five Things to Do When Communicating Medical Numbers
24 Sep 2025
Contributed by Lukas
Health care professionals often use numbers to guide decisions, monitor patient health, and communicate information. Author Angela Fagerlin, PhD, of t...
Superficial Vein Thrombosis
15 Sep 2025
Contributed by Lukas
Superficial vein thrombosis (SuVT) is characterized by thrombus formation in the superficial veins, typically in the lower or upper extremities. In th...
Diagnosis and Management of Hypothyroidism
03 Sep 2025
Contributed by Lukas
Untreated hypothyroidism can cause serious health complications such as heart failure and myxedema coma. Author Maria Papaleontiou, MD, of the Univers...
From the JAMA Network: Over-the-Counter Hearing Aid–Enabled Earbuds
29 Aug 2025
Contributed by Lukas
Interview with Alexander Chern, MD, author of Over-the-Counter Hearing Aid–Enabled Earbuds—Merging Hearing Health and Technology. Hosted by Paul C...
Diagnosis and Management of Cutaneous Melanoma
25 Aug 2025
Contributed by Lukas
The incidence and prevalence of cutaneous melanoma in the US and worldwide have increased over the last 5 decades. JAMA Review Author John Kirkwood, M...
Diagnosis and Treatment of Hemorrhoidal Disease
18 Aug 2025
Contributed by Lukas
Hemorrhoidal disease, pathology of the tissue lining the anal canal, affects approximately 10 million individuals in the US. Author Jean H. Ashburn, M...
Treatment of Complicated Staphylococcus aureus Bacteremia
13 Aug 2025
Contributed by Lukas
Dalbavancin, a long-acting IV lipoglycopeptide, may be an option for the treatment of complicated Staphylococcus aureus bacteremia without requiring l...
Diagnosis and Management of Prostatitis
11 Aug 2025
Contributed by Lukas
Prostatitis affects approximately 9.3% of men in their lifetime and includes acute and chronic bacterial infection and nonbacterial chronic prostatiti...
Geroscience in Medicine
07 Aug 2025
Contributed by Lukas
Geroscience aims to define and modify biologic pathways associated with aging and age-related diseases. Author Stephen B. Kritchevsky, PhD, of the Wak...
Managing Adverse Effects of Obesity Medications
29 Jul 2025
Contributed by Lukas
New medications for obesity, such as semaglutide and tirzepatide, are highly effective but can be associated with adverse effects that reduce adherenc...
Patent Foramen Ovale-Associated Stroke
28 Jul 2025
Contributed by Lukas
A patent foramen ovale (PFO) is present in approximately 25% of all adults. Author David M. Kent, MD, MS, of Tufts Medical Center and JAMA Associate E...
Diverticulitis: Diagnosis and Management
24 Jul 2025
Contributed by Lukas
Approximately 200 000 people are hospitalized for diverticulitis each year in the US, and the incidence of diverticulitis is increasing, particularly ...
Ovarian Cancer: Clinical Risk Factors and Treatment
21 Jul 2025
Contributed by Lukas
A recent Review discusses the epidemiology, risk factors, diagnosis, and treatment of ovarian cancer. William Cliby, MD, and John Weroha, MD, PhD, bot...
Early-Onset Gastrointestinal Cancers
17 Jul 2025
Contributed by Lukas
Early-onset gastrointestinal cancers, typically defined as occurring in patients younger than age 50, are increasing worldwide. A recent JAMA Review s...
Managing Lower Urinary Tract Symptoms in Men
14 Jul 2025
Contributed by Lukas
Approximately 40% of men older than 50 have urinary frequency or urgency that affects their quality of life. Author John T. Wei, MD, MS, of the Univer...
West Nile Virus
07 Jul 2025
Contributed by Lukas
In the 25 years since its emergence in the US, West Nile virus has become the leading cause of domestic mosquito-borne disease. It causes approximatel...
Treatment and Management of Osteoporosis
30 Jun 2025
Contributed by Lukas
Worldwide, 1 in 3 women and 1 in 5 men older than 50 years experience osteoporotic fractures in their lifetime. Author Suzanne N. Morin, MD, MSc, of M...
Type 2 Diabetes: Diagnosis and Current Guidelines for Treatment
23 Jun 2025
Contributed by Lukas
Which tests can be used to diagnose type 2 diabetes? When should injectable medications for type 2 diabetes be started? These are just some of the que...
Adrenal Insufficiency in Adults
16 Jun 2025
Contributed by Lukas
Adrenal insufficiency is a syndrome of cortisol deficiency. A recent JAMA Review summarizes the pathophysiology, diagnosis, and treatment of adrenal i...
From the JAMA Network: Comprehensive Review of Foley Catheter Management
12 Jun 2025
Contributed by Lukas
Interview with Anne P. Cameron, MD and Glenn T. Werneburg, MD, PhD, authors of Foley Catheter Management: A Review. Hosted by Amalia Cochran, MD. Rel...
How to Improve Patients' Treatment Expectations
04 Jun 2025
Contributed by Lukas
Patients' treatment expectations may affect their treatment outcomes. Coauthor Johannes A. C. Laferton, PhD, joins JAMA Senior Editor Anne Cappola, MD...
Lipoprotein(a): What Clinicians Should Know
03 Jun 2025
Contributed by Lukas
Elevated levels of lipoprotein(a) are associated with higher rates of cardiovascular events. Author Samia Mora, MD, MHS, of Brigham and Women's Hospit...
Platelet Transfusion: Best Practice Guidelines
29 May 2025
Contributed by Lukas
A central question in platelet transfusion is whether to follow a restrictive or liberal strategy in decisions about which patients should receive pla...
Immune Thrombotic Thrombocytopenic Purpura (iTTP)
19 May 2025
Contributed by Lukas
Immune thrombotic thrombocytopenic purpura (iTTP) is a rare coagulopathic disorder characterized by immune-mediated thrombocytopenia and microangiopat...
Microbiome and Risk for Cancer Outcomes
12 May 2025
Contributed by Lukas
The human microbiome appears to influence risk for development and progression of cancer and response to treatment. Author Jennifer Wargo, MD, Univers...
Diagnosis and Treatment of Endometriosis
05 May 2025
Contributed by Lukas
Endometriosis, a common cause of pelvic pain, affects approximately 10% of reproductive-age females. Author Sawsan As-Sanie, MD, MPH, University of Mi...
Strategies for Talking With Parents About Vaccines
30 Apr 2025
Contributed by Lukas
What is the single most important thing to recognize when communicating with families about vaccines? Author Sean T. O'Leary, MD, MPH, of the Universi...
Non–Cystic Fibrosis (CF) Bronchiectasis in Adults
28 Apr 2025
Contributed by Lukas
Non-cystic fibrosis (CF) bronchiectasis, which affects approximately a half million people in the US, is a chronic lung condition that involves perman...
Vitamin D Guidelines for Healthy Children and Adults
23 Apr 2025
Contributed by Lukas
A JAMA Clinical Guidelines Synopsis summarizes the Endocrine Society's most recent recommendations on vitamin D supplementation for disease prevention...
Discussing Surgery With Patients
16 Apr 2025
Contributed by Lukas
What are 3 fundamental communication skills needed when discussing surgery with patients? Author Lauren J. Taylor, MD, of the Central Virginia VA Heal...
Treatment of Small Cell Lung Cancer
31 Mar 2025
Contributed by Lukas
Small cell lung cancer (SCLC) is a smoking-related malignancy that presents at an advanced stage in 70% of patients. Author Anne C. Chiang, MD, PhD, o...
Diagnosis, Treatment, and Prognosis of Autosomal Dominant Polycystic Kidney Disease (ADPKD) in Adults
24 Mar 2025
Contributed by Lukas
Polycystic kidney disease is the most common genetic kidney disease worldwide and is characterized by progressive development of kidney cysts. Author ...
Chronic Myeloid Leukemia: A Review
17 Mar 2025
Contributed by Lukas
Chronic myeloid leukemia is a myeloproliferative neoplasm that affects approximately 5 million people worldwide. Tyrosine kinase inhibitors, such as i...
USPSTF Recommendation: Screening for Food Insecurity
11 Mar 2025
Contributed by Lukas
Interview with Tumaini Rucker Coker, MD, MBA, USPSTF member and coauthor of Screening for Food Insecurity: US Preventive Services Task Force Recommend...
Localized and Metastatic Prostate Cancer
10 Mar 2025
Contributed by Lukas
Prostate cancer is the most common nonskin cancer in men in the US and the second most common cancer in men worldwide. Author R. Bruce Montgomery, MD,...
Eating Disorders: A Review
06 Mar 2025
Contributed by Lukas
A recent JAMA article reviews the 3 most common eating disorders, their risk factors, diagnosis and treatment. In this podcast, coauthors Evelyn Attia...
A New Legal Standard for Medical Malpractice From the American Law Institute
26 Feb 2025
Contributed by Lukas
In 2024, the American Law Institute revised the legal standard for assessing medical negligence. Author Christopher T. Robertson, JD, PhD, of Boston U...
Sudden Cardiac Arrest in Healthy Young Adults
20 Feb 2025
Contributed by Lukas
Out-of-hospital cardiac arrest in apparently healthy adults younger than 40 years ranges from 4 to 14 per 100 000 person-years worldwide. Among young ...
Pulmonary Rehabilitation Guidelines for Adults With Chronic Respiratory Disease
05 Feb 2025
Contributed by Lukas
Guidelines from the American Thoracic Society report on the value of pulmonary rehabilitation for people with COPD, interstitial lung disease, or pulm...
Essential Thrombocythemia
27 Jan 2025
Contributed by Lukas
Essential thrombocythemia, a clonal myeloproliferative neoplasm with excessive platelet production, is associated with an increased risk of thrombosis...
USPSTF Recommendation: Screening for Osteoporosis to Prevent Fractures
14 Jan 2025
Contributed by Lukas
Interview with Esa M. Davis, MD, MPH, USPSTF member and coauthor of Screening for Osteoporosis to Prevent Fractures: US Preventive Services Task Force...
Recent Developments in Women's Health Research at the NIH
06 Jan 2025
Contributed by Lukas
NIH'S policies, programs, and research funding fill gaps in knowledge about women's health. Janine Austin Clayton, MD, of the NIH joins JAMA Editor in...
JAMA Editors' Choice 2024: Clinical Reviews Podcasts
02 Jan 2025
Contributed by Lukas
JAMA Deputy Editor Mary McDermott, MD, and JAMA Deputy Editor Kristin Walter, MD, MS, highlight their selections of top JAMA 2024 Clinical Reviews pod...
Chronic Kidney Disease and Diabetes
26 Dec 2024
Contributed by Lukas
Chronic kidney disease develops among 30% to 40% of people with type 1 or type 2 diabetes during their lifetime. Author Ian H. de Boer, MD, MS, of the...
Diagnosis and Treatment of Atrial Fibrillation
16 Dec 2024
Contributed by Lukas
The number of people living with atrial fibrillation (AF) is increasing, and they have a higher rate of cardiovascular events, chronic kidney disease,...
Allogeneic Stem Cell Donation
11 Dec 2024
Contributed by Lukas
Allogeneic stem cell transplantation is a potentially life-saving therapy for some patients with hematologic and bone marrow cancers and certain nonma...
JAMA Research at Critical Care Reviews 2024 (CCR Down Under)
11 Dec 2024
Contributed by Lukas
JAMA Senior Editor Derek Angus, MD, MPH, and JAMA Associate Editor Christopher Seymour, MD, MSc, discuss 4 critical care trials published in JAMA and ...
Loss of Obstetric Care in Rural and Urban Hospitals in the US
04 Dec 2024
Contributed by Lukas
Access to obstetric care in US hospitals has been declining, while maternal mortality is on the rise. A new research letter published in JAMA quantifi...
Ovarian Aging
26 Nov 2024
Contributed by Lukas
Ovarian aging is an important cause of infertility in women older than 35 years. Success rates of fertility treatment decline with age, most commonly ...
Mpox Treatment Strategies, Clinical Presentation, and Diagnostic Approaches
19 Nov 2024
Contributed by Lukas
Mpox is an evolving global health threat, and clinicians should be aware of characteristic signs and symptoms to ensure timely diagnosis and appropria...
Calcific Aortic Stenosis: Symptoms, Diagnosis, and Treatment
11 Nov 2024
Contributed by Lukas
Calcific aortic stenosis affects approximately 12% of people 75 years in the US and worldwide leads to more than 100 000 deaths each year. Catherine M...
CAR T Cells and T-Cell Therapies for Cancer
04 Nov 2024
Contributed by Lukas
CAR T cells are genetically engineered to express a receptor that recognizes and kills tumor cells. CAR T-cell products are now FDA approved for 6 hem...
Diagnosis and Treatment of Peptic Ulcer Disease
28 Oct 2024
Contributed by Lukas
Peptic ulcer disease affects approximately 1% of the population in the US, and H pylori is a common cause of peptic ulcer disease. Author Nimish Vakil...
Strategies for Helping Patients Navigate High Prescription Drug Costs
21 Oct 2024
Contributed by Lukas
High prescription costs are a major barrier to the optimal treatment of many health conditions. Prescribers need tools to help patients find the lowes...
Preexposure Prophylaxis (PrEP) Options for HIV
14 Oct 2024
Contributed by Lukas
Even though highly effective medications are currently available to prevent HIV, there are about 1.3 million new infections worldwide each year. Monic...
Update on Over-the-Counter (OTC) Contraception
09 Oct 2024
Contributed by Lukas
In July 2023, the US Food and Drug Administration (FDA) approved Opill, a daily progestin-only oral contraceptive for over-the-counter sale to people ...
Dialysis for Chronic Kidney Failure
02 Oct 2024
Contributed by Lukas
Selection of hemodialysis or peritoneal dialysis and timing of dialysis initiation are influenced by patient symptoms, laboratory trajectories, patien...
Diagnosis and Treatment of Chronic Spontaneous Urticaria
26 Sep 2024
Contributed by Lukas
Chronic spontaneous urticaria affects approximately 1% of the general population worldwide, impairs patients' quality of life, and is associated with ...
Diagnosis and Treatment of Community-Acquired Pneumonia (CAP)
16 Sep 2024
Contributed by Lukas
Community-acquired pneumonia is associated with approximately 740 000 hospitalizations and 41 000 deaths in the US annually. JAMA Review authors Scott...
Scabies, Bedbug, and Body Lice Infestations
09 Sep 2024
Contributed by Lukas
Infestations by ectoparasites such as scabies, bedbugs, and body lice are common. Diagnosis requires history, including social drivers of health such ...
Acute Pericarditis
05 Sep 2024
Contributed by Lukas
Pericarditis accounts for up to 5% of emergency department visits for nonischemic chest pain in North America and Western Europe. JAMA Review author P...
JAMA Highlights From ESC 2024
02 Sep 2024
Contributed by Lukas
JAMA Editor in Chief Kirsten Bibbins-Domingo reviews 4 JAMA trials presented at this year's European Society of Cardiology (ESC) Congress on antihyper...
Renal Cell Carcinoma
28 Aug 2024
Contributed by Lukas
Renal cell carcinoma has an estimated lifetime prevalence of 2.3% for men and 1.3% for women in the US. Affected patients in early stages can have 94%...
USPSTF Recommendation: Iron Deficiency During Pregnancy
20 Aug 2024
Contributed by Lukas
Interview with Esa M. Davis, MD, MPH, USPSTF member and coauthor of Screening and Supplementation for Iron Deficiency and Iron Deficiency Anemia Durin...
Diagnosis, Treatment, and Prevention of Genital Herpes
14 Aug 2024
Contributed by Lukas
Genital herpes is a common sexually transmitted infection that is caused by HSV-1 or HSV-2 and may result in ulcers, neonatal herpes infection, and in...