Perimenopause is already handing out enough surprises without the internet yelling that menopausal hormone therapy is either a miracle cardiology cape or a one-way ticket to doom. In this episode of OvaryActive, Dr. Rebecca Dunsmoor-Su and Dr. Amy Voedisch take on the very confusing question of whether hormone therapy can help prevent cardiovascular disease in menopause. They walk through the history of hormone therapy and heart health, from large observational studies like Framingham and the Nurses' Health Study to the much-debated Women's Health Initiative, a study that launched roughly a thousand menopause panic spirals. The doctors explain why timing matters, why older hormone therapy data does not always apply to today's estradiol options, and why oral versus transdermal estrogen is more nuanced than "patch good, pill bad." So yes, hormones can be fabulous. But no, they do not replace exercise, lipid screening, diabetes care, statins when needed, or the deeply annoying truth that lifestyle still matters. What you'll hear in this episode: [2:45] Where the "estrogen protects the heart" idea came from [5:02] The Women's Health Initiative and why timing matters [6:31] Plaque, blood clots, and starting hormones later [7:26] The timing hypothesis and "window of opportunity" [7:59 Older hormone therapy studies don't always match current treatments…why? [12:04] What we know about oral estradiol, transdermal estrogen, and the liver [16:40] Medicare data, mortality claims, and why database studies are tricky [18:37] Can MHT prevent cardiovascular disease? [20:37] Proven heart-health strategies that matter most [22:42] What hormones can help with, and what they CAN'T promise Follow the show @OvaryActive Instagram | YouTube | perimenopausedrs.com/ovaryactive Estrogen, Interrupted by Dr. Rebecca Dunsmoor-Su & Dr. Amy Voedisch Meet the Docs: More information about Dr. Rebecca Dunsmoor-Su: Gennev: www.gennev.com/clinician/dr-rebecca-dunsmoor-su LinkedIn @rebecca-dunsmoor-su More information about Dr. Amy Voedisch: Stanford Medical Clinic: stanfordhealthcare.org/doctors/v/amy-voedisch.html This episode was produced by Audiotocracy Podcast Production.

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