121: LSD: Subjectivity, Ineffability, and Mental Health feat. Dan Karlin

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Recorded08 Nov 2025

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Handlerec:6550027

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Abby and Patrick continue their series on psychedelics via an in-depth interview with Dr. Dan Karlin. Karlin is a psychiatrist and Chief Medical Officer at MindMed, where he oversees clinical trials using LSD to treat major depressive disorder (MDD) and generalized anxiety disorder (GAD). Karlin first fills Abby and Patrick in about those disorders, MindMed’s ongoing clinical trials, and both the history of LSD research and potential near-future therapeutic applications. In the wide-ranging conversation that follows, they explore provocative questions about the relationship between quantitative research and qualitative description, the challenges of thinking simultaneously about neurobiology and phenomenology, and how various models fall short in different ways when it comes to describing ineffable experiences. They also probe what Karlin’s work suggests about the ways bodily perceptions, metaphors, and narrative shape our subjective sense of self, how the symptoms of MDD and GAD can be seen in that light, and how certain psychedelics may work to rapidly reorganize those underlying patterns and configurations in ways that mirror the work of long-term therapy.Note: All opinions are Karlin's own and not attributable to MindMedHave you noticed that Freud is back? Got questions about psychoanalysis? Or maybe you’ve traversed the fantasy and lived to tell the tale? Leave us a voicemail! (646) 450-0847 A podcast about psychoanalysis, politics, pop culture, and the ways we suffer now. New episodes on Saturdays. Follow us on social media: Linktree: https://linktr.ee/OrdinaryUnhappiness Twitter: @UnhappinessPod Instagram: @OrdinaryUnhappiness Patreon: patreon.com/OrdinaryUnhappiness Theme song: Formal Chicken - Gnossienne No. 1 https://open.spotify.com/album/2MIIYnbyLqriV3vrpUTxxO Provided by Fruits Music

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