Mastering Nutrition

Depression Starts In Your Mitochondria

15 Dec 2025

Contributed by Lukas

You could be one metabolic bottleneck away from feeling amazing. Mitome is the first at-home test that measures your cellular energy directly and give...

Aging is best explained by declining mitochondrial function over time.

09 Dec 2025

Contributed by Lukas

  Aging is best explained by declining mitochondrial function over time.   This answers its own "why."   Mitochondria produce the energy neede...

The Medical Myth That Nutritional Deficiencies Are A Thing of the Past

07 Dec 2025

Contributed by Lukas

This is a clip from Joe Rogan Experience JRE 2420.  Watch the full interview here: https://www.youtube.com/watch?v=QBn54YNnKD0

Why Doctors Think They Can Ignore the Studies Suggesting Seed Oils Cause Heart Disease

07 Dec 2025

Contributed by Lukas

This is a clip from Joe Rogan Experience JRE 2420. Watch the full interview here: https://www.youtube.com/watch?v=QBn54YNnKD0

The Problem With Seed Oils and Why They Are So Controversial

05 Dec 2025

Contributed by Lukas

This is a clip from Joe Rogan Experience Episode 2420. You can watch the full interview here: https://www.youtube.com/watch?v=QBn54YNnKD0

Mitochondria: Why They Control Everything in Human Health

04 Dec 2025

Contributed by Lukas

Mitochondria govern everything. Watch this with the slides here: https://www.youtube.com/watch?v=mED1_L3wZbc Mitochondria convert your food to usable ...

SSRI Withdrawal Is Mitochondrial Dysfunction

23 Nov 2025

Contributed by Lukas

Chris Masterjohn, PhD, Founder and Scientific Director of mito.me, explains why SSRI withdrawal is mitochondrial dysfunction and what to do about it. ...

How Lactate Alkalinizes Your Muscles

06 Sep 2024

Contributed by Lukas

For a long time, most people believed that when we exercise, our muscles make lactic acid, this acidifies the muscles, and the acidity contributes to ...

D-Lactate: Groundbreaking Research No One Is Talking About

31 Jul 2024

Contributed by Lukas

D-lactate is commonly stated to be exclusively a microbial metabolite.  This is found in assumptions within the medical literature for decades even w...

Handling Creatine Side Effects

12 Jul 2024

Contributed by Lukas

In this podcast we cover elevated creatinine, insomnia, cramps constipation, water retention, hair loss, irritation and anger, lightheadedne...

Your Cells Are Starving For Creatine

12 Jul 2024

Contributed by Lukas

Creatine is like your second mitochondria. Or, the mitochondria’s chief of staff. Or its co-pilot. Your mitochondria make ATP so you can see clearly...

Is Whole Food Vitamin C Really Different? | Masterjohn Q&A Files #330

18 Dec 2023

Contributed by Lukas

Question: Is whole food vitamin C superior to natural because it is part of a tyrosinase complex? Short Answer: Vitamin C is nearly ubiquitously distr...

What's the Deal With Seed Oils? | Masterjohn Q&A Files #329

04 Dec 2023

Contributed by Lukas

Question: What Is the Real Issue With Seed Oils? Short Answer: The main issue with seed oils is that they present an oxidative liability. They do not...

Is Hair Mineral Testing Useful? | Masterjohn Q&A Files #328

20 Nov 2023

Contributed by Lukas

Question: How useful is hair trace mineral analysis (HTMA) for nutritional testing? Short Answer: Hair trace mineral analysis is included as an option...

Secrets to Superior Cognitive Performance (Without Drugs)

17 Nov 2023

Contributed by Lukas

Nutrition is far more powerful than drugs to improve cognitive performance. We start by looking at cocaine, Adderall, and Ritalin, and show why these ...

Vitamin C, Whole Food Vs. Synthetic: Does It Matter?

16 Nov 2023

Contributed by Lukas

Debunking the myth that vitamin C in plants is found in a special "tyrosinase complex." For the written article with references, see here: https://ch...

Fact-Checking Gary Brecka on Rogan: A Deep Dive into MTHFR and Methylation

14 Nov 2023

Contributed by Lukas

Watch or listen to the full critique here: https://www.youtube.com/watch?v=kMPvCiOkEtQ

Cancer, IV Drips, and the Glutathione Vitamin C Connection

06 Nov 2023

Contributed by Lukas

Is high-dose vitamin C good for you?   High-dose intravenous vitamin C can selectively kill cancer cells in live patients and can save sepsis patient...

How to Find the Root Cause of Autoimmunity? | Masterjohn Q&A Files #327

06 Nov 2023

Contributed by Lukas

Question: How to Find the Root Cause of Autoimmunity? Short Answer: Autoimmune conditions are likely driven by deficiencies of vitamins A and D, whic...

The Powerful Duo: How Glutathione and Vitamin C IV Drips Impact Cancer

01 Nov 2023

Contributed by Lukas

High-dose intravenous (IV) vitamin C has the potential to kill cancer cells and prolong the survival of terminal cancer patients. This podcast is a pr...

Startled?! Try Glycine!

28 Oct 2023

Contributed by Lukas

The ability to become startled is an adaptive behavior that protects us from being injured by a sudden threat, and prepares us for the fight-or-flight...

Hormones Are Never In Charge

27 Oct 2023

Contributed by Lukas

Hormones matter, but they are never in charge. Their abnormalities are never the root cause of anything. All hormones do is communicate the biochemist...

Biotin’s Health Benefits: Way Beyond Hair and Nails

26 Oct 2023

Contributed by Lukas

Most people who take biotin take it for their hair and nails. Yet biotin does much more than this. Learn what to use it for, how much to take, and how...

Exposing Harmful Supplements: Biotin's Dark Side

24 Oct 2023

Contributed by Lukas

This is how to use a simple home measurement to expose the harmful effects of a supplement before they even happen. Read the article here: https://ch...

Why Would Vitamin C cause muscle pain, joint pain, and brain fog? | Masterjohn Q&A Files #326

23 Oct 2023

Contributed by Lukas

Question: Why Would Vitamin C cause muscle pain, joint pain, and brain fog? Short Answer: Acutely, vitamin C would likely cause these effects by gene...

Why You Need THIS Supplement On a High-Protein Diet: Game-Changing Effects Explained by a PhD

18 Oct 2023

Contributed by Lukas

If you are eating a high-protein diet, you probably aren’t getting enough biotin. This is especially true if you are a protein-fueled athlete and fi...

Why High-Dose Biotin Could be the Answer for Your Blood Sugar, Brains, and Beauty

18 Oct 2023

Contributed by Lukas

The use of high-dose biotin supplements has increased almost 30-fold over the last twenty years for such problems as diabetes, smell and taste disorde...

A PhD's Secret Weapon: The Four Biomarkers Every Expert Should, But Doesn’t, Analyze

13 Oct 2023

Contributed by Lukas

The most useful tests are the ones no one ever orders. This podcast is available for free for 48 hours, and then will only be available to Masterpass ...

Can NAC hurt your gut health? | Masterjohn Q&A Files #325

09 Oct 2023

Contributed by Lukas

Question: Can NAC hurt your gut health? Short Answer: N-acetylcysteine or NAC can be used at a dose of 600 to 2,400 milligrams per day for 5-10 days ...

How I Found My Health “Super Unlock” After 20 Years of Research and 20,000 Genes Tested

08 Oct 2023

Contributed by Lukas

Each person has one to six highly unique unlocks that will only work for them, and this is how to find them. This podcast is only available here for t...

How can I protect against oxalates? | Masterjohn Q&A Files #324

25 Sep 2023

Contributed by Lukas

Question: How can I protect against oxalates? Short Answer: Getting 300-400 mg calcium between food and supplements at each meal will minimize oxalat...

Why Should Postprandial Glucose Be Kept Under 140 mg/dL? | Masterjohn Q&A Files #323

11 Sep 2023

Contributed by Lukas

Question: Why should postprandial blood glucose be kept under 140 milligrams per deciliter? Short Answer: When blood glucose rises above 140 mg/dL, t...

Methylene Blue in 10 Minutes

02 Sep 2023

Contributed by Lukas

Watch the full-length video here: https://www.youtube.com/watch?v=XhgGGbdw4zE&t=8621s  Get my free 51--page report, Methylene Blue: Biohacker's Delig...

Methylene Blue: Biohacker's Delight, or Playing With Fire?

01 Sep 2023

Contributed by Lukas

Get the written and referenced version here: https://chrismasterjohnphd.substack.com/p/the-guide-to-methylene-blue This is a 51-page guide in which y...

What is the relationship between copper and estrogen? | Masterjohn Q&A Files #322

28 Aug 2023

Contributed by Lukas

Question: What is the relationship between copper and estrogen? Short Answer: Estrogen moves copper from the mother’s bloodstream to the fetus durin...

Why Would Citrate or Malate Cause Insomnia?

23 Aug 2023

Contributed by Lukas

This is now subscribers-only and is available here: https://chrismasterjohnphd.substack.com/p/why-would-citrate-or-malate-cause

What to Do About Constipation

22 Aug 2023

Contributed by Lukas

This is now subscribers-only and can be accessed here: https://chrismasterjohnphd.substack.com/p/what-to-do-about-constipation

How to slow or reverse graying of hair? | Masterjohn Q&A Files #321

14 Aug 2023

Contributed by Lukas

Question: How to slow graying of hairs and potentially reverse it? Short Answer: What works for any given individual will likely be to find the weakes...

How Much Iron Can We Absorb At Once? | Masterjohn Q&A Files #320

31 Jul 2023

Contributed by Lukas

Question: How much iron can we absorb at once? Short Answer: High-dose iron will produce more total absorbed iron, but will also leave more in the gut...

What cofactors are needed to synthesize and recycle BH4? | Masterjohn Q&A Files #319

17 Jul 2023

Contributed by Lukas

Question: What cofactors are needed to synthesize and recycle BH4? Short Answer: Zinc, magnesium, potassium, and niacin are the cofactors needed for ...

Is It Important to Get Vitamin D Sulfate Specifically From the Sun? | Masterjohn Q&A Files #318

03 Jul 2023

Contributed by Lukas

Question: Is it important to get vitamin D sulfate specifically from the sun? Short Answer: It is important to get morning outdoor sunlight as close ...

When to Consider Inborn Errors of Metabolism

24 Jun 2023

Contributed by Lukas

These are considered rare, yet this reinforces the pattern of never looking for them, leading them to likely be massively under-diagnosed. Many are hi...

How to Recover From Fish Oil

23 Jun 2023

Contributed by Lukas

Iris from Denmark has generously donated an hour of her consulting time with me to you, the community, so that her case can be used to raise awareness...

Can B12 and Folate Help Detoxify Oxalate?

23 Jun 2023

Contributed by Lukas

This may explain why high-dose biotin causes "oxalate dumping" symptoms in some people but not others. Written and referenced version: https://chris...

If I have a hereditary weakness in breaking down branched-chain amino acids, what cofactors do I need to consider, and do I need to restrict my protein when losing weight? | Masterjohn Q&A Files #317

19 Jun 2023

Contributed by Lukas

Question: If a person has a hereditary weakness for Branched Chain Amino Acid Catabolism would this impact the type of diet they might choose to loose...

How do I consume omega-3 without hurting my omega-6 status? | Masterjohn Q&A Files #316

05 Jun 2023

Contributed by Lukas

Question: If I don’t want to hurt my omega 6 status through my omega 3 intake, how do I do that? Is it simply a question of taking them at separate ...

Energy Metabolism Governs Everything

31 May 2023

Contributed by Lukas

That was not an exaggeration. Everything. In this podcast I cover why riboflavin abolished my allergies, why a respiratory chain disorder could cause...

Can plant foods and their phytochemicals be used to reduce arterial plaque? | Masterjohn Q&A Files #315

22 May 2023

Contributed by Lukas

Question: Can plant foods and their phytochemicals be used to reduce arterial plaque? Short Answer: Yes, but if you don’t have specific intolerances...

What to Do About Twitching | Masterjohn Q&A Files #314

08 May 2023

Contributed by Lukas

Question: What can be done about twitching? Short Answer: Most twitching will be driven by glutamate/GABA balance or acetylcholine regulation, and t...

Can Biotin Help Detoxify Oxalate?

19 Apr 2023

Contributed by Lukas

This is a hypothesis that may reconcile some anecdotes and has many hints suggested in the enzymological literature. First, make sure you get my MTHFR...

Vitamin K2 and Undercarboxylated Osteocalcin | Masterjohn Q&A Files #313

17 Apr 2023

Contributed by Lukas

Question: If undercarboxylated osteocalcin has health benefits, and vitamin K2 decreases it, what does that mean for K2 supplementation? Short Answe...

Self Experiments In the Biochemically Unoptimized State

12 Apr 2023

Contributed by Lukas

Finally, the long-awaited results of my self-experiments conducted from September through January are released! First, make sure you get my MTHFR Prot...

My MTHFR Protocol

12 Apr 2023

Contributed by Lukas

I have a free gift for you. That is my MTHFR Protocol, a 7-page quick guide to optimizing and personalizing your methylation status using foods and su...

Getting to the Bottom of My Health: Biotin and (V)LCAD

06 Apr 2023

Contributed by Lukas

For nearly 20 years, I have strongly suspected that I have a genetic disorder in synthesizing or recycling something that is absent or poorly availabl...

Phosphatidylcholine and TMAO | Masterjohn Q&A Files #312

03 Apr 2023

Contributed by Lukas

Question: If I'm at risk of heart disease and phosphatidylcholine increases my TMAO, should I stop the supplement? Short Answer: On a scale of one t...

Raising Ceruloplasmin When Copper Won't Do It | Masterjohn Q&A Files #312

03 Apr 2023

Contributed by Lukas

Question: How do I get my ceruloplasmin up if copper doesn't raise it? Short Answer: Usually ceruloplasmin raises with copper, which may be important...

Does Erythritol Cause Heart Disease?

24 Mar 2023

Contributed by Lukas

This analysis of the recent study by the Hazen group at Cleveland Clinic published in Nature Medicine claiming erythritol contributes to cardiovascula...

Low Blood Sugar on Vegan Keto | Masterjohn Q&A Files #311

20 Mar 2023

Contributed by Lukas

Question: How do I fix low blood sugar on vegan keto? Short Answer: Consider how important it is for your ketones to be elevated. Most likely you nee...

Brain Fog on Calcium, Vitamin D, or K2 | Masterjohn Q&A Files #310

06 Mar 2023

Contributed by Lukas

Question: Why would vitamin D, vitamin K2, and calcium give me brain fog? Short Answer: Most likely by decreasing serum phosphorus. The solution is ...

Why Plasma Zinc is the Best Marker of Zinc Status | Masterjohn Q&A Files #309

20 Feb 2023

Contributed by Lukas

Short Answer: Plasma zinc is the single most important marker of zinc status. Urine zinc may decline faster in deficiency. Hair zinc increases with su...

Glutathione Intolerance: Getting to the Bottom of It | Masterjohn Q&A Files #308

06 Feb 2023

Contributed by Lukas

Short Answer: It could be byproducts of any of the three amino acids that make up the glutathione molecule, which include the individual amino acids, ...

Statins Vs. Sulfur for Heart Disease | Masterjohn Q&A Files #307

23 Jan 2023

Contributed by Lukas

Short Answer: From the trials, statins seem to reduce heart disease risk and total mortality, but it is impossible to separate this from conflicts of ...

Why would someone not tolerate methyl donors even if they need them? | Masterjohn Q&A Files #306

09 Jan 2023

Contributed by Lukas

Short Answer: I believe most methyl donor intolerances are a result of deficiencies in the glycine buffer system, which requires glycine, vitamin A, f...

Does whey protein hurt the kidneys or otherwise hurt our health? | Masterjohn Q&A Files #305

26 Dec 2022

Contributed by Lukas

Short Answer: The main problem with too much protein, particularly animal protein, is that acidity may hurt the bones and increase the risk of calciu...

Biotin Causes a Multitude of False Lab Tests | Here is What to Do

20 Dec 2022

Contributed by Lukas

High-dose biotin supplements can cause a multitude of false lab tests, masking recent heart attacks, pregnancies, or allergies, giving false signals a...

Does glucose handling in the brain decline with age? And if so, does this serve as a rationale to supplement with MCT oil to prevent cognitive decline? | Masterjohn Q&A Files #304

12 Dec 2022

Contributed by Lukas

Short Answer: Energy metabolism in general declines across the body with aging, but energy metabolism seems to stay healthy enough in the brain in peo...

Why is an IV more hydrating than salted water? | Masterjohn Q&A Files #303

28 Nov 2022

Contributed by Lukas

Short Answer: If it can’t be explained by the dose of salt, it may be that the salt is not being absorbed orally. Glucose, starch, or simply a meal...

Thyroid Toxins: TODAY ONLY

25 Nov 2022

Contributed by Lukas

The audio and written form of this report are available to everyone for free TODAY ONLY. Listen in while it's available! Here it is in written form, w...

Nutrition and Immunity -- TODAY ONLY

23 Nov 2022

Contributed by Lukas

This 2-hour lesson on Nutrition and Immunity is ordinarily reserved for Masterpass members but it is free today only. Listen in while you have access!...

Nutrition and Immunity -- TODAY ONLY

23 Nov 2022

Contributed by Lukas

This 2-hour lesson on Nutrition and Immunity is ordinarily reserved for Masterpass members, but today only, it's yours for free. Listen in while it's ...

Staying Immune Through the Winter

23 Nov 2022

Contributed by Lukas

Get my new 7-page quick guide on how to not get sick for free when you sign up to my Substack: https://chrismasterjohnphd.substack.com/p/staying-immu...

How to Increase or Decrease SHBG? | Masterjohn Q&A Files #302

14 Nov 2022

Contributed by Lukas

Short Answer: SHBG is increased by adiponectin (vitamin K2, insulin sensitivity), thyroid hormone, fasting physiology (AMPK, fat oxidation), and estro...

COVID Vaccine Side Effects: What Causes Them?

05 Nov 2022

Contributed by Lukas

I am done with my work on COVID vaccines, at least until I finish my Vitamins and Minerals 101 Book, so I am now making my scientific review on the l...

Protein and Longevity | Masterjohn Q&A Files #301

24 Oct 2022

Contributed by Lukas

Short Answer: While protein restriction may have value in people with established cancer or kidney disease, cycling robustly between fasting and feed...

Why do my urinary B6 markers say I'm deficient if I'm supplementing and my plasma levels are high-normal? | Masterjohn Q&A Files #300

10 Oct 2022

Contributed by Lukas

Short answer: Low or low-normal alkaline phosphatase may raise the plasma B6 level over the cellular level. Tryptophan metabolites in urine reflect th...

The 3 Phases of Fasting: And How to Get Kicked Out of Each One | Masterjohn Q&A Files #299

26 Sep 2022

Contributed by Lukas

Short answer: 4-6 hours after a meal the small intestine is emptied and the insulin-to-glucagon ratio declines; 25 hours after, hepatic glycogen is em...

Will reishi, turmeric, or curcumin tank my testosterone? | Masterjohn Q&A Files #298

12 Sep 2022

Contributed by Lukas

Short answer: Probably not. Animal studies showing a difference use huge doses in an unrealistic context. Human studies show they don’t at doses use...

What if my A1C says I'm diabetic but my CGM says I'm fine? | Masterjohn Q&A Files #297

22 Aug 2022

Contributed by Lukas

Short answer: Trust the CGM. HbA1c is confounded by red blood cell turnover and fructosamine 3-kinase activity. This is a clip from a live Q&A ses...

Chips! The Only Ones I'll Endorse

21 Jul 2022

Contributed by Lukas

My friend Steve, who is the one who originally introduced me to the Essex Farm CSA that now supplies me with almost all my food, has invented a new to...

The Ancestral Health Debate

23 Jun 2022

Contributed by Lukas

Nick Hiebert and I debate the value of ancestral health as a framework for approaching health in the modern era. For my summary of and reflections on ...

Mathew Crawford: Fraud in the Military's Health Database?

22 Jun 2022

Contributed by Lukas

In this interview, Mathew Crawford walks me through his slide presentation of data showing that, at some point between 2020 and 2021, the 2016-2019 da...

Nutrition in Neuroscience Part 2 | Mastering Nutrition #41

09 Jun 2022

Contributed by Lukas

Part 2 of how NUTRITION has a HUGE impact on your BRAIN! Everything in your brain is something you ate, something you made from something you ate, o...

A New Paradigm for Severe COVID

25 May 2022

Contributed by Lukas

This new model I developed explains how the depletion of arginine and tryptophan and the sequestration of cysteine leads to T cell suppression in seve...

Reversing Fatty Liver: How Long Does It Take? | Masterjohn Q&A Files #296

30 Apr 2022

Contributed by Lukas

Short answer: You should be able to see changes on imaging within a few weeks if your approach is working well, but ultimately this is entirely depend...

What's the difference between 25(OH)D and 1,25(OH)2D when it comes to the VDR? | Masterjohn Q&A Files #295

29 Apr 2022

Contributed by Lukas

Short answer: 25(OH)D is 1000 times weaker at activating the VDR than 1,25(OH)D, but 1000 times more abundant. This is why I advocate measuring both, ...

Can Regenerative Agriculture Solve the Food Crisis?

18 Apr 2022

Contributed by Lukas

Rising Food Prices Part 4: Can Regenerative Agriculture Solve the Food Crisis? This is the 4th in a series of interviews I am conducting to try to be...

Rising Food Prices Part 3: The Commodity Trade

08 Apr 2022

Contributed by Lukas

Tony Greer joins me to talk about how lockdowns, politics, and the commodity trade contribute to rising food prices. Tony Greer is partly responsible ...

Rising Food Prices Part 2: "Money Printing"

06 Apr 2022

Contributed by Lukas

With Dr. Michael Howell, PhD. This is the second in a series of interviews I am conducting to try to better understand why food prices have been risin...

Rising Food Prices Part 1: Oil and Fertilizer

02 Apr 2022

Contributed by Lukas

This is the first in a series of interviews I am conducting to try to better understand why food prices have been rising, where they are going as we m...

The Spike Protein As a Pore-Forming Toxin

30 Mar 2022

Contributed by Lukas

The spike protein pokes holes in cell membranes at concentrations much lower than those achieved with vaccination, contributing to COVID-like illness ...

The Emerging Food Crisis

29 Mar 2022

Contributed by Lukas

My tentative view on what is causing it and what to do about it. This is NOT caused primarily by the conflict in Ukraine and a sudden peaceful solutio...

Explaining the "Hospitalization Paradox"

04 Mar 2022

Contributed by Lukas

https://chrismasterjohnphd.com/paradox  Please subscribe to my Substack at https://chrismasterjohnphd.substack.com Subscription is completely free bu...

I'm About to Get Deplatformed

30 Jan 2022

Contributed by Lukas

I'm recording from "Youtube Jail," where I'll be until Monday morning. Two more strikes and I'm out. Please help our community stay connected by joini...

The Hospitals Are Not Full of COVID Patients

29 Jan 2022

Contributed by Lukas

The pandemic that no one dare speak of: 79% of people hospitalized for COVID-like illness test negative for COVID. The vaccines protect against testi...

Strategizing Against Vaccine Mandates with Angela McArdle

14 Jan 2022

Contributed by Lukas

In this episode, Chris Masterjohn interviews Angela McArdle on strategies to defeat the mandates. McArdle is the current chair of the Los Angeles Libe...

Angela McArdle

11 Jan 2022

Contributed by Lukas

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Dmitry Kats, PhD: From Niatonin to Niacur

04 Jan 2022

Contributed by Lukas

In this episode, I have Dr. Dmitry Kats, MPH, PhD. He has a PhD in epidemiology from the University of North Carolina at Chapel Hill. Many people have...

Jessica Rose: Adverse Events Reporting and Much More

27 Dec 2021

Contributed by Lukas

In this episode, I have a fascinating 3-hour conversation with Dr. Jessica Rose about all things related to C-word juices, ranging from interpreting t...

Patenting the Human Genome With Law Professor Jorge L. Contreras

20 Dec 2021

Contributed by Lukas

In this episode, I interview Law Professor Jorge Contreras about the past, present, and future of biotech companies patenting the human genome. Jorge ...

Tess Lawrie

12 Dec 2021

Contributed by Lukas

In this episode, I interview Tess Lawrie about Iver Mixin', public health corruption, and C-word juices. Tess is a medical doctor with expertise in re...