Science Magazine Podcast

Fixing fat bubbles for vaccines, and preventing pain from turning chronic

12 May 2022

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On this week’s show: Lipid nanoparticles served us well as tiny taxis delivering millions of mRNA vaccines against COVID-19, but they aren’t optimized—yet, and why we might need inflammation to stop chronic pain The messenger RNA payload of the mRNA vaccines against SARS-CoV-2 is wrapped up in little fatty packets called lipid nanoparticles (LNPs). These fat bubbles were originally designed for something much different—carrying molecules into cells to silence genes. But they were useful and we were in a hurry, so not much was changed about them when they were pressed into service against COVID-19. Science journalist Elie Dolgin talks with host Sarah Crespi about ongoing efforts to improve LNPs as a delivery system for mRNA vaccines and therapeutic treatments. Next on the show, we hear about “pain chronification.” Have you ever thought about chronic pain? What happens in the body when it heals—no specific thing is broken—but the pain never subsides? Sarah chats with Luda Diatchenko, professor on the faculties of medicine and dentistry at McGill University, about her Science Translational Medicine paper on the need for inflammation to prevent pain chronification. This week’s episode was produced with help from Podigy. [Image: V. Altounian/Science; Music: Jeffrey Cook] [alt: lipid nanoparticle illustration with podcast symbol overlay] Authors: Sarah Crespi; Elie Dolgin Episode page: https://www.science.org/doi/10.1126/science.adc9455 About the Science Podcast: https://www.science.org/content/page/about-science-podcast Learn more about your ad choices. Visit megaphone.fm/adchoices

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13:00H | 21 DIC 2025 | Fin de Semana

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12:00H | 20 DIC 2025 | Fin de Semana

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2ª PARTE | 06 ENE 2026 | EL PARTIDAZO DE COPE

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El Partidazo de COPE

3ª PARTE | 22 ENE 2026 | EL PARTIDAZO DE COPE

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El Partidazo de COPE

3ª PARTE | 04 MAR 2026 | EL PARTIDAZO DE COPE

01 Jan 1970

El Partidazo de COPE

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Science Magazine Podcast

Fixing fat bubbles for vaccines, and preventing pain from turning chronic

This episode hasn't been transcribed yet

Other recent transcribed episodes

13:00H | 21 DIC 2025 | Fin de Semana

10:00H | 21 DIC 2025 | Fin de Semana

12:00H | 20 DIC 2025 | Fin de Semana

2ª PARTE | 06 ENE 2026 | EL PARTIDAZO DE COPE

3ª PARTE | 22 ENE 2026 | EL PARTIDAZO DE COPE

3ª PARTE | 04 MAR 2026 | EL PARTIDAZO DE COPE

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