Fact Check My Feed: What’s Up With These COVID-19 Mutations? It’s a new year, and that means there’s a whole slew of new COVID-19 news to dive into, including an overwhelming amount of new information about vaccines and mutations. The U.S. has now administered roughly five million doses of COVID-19 vaccines, far behind the nation’s goal of vaccinating 20 million by the end of 2020. The two approved COVID-19 vaccines, one from Pfizer and one from Moderna, are intended to be given over the course of two doses. But there’s a discussion within the medical community about whether or not both doses are necessary for every patient. Mutations are also an increasing concern. Variants from the U.K. and South Africa are concerning epidemiologists, and appear to be spreading. Though there’s no proof that either are more deadly, they may be more infectious. Joining Ira to explain is Angela Rasmussen, a virologist at Georgetown University’s Center for Global Health Science and Security, based in Seattle, Washington. Can Cells Rewind The Wrinkles Of Time? As a cell ages, its DNA goes through a process called “methylation”—gaining extra methyl chemical groups. These groups can affect how the genes’ encoded information is expressed, without actually changing the sequence of genes. In work published in Nature, researchers explore whether reversing that methylation can reprogram the cells back to a more youthful state. They used modified adenoviruses to introduce three specific transcription factors into mouse retinal ganglion cells, a type of neuron found in the eye. These transcription factors helped revert the cell to a more immature state—and also seemed to let the cell behave in a more ‘youthful’ way. David Sinclair, a professor of genetics at Harvard Medical School and one of the authors of the study, joins Ira to discuss what the work means, and what it could tell scientists about the aging process. Trump’s New EPA ‘Transparency’ Rule Could Hamper Science This week, the Environmental Protection Agency passed the “Strengthening Transparency in Regulatory Science” rule. EPA Administrator Andrew Wheeler stated that “the American public has the right to know what scientific studies underline the Agency’s regulatory decisions.” But critics say that this outgoing policy by the Trump administration can be used to hamper new environmental regulations. Amy Nordrum lines out the policy and other science headlines from the week. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

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